SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4laf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		4 / 8 ILE A 145
LEU A 138
PHE A 134
GLY A  81
 None
 1.05A 1os6A-4lafA:
undetectable		 1os6A-4lafA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		4 / 5 GLN A 127
THR A 120
ALA A 173
ARG A 179
 None
FMN  A 400 (-3.8A)
FMN  A 400 ( 4.1A)
None
 1.40A 2qhfA-4lafA:
undetectable		 2qhfA-4lafA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		4 / 5 VAL A  35
ILE A  64
MET A  93
ARG A 190
 None
 1.48A 3oezA-4lafA:
undetectable		 3oezA-4lafA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		4 / 8 ILE A 145
LEU A 138
PHE A 134
GLY A  81
 None
 0.96A 3selX-4lafA:
undetectable		 3selX-4lafA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		4 / 6 ILE A 145
LEU A 138
PHE A 134
GLY A  81
 None
 0.99A 3sj1X-4lafA:
undetectable		 3sj1X-4lafA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		5 / 11 LEU A 186
ALA A 169
ILE A  79
GLY A  81
ILE A  16
 None
None
None
None
FMN  A 400 (-3.8A)
 1.14A 3spkA-4lafA:
undetectable		 3spkA-4lafA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		5 / 12 LEU A 186
ALA A 169
ILE A  79
GLY A  81
ILE A  16
 None
None
None
None
FMN  A 400 (-3.8A)
 1.01A 3spkB-4lafA:
undetectable		 3spkB-4lafA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		4 / 5 GLY A 193
ILE A  79
VAL A 148
SER A 115
 None
 1.28A 4d33A-4lafA:
undetectable		 4d33A-4lafA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		4 / 7 ILE A 145
LEU A 138
PHE A 134
GLY A  81
 None
 1.05A 4hbfA-4lafA:
undetectable		 4hbfA-4lafA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		4 / 7 ILE A 145
LEU A 138
PHE A 134
GLY A  81
 None
 0.98A 4hc3A-4lafA:
undetectable		 4hc3A-4lafA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		5 / 9 THR A  84
ALA A 121
ALA A 175
GLY A 126
GLY A 125
 FMN  A 400 (-4.4A)
FMN  A 400 (-3.2A)
None
None
FMN  A 400 (-3.7A)
 1.10A 4qwuK-4lafA:
undetectable
4qwuL-4lafA:
undetectable		 4qwuK-4lafA:
21.19
4qwuL-4lafA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		5 / 9 THR A  84
ALA A 121
ALA A 175
GLY A 126
GLY A 125
 FMN  A 400 (-4.4A)
FMN  A 400 (-3.2A)
None
None
FMN  A 400 (-3.7A)
 1.15A 4qwuY-4lafA:
undetectable
4qwuZ-4lafA:
undetectable		 4qwuY-4lafA:
21.19
4qwuZ-4lafA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		5 / 12 ILE A   5
VAL A   8
PHE A  80
ILE A 199
ALA A 200
 None
 1.13A 5n0sB-4lafA:
2.1		 5n0sB-4lafA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		5 / 12 ILE A  23
GLY A 193
VAL A 148
VAL A 146
ALA A  20
 None
 1.21A 5n0wA-4lafA:
2.2		 5n0wA-4lafA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4laf NAD(P)H
DEHYDROGENASE
(QUINONE)
(Pseudomonas
sp.
WBC-3) 		5 / 12 PHE A 117
SER A 119
GLU A 185
GLY A 163
THR A 165
 None
FMN  A 400 (-2.6A)
None
None
None
 1.23A 5o4yD-4lafA:
undetectable
5o4yE-4lafA:
undetectable		 5o4yD-4lafA:
7.14
5o4yE-4lafA:
21.50