SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		3 / 3 ASP A 157
PHE A 161
VAL A 154
 None
 0.73A 1kijB-4l8nA:
undetectable		 1kijB-4l8nA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		3 / 3 HIS A 300
ASP A 294
ASN A 176
 None
 0.86A 1wg8B-4l8nA:
undetectable		 1wg8B-4l8nA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		3 / 3 LYS A 324
ASP A 343
ASP A 127
 None
 0.87A 2br4D-4l8nA:
undetectable		 2br4D-4l8nA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		3 / 3 SER A  38
THR A 152
GLN A 307
 None
 0.69A 2fk8A-4l8nA:
undetectable		 2fk8A-4l8nA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		4 / 7 TYR A 432
GLY A 330
THR A 329
ASP A 345
 None
 0.95A 2g70A-4l8nA:
undetectable		 2g70A-4l8nA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		4 / 7 TYR A 432
GLY A 330
THR A 329
ASP A 345
 None
 0.90A 2g70B-4l8nA:
undetectable		 2g70B-4l8nA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		4 / 7 VAL A 301
PHE A 167
THR A 192
PHE A 169
 None
 1.01A 4ejjB-4l8nA:
undetectable		 4ejjB-4l8nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		4 / 6 GLU A 180
ILE A 183
ASN A 184
VAL A 277
 None
 1.06A 4ejwB-4l8nA:
undetectable		 4ejwB-4l8nA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		4 / 5 PHE A 450
TYR A 432
THR A 466
ILE A 463
 None
 1.11A 4jx1E-4l8nA:
undetectable		 4jx1E-4l8nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		4 / 8 SER A 423
SER A 431
GLU A 139
TYR A 390
 None
 1.00A 4qb9D-4l8nA:
undetectable		 4qb9D-4l8nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		5 / 10 ILE A 355
ILE A 331
VAL A 461
TYR A 432
ILE A 364
 None
 1.39A 5mzrA-4l8nA:
undetectable		 5mzrA-4l8nA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4l8n PDZ DOMAIN PROTEIN
(Parabacteroides
distasonis) 		5 / 9 ILE A 355
ILE A 331
VAL A 461
TYR A 432
ILE A 364
 None
 1.38A 5mzrD-4l8nA:
undetectable		 5mzrD-4l8nA:
10.11