SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		3 / 3 VAL A2103
ALA A2104
HIS A2106
 None
 0.76A 1q23H-4l9oA:
undetectable		 1q23H-4l9oA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 11 LEU A2035
LEU A1057
SER A1058
LEU A1060
VAL A2281
 None
None
None
None
EDO  A2408 ( 4.1A)
 1.34A 2po5B-4l9oA:
undetectable		 2po5B-4l9oA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 12 LEU A1057
GLY A2032
VAL A2013
ILE A2046
ILE A1075
 None
 0.91A 2pymA-4l9oA:
undetectable		 2pymA-4l9oA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 12 LEU A1057
GLY A2032
VAL A2013
ILE A2046
ILE A1075
 None
 0.92A 2pymB-4l9oA:
undetectable		 2pymB-4l9oA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 10 HIS A2155
ALA A2161
ALA A2130
ALA A2162
SER A2178
 None
EDO  A2405 ( 3.5A)
None
None
None
 0.90A 2r2vC-4l9oA:
undetectable
2r2vF-4l9oA:
undetectable
2r2vG-4l9oA:
undetectable		 2r2vC-4l9oA:
7.32
2r2vF-4l9oA:
7.32
2r2vG-4l9oA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		3 / 3 PHE A2256
SER A2294
LEU A2283
 None
 0.81A 2w1bA-4l9oA:
undetectable		 2w1bA-4l9oA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 12 ARG A2034
ILE A1073
VAL A2057
LEU A2060
ILE A2044
 EDO  A2409 ( 4.0A)
None
None
None
None
 1.02A 3gwxB-4l9oA:
undetectable		 3gwxB-4l9oA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 12 LEU A1057
GLY A2032
VAL A2013
ILE A2046
ILE A1075
 None
 0.86A 3jvyA-4l9oA:
undetectable		 3jvyA-4l9oA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 12 LEU A1057
GLY A2032
VAL A2013
ILE A2046
ILE A1075
 None
 0.97A 3ndtD-4l9oA:
undetectable		 3ndtD-4l9oA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 12 LEU A1057
GLY A2032
VAL A2013
ILE A2046
ILE A1075
 None
 0.85A 4jecB-4l9oA:
undetectable		 4jecB-4l9oA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		3 / 3 TRP A2072
ARG A2034
LEU A2060
 EDO  A2409 (-4.6A)
EDO  A2409 ( 4.0A)
None
 0.85A 5dbyA-4l9oA:
undetectable		 5dbyA-4l9oA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		4 / 7 GLY A1077
SER A1078
GLY A1085
VAL A2013
 None
 0.32A 5izjB-4l9oA:
undetectable		 5izjB-4l9oA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		4 / 6 GLY A2179
SER A2229
THR A2227
VAL A2185
 None
 1.18A 5ysiA-4l9oA:
undetectable		 5ysiA-4l9oA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13
(Komagataella
pastoris;
Komagataella
phaffii) 		5 / 12 LEU A1057
GLY A2032
VAL A2013
ILE A1073
ILE A1075
 None
 0.88A 6dh3A-4l9oA:
undetectable		 6dh3A-4l9oA:
13.13