SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 12 HIS A   8
GLU A  36
LEU A  15
LEU A  28
GLY A  29
 None
 1.09A 1xwfA-4l8lA:
5.1		 1xwfA-4l8lA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 12 HIS A   8
GLU A  36
LEU A  15
LEU A  28
GLY A  29
 None
 1.08A 1xwfB-4l8lA:
5.0		 1xwfB-4l8lA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 12 HIS A   8
GLU A  36
LEU A  15
LEU A  28
GLY A  29
 None
 1.09A 1xwfC-4l8lA:
4.3		 1xwfC-4l8lA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 12 HIS A   8
GLU A  36
LEU A  15
LEU A  28
GLY A  29
 None
 1.08A 1xwfD-4l8lA:
4.2		 1xwfD-4l8lA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  12
LEU A 102
VAL A 100
ILE A  31
THR A  80
 None
 1.13A 3frbX-4l8lA:
2.3		 3frbX-4l8lA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  12
LEU A 102
VAL A 100
ILE A  31
THR A  80
 None
 1.17A 3freX-4l8lA:
undetectable		 3freX-4l8lA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  77
ASN A  75
PRO A  76
TYR A 133
LEU A  12
 None
 1.36A 4xqeA-4l8lA:
4.9		 4xqeA-4l8lA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  77
ASN A  75
PRO A  76
TYR A 133
LEU A  12
 None
 1.36A 4xqeB-4l8lA:
4.8		 4xqeB-4l8lA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  77
ASN A  75
PRO A  76
TYR A 133
LEU A  12
 None
 1.37A 4xrgB-4l8lA:
4.9		 4xrgB-4l8lA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4l8l 3-DEHYDROQUINATE
DEHYDRATASE 1
(Pseudomonas
aeruginosa) 		5 / 10 PHE A  71
ILE A  73
ASN A  32
LEU A  28
LEU A   7
 None
 1.43A 6r2eC-4l8lA:
undetectable		 6r2eC-4l8lA:
22.70