SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4la2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ
(Ruegeria
lacuscaerulensis) 		5 / 12 TYR A  77
THR A  76
HIS A 125
GLY A  91
TYR A 120
 None
None
ZN  A 201 ( 3.4A)
None
MES  A 202 (-4.5A)
 1.42A 1xvaA-4la2A:
undetectable		 1xvaA-4la2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ
(Ruegeria
lacuscaerulensis) 		4 / 5 TRP A  26
PRO A  27
GLY A 109
GLY A  97
 None
 1.01A 1zlqA-4la2A:
undetectable		 1zlqA-4la2A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ
(Ruegeria
lacuscaerulensis) 		4 / 6 PHE A 175
LEU A 107
LEU A   7
ALA A  10
 None
 0.92A 2vcvB-4la2A:
undetectable		 2vcvB-4la2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ
(Ruegeria
lacuscaerulensis) 		4 / 7 TYR A 110
TYR A  92
TYR A  90
PHE A  86
 MES  A 202 ( 4.3A)
MES  A 202 (-3.8A)
None
None
 1.17A 3ku9B-4la2A:
undetectable		 3ku9B-4la2A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ
(Ruegeria
lacuscaerulensis) 		4 / 7 GLU A 128
GLU A 129
GLY A  24
ARG A 179
 None
ZN  A 201 ( 1.9A)
None
None
 0.87A 4fgzA-4la2A:
undetectable		 4fgzA-4la2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ
(Ruegeria
lacuscaerulensis) 		5 / 12 HIS A 125
TYR A 110
TRP A 178
TYR A 120
HIS A 123
 ZN  A 201 ( 3.4A)
MES  A 202 ( 4.3A)
None
MES  A 202 (-4.5A)
MES  A 202 (-3.9A)
 1.48A 4jd1A-4la2A:
undetectable
4jd1B-4la2A:
undetectable		 4jd1A-4la2A:
20.20
4jd1B-4la2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ
(Ruegeria
lacuscaerulensis) 		3 / 3 ARG A  75
GLU A  81
TYR A  90
 None
 0.78A 4r29D-4la2A:
undetectable		 4r29D-4la2A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ
(Ruegeria
lacuscaerulensis) 		3 / 3 GLU A  94
ARG A 108
TYR A 110
 None
None
MES  A 202 ( 4.3A)
 0.51A 5trqB-4la2A:
6.8		 5trqB-4la2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4la2 DIMETHYLSULPHONIOPRO
PIONATE (DMSP) LYASE
DDDQ
(Ruegeria
lacuscaerulensis) 		4 / 6 PRO A 187
HIS A 125
HIS A 163
GLU A 129
 MES  A 202 (-4.2A)
ZN  A 201 ( 3.4A)
ZN  A 201 ( 3.3A)
ZN  A 201 ( 1.9A)
 1.01A 6pahA-4la2A:
undetectable		 6pahA-4la2A:
19.24