SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l95'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 6 THR E 204
ASN E 194
LEU E 134
TRP E 217
 None
 1.26A 1mxdA-4l95E:
undetectable		 1mxdA-4l95E:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 12 MET E 205
LEU E 124
ILE E 173
VAL E 202
LEU E 116
 None
 0.92A 1wsvA-4l95E:
undetectable		 1wsvA-4l95E:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 12 MET E 205
LEU E 124
ILE E 173
VAL E 202
LEU E 116
 None
 0.92A 1wsvB-4l95E:
undetectable		 1wsvB-4l95E:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.12A 1zzrA-4l95E:
undetectable
1zzrB-4l95E:
undetectable		 1zzrA-4l95E:
19.10
1zzrB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.09A 1zzrA-4l95E:
undetectable
1zzrB-4l95E:
undetectable		 1zzrA-4l95E:
19.10
1zzrB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.11A 1zzuA-4l95E:
undetectable
1zzuB-4l95E:
undetectable		 1zzuA-4l95E:
19.10
1zzuB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.10A 1zzuA-4l95E:
undetectable
1zzuB-4l95E:
undetectable		 1zzuA-4l95E:
19.10
1zzuB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 6 LEU E  93
ASN E 181
ILE E 212
PHE E 210
 None
 1.19A 2jn3A-4l95E:
undetectable		 2jn3A-4l95E:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.11A 3dqrA-4l95E:
undetectable
3dqrB-4l95E:
undetectable		 3dqrA-4l95E:
19.10
3dqrB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.08A 3dqrA-4l95E:
undetectable
3dqrB-4l95E:
undetectable		 3dqrA-4l95E:
19.10
3dqrB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		3 / 3 TYR E  34
TYR E  29
GLY E  71
 None
 0.74A 3eteB-4l95E:
undetectable
3eteD-4l95E:
2.1
3eteF-4l95E:
2.1		 3eteB-4l95E:
22.22
3eteD-4l95E:
22.22
3eteF-4l95E:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.10A 3jx2A-4l95E:
undetectable
3jx2B-4l95E:
undetectable		 3jx2A-4l95E:
19.10
3jx2B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.11A 3jx2A-4l95E:
undetectable
3jx2B-4l95E:
undetectable		 3jx2A-4l95E:
19.10
3jx2B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.12A 3jx3A-4l95E:
undetectable
3jx3B-4l95E:
undetectable		 3jx3A-4l95E:
19.10
3jx3B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.12A 3jx3A-4l95E:
undetectable
3jx3B-4l95E:
undetectable		 3jx3A-4l95E:
19.10
3jx3B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.09A 3jx4A-4l95E:
undetectable
3jx4B-4l95E:
undetectable		 3jx4A-4l95E:
19.10
3jx4B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.08A 3jx5A-4l95E:
undetectable
3jx5B-4l95E:
undetectable		 3jx5A-4l95E:
19.10
3jx5B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.09A 3jx5A-4l95E:
undetectable
3jx5B-4l95E:
undetectable		 3jx5A-4l95E:
19.10
3jx5B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.07A 3jx6A-4l95E:
undetectable
3jx6B-4l95E:
undetectable		 3jx6A-4l95E:
19.10
3jx6B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.10A 3jx6A-4l95E:
undetectable
3jx6B-4l95E:
undetectable		 3jx6A-4l95E:
19.10
3jx6B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 6 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.09A 3n61A-4l95E:
undetectable
3n61B-4l95E:
undetectable		 3n61A-4l95E:
19.10
3n61B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.10A 3n61A-4l95E:
undetectable
3n61B-4l95E:
undetectable		 3n61A-4l95E:
19.10
3n61B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.07A 3nljA-4l95E:
undetectable
3nljB-4l95E:
0.0		 3nljA-4l95E:
19.10
3nljB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.07A 3nljA-4l95E:
undetectable
3nljB-4l95E:
0.0		 3nljA-4l95E:
19.10
3nljB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.10A 3nlpA-4l95E:
undetectable
3nlpB-4l95E:
undetectable		 3nlpA-4l95E:
19.10
3nlpB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.11A 3nlpA-4l95E:
undetectable
3nlpB-4l95E:
undetectable		 3nlpA-4l95E:
19.10
3nlpB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 8 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.09A 3nlqA-4l95E:
undetectable
3nlqB-4l95E:
undetectable		 3nlqA-4l95E:
19.10
3nlqB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.11A 3nlqA-4l95E:
undetectable
3nlqB-4l95E:
undetectable		 3nlqA-4l95E:
19.10
3nlqB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.10A 3nlrA-4l95E:
undetectable
3nlrB-4l95E:
undetectable		 3nlrA-4l95E:
19.10
3nlrB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 8 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.11A 3nlrA-4l95E:
undetectable
3nlrB-4l95E:
undetectable		 3nlrA-4l95E:
19.10
3nlrB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 11 PRO E 211
ILE E 212
TYR E 101
