SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4l8t UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 10 VAL A1691
TRP A1639
LEU A1670
LEU A1640
ALA A1651
 None
 1.06A 1pbcA-4l8tA:
undetectable		 1pbcA-4l8tA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4l8t UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 9 VAL A1691
TRP A1639
LEU A1670
LEU A1640
ALA A1651
 None
 1.08A 1pbfA-4l8tA:
undetectable		 1pbfA-4l8tA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4l8t UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		3 / 3 LEU A1631
LEU A1588
MET A1516
 None
 0.71A 1ya3B-4l8tA:
undetectable		 1ya3B-4l8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4l8t UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		3 / 3 SER A1599
ASP A1677
ASP A1596
 None
 0.74A 3iv6A-4l8tA:
undetectable		 3iv6A-4l8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4l8t UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		3 / 3 SER A1599
ASP A1677
ASP A1596
 None
 0.71A 3iv6C-4l8tA:
undetectable		 3iv6C-4l8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4l8t UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 7 PHE A1443
SER A1733
ILE A1730
LEU A1378
 None
 0.60A 4uymA-4l8tA:
undetectable		 4uymA-4l8tA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4l8t UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		5 / 11 PHE A1443
VAL A1389
ILE A1392
ILE A1379
ILE A1427
 None
 1.09A 5hw8A-4l8tA:
undetectable
5hw8D-4l8tA:
undetectable		 5hw8A-4l8tA:
14.25
5hw8D-4l8tA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4l8t UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 6 ILE A1392
ILE A1379
LEU A1382
PHE A1734
 None
 1.02A 5vkqA-4l8tA:
undetectable
5vkqB-4l8tA:
undetectable		 5vkqA-4l8tA:
14.70
5vkqB-4l8tA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4l8t UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens) 		4 / 6 ILE A1392
ILE A1379
LEU A1382
PHE A1734
 None
 1.00A 5vkqA-4l8tA:
undetectable
5vkqD-4l8tA:
undetectable		 5vkqA-4l8tA:
14.70
5vkqD-4l8tA:
14.70