SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 4lab RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		3 / 3 PRO A 221
LEU A 220
ARG A 212
 None
 0.84A 3aqiB-4labA:
undetectable		 3aqiB-4labA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lab RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 12 ALA A 235
ASP A 233
ILE A 218
PRO A 219
LEU A 118
 None
 0.88A 4gh8A-4labA:
undetectable		 4gh8A-4labA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4lab RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 6 ARG A 108
GLY A 107
ASP A 110
ARG A 212
 None
PT  A 302 (-3.3A)
None
None
 1.25A 4lajA-4labA:
undetectable
4lajB-4labA:
undetectable		 4lajA-4labA:
22.43
4lajB-4labA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4lab RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 7 TYR A  73
ASN A 185
TYR A 140
GLU A 139
 None
 1.20A 4mi4A-4labA:
undetectable
4mi4C-4labA:
undetectable		 4mi4A-4labA:
21.85
4mi4C-4labA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4lab RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 6 TYR A  72
GLU A 231
GLY A 228
GLY A 227
 None
 0.83A 5x7pB-4labA:
undetectable		 5x7pB-4labA:
11.98