SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A
(Homo
sapiens) 		4 / 5 TYR A 426
ILE A 408
LEU A 446
LEU A 443
 None
 1.05A 2zb7A-4lacA:
undetectable		 2zb7A-4lacA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A
(Homo
sapiens) 		5 / 11 LEU A 567
ALA A 582
GLY A 548
ILE A 547
ILE A 563
 None
 0.75A 3ebzB-4lacA:
undetectable		 3ebzB-4lacA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A
(Homo
sapiens) 		5 / 10 LEU A 567
ALA A 582
GLY A 548
ILE A 547
LEU A 564
 None
 0.85A 3ogpA-4lacA:
undetectable		 3ogpA-4lacA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A
(Homo
sapiens) 		5 / 10 LEU A 567
ALA A 582
GLY A 548
ILE A 547
LEU A 564
 None
 0.96A 3ogqA-4lacA:
undetectable		 3ogqA-4lacA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A
(Homo
sapiens) 		5 / 11 LEU A 567
ALA A 582
GLY A 548
ILE A 547
ILE A 563
 None
 0.70A 3s45B-4lacA:
undetectable		 3s45B-4lacA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A
(Homo
sapiens) 		5 / 12 THR A 481
ILE A 482
ILE A 424
ALA A 412
PHE A 439
 None
 1.26A 3vw1D-4lacA:
undetectable		 3vw1D-4lacA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A
(Homo
sapiens) 		5 / 12 LEU A 567
ALA A 582
GLY A 548
ILE A 547
ILE A 563
 None
 0.74A 5e5jA-4lacA:
undetectable		 5e5jA-4lacA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A
(Homo
sapiens) 		4 / 4 LEU A 551
ILE A 547
PRO A 523
LEU A 526
 None
 1.18A 5eb3A-4lacA:
undetectable		 5eb3A-4lacA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A
(Homo
sapiens) 		5 / 12 LEU A 567
ALA A 582
GLY A 548
ILE A 547
ILE A 563
 None
 0.73A 6dh3A-4lacA:
undetectable		 6dh3A-4lacA:
19.37