TYR E 213
GLU E 251
 None
 1.22A 3q5rA-4l95E:
undetectable		 3q5rA-4l95E:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.11A 4cx3A-4l95E:
undetectable
4cx3B-4l95E:
undetectable		 4cx3A-4l95E:
19.10
4cx3B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.13A 4cx3A-4l95E:
undetectable
4cx3B-4l95E:
undetectable		 4cx3A-4l95E:
19.10
4cx3B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.11A 4cx4A-4l95E:
undetectable
4cx4B-4l95E:
undetectable		 4cx4A-4l95E:
19.10
4cx4B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.13A 4cx4A-4l95E:
undetectable
4cx4B-4l95E:
undetectable		 4cx4A-4l95E:
19.10
4cx4B-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 10 VAL E  45
ALA E  43
PHE E  37
SER E  33
VAL E  14
 None
 1.33A 4eilB-4l95E:
undetectable		 4eilB-4l95E:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 10 VAL E  45
ALA E  43
PHE E  61
LEU E  60
VAL E  46
 None
 1.45A 4eilB-4l95E:
undetectable		 4eilB-4l95E:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 ILE E 212
PRO E 211
GLY E  99
ALA E  92
 None
 0.86A 4g0uB-4l95E:
2.1		 4g0uB-4l95E:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		8 / 11 GLY E  71
GLY E  72
GLY E  73
LEU E 109
GLU E 112
HIS E 169
GLN E 170
TRP E 171
 None
 0.63A 4l8fB-4l95E:
51.9		 4l8fB-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 11 GLY E  71
GLY E  72
LEU E 109
GLU E 112
TRP E 171
 None
 1.13A 4l8fB-4l95E:
51.9		 4l8fB-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 11 GLY E  71
LEU E 109
GLU E 112
HIS E 169
TRP E 171
 None
 1.09A 4l8fB-4l95E:
51.9		 4l8fB-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 11 GLY E  72
GLY E  73
LEU E 109
GLU E 112
HIS E 169
 None
 1.00A 4l8fB-4l95E:
51.9		 4l8fB-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 11 GLY E  72
LEU E 109
GLU E 112
GLN E 170
TRP E 171
 None
 1.16A 4l8fB-4l95E:
51.9		 4l8fB-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		7 / 11 GLY E  71
GLY E  72
GLY E  73
LEU E 109
GLU E 112
HIS E 169
TRP E 171
 None
 0.38A 4l8fD-4l95E:
51.8		 4l8fD-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		7 / 11 GLY E  71
GLY E  72
LEU E 109
GLU E 112
HIS E 169
GLN E 170
TRP E 171
 None
 0.47A 4l8fD-4l95E:
51.8		 4l8fD-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 11 GLY E  71
LEU E 109
GLU E 112
HIS E 169
GLN E 170
 None
 1.13A 4l8fD-4l95E:
51.8		 4l8fD-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 11 GLY E  72
GLY E  73
LEU E 109
GLU E 112
HIS E 169
 None
 1.01A 4l8fD-4l95E:
51.8		 4l8fD-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 11 GLY E  72
LEU E 109
GLU E 112
GLN E 170
TRP E 171
 None
 1.13A 4l8fD-4l95E:
51.8		 4l8fD-4l95E:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 9 GLY E  72
LEU E 109
GLU E 112
GLN E 170
TRP E 171
 None
 1.18A 4l8wG-4l95E:
51.6		 4l8wG-4l95E:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		9 / 9 PHE E  20
GLY E  71
GLY E  73
CYH E 108
LEU E 109
GLU E 112
HIS E 169
GLN E 170
TRP E 171
 None
 0.48A 4l8wG-4l95E:
51.6		 4l8wG-4l95E:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 9 GLY E  72
LEU E 109
GLU E 112
GLN E 170
TRP E 171
 None
 1.19A 4l8wI-4l95E:
51.9		 4l8wI-4l95E:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		9 / 9 PHE E  20
GLY E  71
GLY E  73
CYH E 108
LEU E 109
GLU E 112
HIS E 169
GLN E 170
TRP E 171
 None
 0.45A 4l8wI-4l95E:
51.9		 4l8wI-4l95E:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		3 / 3 THR E 118
ASN E  96
PHE E 102
 None
 0.71A 4pd9A-4l95E:
undetectable		 4pd9A-4l95E:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.10A 5addA-4l95E:
undetectable
5addB-4l95E:
0.0		 5addA-4l95E:
19.10
5addB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.04A 5adeA-4l95E:
undetectable
5adeB-4l95E:
undetectable		 5adeA-4l95E:
19.10
5adeB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 VAL E  45
VAL E 249
PHE E  37
GLU E  39
 None
 1.09A 5g0pA-4l95E:
undetectable
5g0pB-4l95E:
undetectable		 5g0pA-4l95E:
19.10
5g0pB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 7 PHE E  37
GLU E  39
VAL E  45
VAL E 249
 None
 1.07A 5g0pA-4l95E:
undetectable
5g0pB-4l95E:
undetectable		 5g0pA-4l95E:
19.10
5g0pB-4l95E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		5 / 12 ILE E 238
THR E 227
GLU E 285
PHE E  37
ALA E 245
 None
 1.41A 5iwuA-4l95E:
undetectable		 5iwuA-4l95E:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4l95 GAMMA-GLUTAMYL
HYDROLASE
(Danio
rerio) 		4 / 5 TYR E  34
LEU E 113
GLY E 110
PHE E  69
 None
 0.96A 5kmdC-4l95E:
undetectable
5kmdD-4l95E:
undetectable		 5kmdC-4l95E:
22.26
5kmdD-4l95E:
22.26