SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l9m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 285
MET A 327
THR A 328
LEU A 331
 None
 0.96A 2dyrA-4l9mA:
undetectable
2dyrJ-4l9mA:
undetectable		 2dyrA-4l9mA:
21.58
2dyrJ-4l9mA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 285
MET A 327
THR A 328
LEU A 331
 None
 0.97A 2eilA-4l9mA:
undetectable
2eilJ-4l9mA:
undetectable		 2eilA-4l9mA:
21.58
2eilJ-4l9mA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 411
SER A 416
SER A 501
ASP A 408
 None
 1.18A 2obvA-4l9mA:
undetectable		 2obvA-4l9mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 417
LEU A 413
LEU A 409
ILE A 254
VAL A 281
 None
 1.28A 2qd3A-4l9mA:
undetectable		 2qd3A-4l9mA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 301
GLY A 299
VAL A 452
LEU A 285
ILE A 254
 None
 1.41A 3h52A-4l9mA:
undetectable		 3h52A-4l9mA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		3 / 3 PHE A 479
TYR A 489
LEU A 412
 None
 0.80A 3sueB-4l9mA:
undetectable		 3sueB-4l9mA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 199
ASP A 408
GLU A 404
HIS A 212
 None
 1.26A 4aq7A-4l9mA:
2.8		 4aq7A-4l9mA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 456
ASN A 252
GLU A 245
ILE A 248
 None
 0.86A 4d33A-4l9mA:
undetectable		 4d33A-4l9mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 7 SER A 456
ASN A 252
GLU A 245
ILE A 248
 None
 0.90A 4d33B-4l9mA:
undetectable		 4d33B-4l9mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 456
ASN A 252
GLU A 245
ILE A 248
 None
 0.89A 4d39A-4l9mA:
undetectable		 4d39A-4l9mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 7 SER A 456
ASN A 252
GLU A 245
ILE A 248
 None
 0.90A 4d39B-4l9mA:
undetectable		 4d39B-4l9mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 409
LEU A 413
LEU A 417
VAL A 281
ARG A 265
 None
 1.01A 4f4dA-4l9mA:
undetectable		 4f4dA-4l9mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 160
LEU A 156
ALA A 159
 None
 0.84A 4iizA-4l9mA:
undetectable		 4iizA-4l9mA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 411
SER A 416
SER A 501
ASP A 408
 None
 1.21A 4kttA-4l9mA:
undetectable		 4kttA-4l9mA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 411
SER A 416
SER A 501
ASP A 408
 None
 1.17A 4kttC-4l9mA:
undetectable		 4kttC-4l9mA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 417
TRP A 257
LEU A 413
PHE A 278
ALA A 296
 None
 1.29A 5ieoA-4l9mA:
undetectable		 5ieoA-4l9mA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 262
SER A 264
VAL A 297
PHE A 201
LEU A 209
 None
 1.04A 5tudA-4l9mA:
undetectable		 5tudA-4l9mA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A 421
ALA A 529
TYR A 533
 None
 0.84A 5uunB-4l9mA:
undetectable		 5uunB-4l9mA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A 104
TYR A 372
ASP A  63
ASP A 112
 None
 1.08A 5vlmE-4l9mA:
2.3		 5vlmE-4l9mA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 285
MET A 327
THR A 328
LEU A 331
 None
 0.96A 5x1fA-4l9mA:
undetectable
5x1fJ-4l9mA:
undetectable		 5x1fA-4l9mA:
21.58
5x1fJ-4l9mA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 5 TYR A 421
GLN A 256
GLY A 537
ILE A 532
 None
 1.25A 6debB-4l9mA:
undetectable		 6debB-4l9mA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 411
SER A 416
SER A 501
ASP A 408
 None
 1.18A 6fbnB-4l9mA:
undetectable		 6fbnB-4l9mA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 411
SER A 416
SER A 501
ASP A 408
 None
 1.19A 6fcbA-4l9mA:
undetectable		 6fcbA-4l9mA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4l9m RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 394
HIS A 389
ASN A 388
TYR A 387
 None
 0.81A 6gneB-4l9mA:
undetectable		 6gneB-4l9mA:
22.60