SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4l9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		5 / 9 ASP A 113
GLU A  44
SER A 142
ALA A 143
ASP A  81
 None
MG  A 403 ( 4.6A)
None
None
None
 1.38A 1m4dB-4l9zA:
undetectable		 1m4dB-4l9zA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		4 / 7 GLY A 181
GLY A 182
ASP A 199
LEU A 164
 None
 0.80A 2oa1B-4l9zA:
undetectable		 2oa1B-4l9zA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		5 / 5 ILE A 124
LEU A  93
ASP A 118
ALA A 123
PHE A 136
 None
 1.45A 2opxA-4l9zA:
undetectable		 2opxA-4l9zA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		5 / 9 ASP A 101
VAL A  75
GLY A  97
VAL A  89
ILE A 103
 None
 1.06A 2q5kA-4l9zA:
undetectable		 2q5kA-4l9zA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		3 / 3 ARG A  76
GLU A  44
SER A 155
 OXL  A 402 ( 3.5A)
MG  A 403 ( 4.6A)
None
 0.83A 2xctD-4l9zA:
3.2		 2xctD-4l9zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		4 / 6 ILE A 217
GLN A 160
GLU A 137
TYR A  72
 None
 1.24A 2ya7C-4l9zA:
undetectable		 2ya7C-4l9zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 100
GLU A 125
LEU A  93
VAL A 121
ILE A  77
 None
 1.28A 3jw5A-4l9zA:
undetectable		 3jw5A-4l9zA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		4 / 5 ASP A 168
ASP A  45
PRO A 106
GLU A 141
 MG  A 403 ( 3.0A)
MG  A 403 ( 4.8A)
None
MG  A 403 ( 2.6A)
 1.37A 3l2uA-4l9zA:
undetectable		 3l2uA-4l9zA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		4 / 5 ASP A 168
ASP A  45
PRO A 106
GLU A 141
 MG  A 403 ( 3.0A)
MG  A 403 ( 4.8A)
None
MG  A 403 ( 2.6A)
 1.36A 3l2wA-4l9zA:
undetectable		 3l2wA-4l9zA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		4 / 4 ASP A 229
ASP A 226
GLY A 181
THR A 178
 None
 1.34A 3tl9B-4l9zA:
undetectable		 3tl9B-4l9zA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		4 / 4 ASP A 229
ASP A 226
GLY A 182
THR A 178
 None
 1.29A 3tl9B-4l9zA:
undetectable		 3tl9B-4l9zA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		5 / 9 PHE A  28
ILE A  59
ASP A 101
LEU A  73
ASN A  40
 None
 1.29A 4eb4C-4l9zA:
undetectable		 4eb4C-4l9zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		5 / 10 PHE A  28
ILE A  59
ASP A 101
LEU A  73
ASN A  40
 None
 1.29A 4eb4D-4l9zA:
undetectable		 4eb4D-4l9zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		4 / 6 PHE A  28
ILE A  59
ASP A 101
LEU A  73
 None
 1.01A 5x5qE-4l9zA:
undetectable		 5x5qE-4l9zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4l9z MALYL-COA LYASE
(Rhodobacter
sphaeroides) 		4 / 6 LEU A 164
VAL A  47
PHE A 169
GLY A 145
 None
 0.94A 6hd4B-4l9zA:
undetectable		 6hd4B-4l9zA:
12.46