SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4l9c F-BOX ONLY PROTEIN 7
(Homo
sapiens) 		4 / 4 LYS A 220
LEU A 208
ALA A 221
LEU A 205
 None
 1.48A 1f86B-4l9cA:
undetectable		 1f86B-4l9cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4l9c F-BOX ONLY PROTEIN 7
(Homo
sapiens) 		3 / 3 PHE A 308
TYR A 238
TYR A 212
 None
 1.00A 1x70B-4l9cA:
undetectable		 1x70B-4l9cA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4l9c F-BOX ONLY PROTEIN 7
(Homo
sapiens) 		4 / 8 THR A 217
PRO A 225
ALA A 221
PRO A 214
 None
 0.94A 2v41G-4l9cA:
undetectable
2v41H-4l9cA:
2.4		 2v41G-4l9cA:
24.15
2v41H-4l9cA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4l9c F-BOX ONLY PROTEIN 7
(Homo
sapiens) 		3 / 3 PRO A 254
GLY A 232
TYR A 234
 None
 0.72A 2vouA-4l9cA:
undetectable		 2vouA-4l9cA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4l9c F-BOX ONLY PROTEIN 7
(Homo
sapiens) 		3 / 3 PRO A 254
GLY A 232
TYR A 234
 None
 0.73A 2vouB-4l9cA:
undetectable		 2vouB-4l9cA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4l9c F-BOX ONLY PROTEIN 7
(Homo
sapiens) 		3 / 3 PRO A 254
GLY A 232
TYR A 234
 None
 0.72A 2vouC-4l9cA:
undetectable		 2vouC-4l9cA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4l9c F-BOX ONLY PROTEIN 7
(Homo
sapiens) 		5 / 12 LEU A 301
LEU A 304
LEU A 307
GLN A 311
VAL A 313
 None
 1.29A 3zqtA-4l9cA:
undetectable		 3zqtA-4l9cA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4l9c F-BOX ONLY PROTEIN 7
(Homo
sapiens) 		3 / 3 ASN A 196
TYR A 234
CYH A 192
 None
 0.99A 5lsuB-4l9cA:
undetectable		 5lsuB-4l9cA:
18.03