SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4l8p BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hiranonis) 		5 / 12 LEU A  26
ILE A 139
LEU A  42
LEU A  34
PHE A  31
 None
1PE  A 204 ( 4.6A)
None
None
None
 1.03A 2bdmA-4l8pA:
undetectable		 2bdmA-4l8pA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 4l8p BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hiranonis) 		3 / 3 ASN A 107
LEU A 108
HIS A  83
 None
None
1PE  A 204 ( 4.6A)
 0.84A 2q6fB-4l8pA:
undetectable		 2q6fB-4l8pA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4l8p BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hiranonis) 		3 / 3 THR A  87
LYS A  58
GLU A  89
 None
 0.84A 3ijdB-4l8pA:
undetectable		 3ijdB-4l8pA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4l8p BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hiranonis) 		3 / 3 ASP A  35
LEU A  34
PHE A  31
 None
 0.61A 4pthA-4l8pA:
undetectable		 4pthA-4l8pA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4l8p BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hiranonis) 		3 / 3 LEU A 108
PHE A 152
ILE A 109
 None
 0.67A 5dzk1-4l8pA:
undetectable
5dzkF-4l8pA:
undetectable
5dzkM-4l8pA:
undetectable		 5dzk1-4l8pA:
3.08
5dzkF-4l8pA:
22.51
5dzkM-4l8pA:
20.09