SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4l8o BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hylemonae) 		4 / 5 ILE A  50
LEU A  46
ASP A 129
GLU A 132
 None
 0.88A 4nkxB-4l8oA:
undetectable		 4nkxB-4l8oA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4l8o BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hylemonae) 		3 / 3 ASP A  35
LEU A  34
PHE A  31
 None
 0.61A 4pthA-4l8oA:
undetectable		 4pthA-4l8oA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4l8o BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hylemonae) 		3 / 3 LEU A 108
PHE A 153
ILE A 109
 None
 0.68A 5dzk1-4l8oA:
undetectable
5dzkF-4l8oA:
undetectable
5dzkM-4l8oA:
undetectable		 5dzk1-4l8oA:
3.08
5dzkF-4l8oA:
20.76
5dzkM-4l8oA:
21.10