SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l9r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 7 SER A 290
ASP A 286
GLU A 296
GLU A 113
 None
 1.16A 1knyA-4l9rA:
undetectable
1knyB-4l9rA:
undetectable		 1knyA-4l9rA:
23.20
1knyB-4l9rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 SER A 290
ASP A 286
GLU A 296
GLU A 113
 None
 1.04A 1knyA-4l9rA:
undetectable
1knyB-4l9rA:
undetectable		 1knyA-4l9rA:
23.20
1knyB-4l9rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 TYR A 133
ILE A 237
VAL A 180
ILE A 145
ILE A 223
 None
 1.01A 1oipA-4l9rA:
2.2		 1oipA-4l9rA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		5 / 9 ALA A 100
LEU A  99
GLY A 305
PHE A 125
GLY A 124
 None
 1.28A 1ru9H-4l9rA:
undetectable
1ru9L-4l9rA:
undetectable		 1ru9H-4l9rA:
19.48
1ru9L-4l9rA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.91A 1rxcB-4l9rA:
undetectable		 1rxcB-4l9rA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.94A 1rxcE-4l9rA:
undetectable		 1rxcE-4l9rA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.90A 1rxcI-4l9rA:
undetectable		 1rxcI-4l9rA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.91A 1rxcK-4l9rA:
2.2		 1rxcK-4l9rA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 GLN A  90
VAL A 116
ILE A 109
VAL A  93
 None
 0.72A 3fi0Q-4l9rA:
undetectable		 3fi0Q-4l9rA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		5 / 11 GLN A 122
VAL A 121
TYR A 189
ILE A 307
PRO A 333
 None
 1.29A 3ganA-4l9rA:
undetectable		 3ganA-4l9rA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		5 / 10 LEU A 184
ALA A 139
GLY A 246
ILE A 247
LEU A 140
 None
 1.04A 3ogpA-4l9rA:
undetectable		 3ogpA-4l9rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		5 / 10 LEU A 184
ALA A 139
GLY A 246
ILE A 247
LEU A 140
 None
 0.95A 3ogqA-4l9rA:
undetectable		 3ogqA-4l9rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 LEU A 184
ALA A 139
GLY A 246
ILE A 247
LEU A 140
 None
 0.96A 3ogqB-4l9rA:
undetectable		 3ogqB-4l9rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.98A 4e1vA-4l9rA:
undetectable		 4e1vA-4l9rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.96A 4e1vC-4l9rA:
undetectable		 4e1vC-4l9rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.96A 4e1vD-4l9rA:
undetectable		 4e1vD-4l9rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.94A 4e1vE-4l9rA:
undetectable		 4e1vE-4l9rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.97A 4e1vG-4l9rA:
2.3		 4e1vG-4l9rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A  34
GLY A   6
ILE A   8
VAL A  70
 None
 0.97A 4e1vH-4l9rA:
undetectable		 4e1vH-4l9rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 TYR A 164
ILE A 227
THR A 173
TYR A 196
 None
 1.31A 4oltB-4l9rA:
undetectable		 4oltB-4l9rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		4 / 7 GLU A  80
ALA A 302
GLY A 305
TYR A 306
 None
 0.65A 5uxdA-4l9rA:
undetectable		 5uxdA-4l9rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 HIS A 155
ARG A 127
ILE A 237
 None
 0.74A 6fgdA-4l9rA:
3.2		 6fgdA-4l9rA:
22.15