SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 12 HIS A  12
HIS A  14
ALA A 195
HIS A 251
ASP A 323
 ZN  A 401 (-4.1A)
ZN  A 401 (-4.0A)
ZN  A 401 ( 4.7A)
None
ZN  A 401 (-3.4A)
 1.02A 1a4lC-4lanA:
13.8		 1a4lC-4lanA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 7 SER A  95
PHE A 222
ALA A 195
PHE A 193
 None
None
ZN  A 401 ( 4.7A)
None
 1.11A 1fxvA-4lanA:
undetectable
1fxvB-4lanA:
undetectable		 1fxvA-4lanA:
19.74
1fxvB-4lanA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 SER A  95
PHE A 222
ALA A 195
PHE A 193
 None
None
ZN  A 401 ( 4.7A)
None
 1.10A 1gm7A-4lanA:
undetectable
1gm7B-4lanA:
undetectable		 1gm7A-4lanA:
19.74
1gm7B-4lanA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 11 LEU A  24
VAL A 116
TYR A  16
PRO A 138
PHE A 101
 None
 1.43A 1klmA-4lanA:
undetectable		 1klmA-4lanA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-3.4A)
 1.21A 1p7lD-4lanA:
undetectable		 1p7lD-4lanA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 SER A  95
ALA A 136
ILE A 163
ASN A 117
 None
 1.01A 1pnlA-4lanA:
undetectable
1pnlB-4lanA:
undetectable		 1pnlA-4lanA:
19.74
1pnlB-4lanA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-3.4A)
 1.21A 1rg9A-4lanA:
undetectable		 1rg9A-4lanA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-3.4A)
 1.20A 1rg9D-4lanA:
undetectable		 1rg9D-4lanA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 5 SER A  92
HIS A  73
ASP A 333
ASP A  85
 None
 0.94A 2oxtB-4lanA:
undetectable		 2oxtB-4lanA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 12 HIS A  12
HIS A  14
ILE A 163
HIS A 251
ASP A 323
 ZN  A 401 (-4.1A)
ZN  A 401 (-4.0A)
None
None
ZN  A 401 (-3.4A)
 0.78A 2pgrA-4lanA:
12.6		 2pgrA-4lanA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		3 / 3 LYS A   5
ARG A 369
VAL A 368
 None
 1.03A 2r2vC-4lanA:
undetectable
2r2vD-4lanA:
undetectable		 2r2vC-4lanA:
6.23
2r2vD-4lanA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 PRO A  17
SER A  19
LEU A  24
LYS A  26
 None
 1.05A 3lsfH-4lanA:
undetectable		 3lsfH-4lanA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 11 GLY A 321
LEU A 318
ARG A 317
ASN A 366
LEU A 248
 None
 1.38A 3ndvA-4lanA:
undetectable
3ndvB-4lanA:
undetectable		 3ndvA-4lanA:
23.97
3ndvB-4lanA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 11 GLY A 321
LEU A 318
ARG A 317
ASN A 366
LEU A 248
 None
 1.38A 3ndvC-4lanA:
undetectable
3ndvD-4lanA:
undetectable		 3ndvC-4lanA:
23.97
3ndvD-4lanA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 12 LEU A 104
HIS A 197
TYR A  16
LEU A  24
PRO A  31
 None
 1.03A 3okxA-4lanA:
undetectable		 3okxA-4lanA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 12 LEU A 104
HIS A 197
TYR A  16
LEU A  24
PRO A  31
 None
 1.01A 3okxB-4lanA:
undetectable		 3okxB-4lanA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 6 ALA A 260
ALA A 231
LEU A 256
THR A 227
 None
 1.10A 4dtzB-4lanA:
undetectable		 4dtzB-4lanA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 ASP A  10
VAL A 299
PHE A 193
LEU A 248
 None
 0.89A 4f8hA-4lanA:
undetectable
4f8hB-4lanA:
undetectable		 4f8hA-4lanA:
22.47
4f8hB-4lanA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 ASP A  10
VAL A 299
PHE A 193
LEU A 248
 None
 0.91A 4f8hB-4lanA:
undetectable
4f8hC-4lanA:
undetectable		 4f8hB-4lanA:
22.47
4f8hC-4lanA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 ASP A  10
VAL A 299
PHE A 193
LEU A 248
 None
 0.90A 4f8hC-4lanA:
undetectable
4f8hD-4lanA:
undetectable		 4f8hC-4lanA:
22.47
4f8hD-4lanA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 ASP A  10
VAL A 299
PHE A 193
LEU A 248
 None
 0.89A 4f8hD-4lanA:
undetectable
4f8hE-4lanA:
undetectable		 4f8hD-4lanA:
22.47
4f8hE-4lanA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 VAL A 299
PHE A 193
LEU A 248
ASP A  10
 None
 0.91A 4f8hA-4lanA:
undetectable
4f8hE-4lanA:
undetectable		 4f8hA-4lanA:
22.47
4f8hE-4lanA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 12 ALA A 195
ALA A 135
PHE A 134
LEU A 371
ILE A  11
 ZN  A 401 ( 4.7A)
None
None
None
None
 0.98A 4kjjA-4lanA:
undetectable		 4kjjA-4lanA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 5 ILE A  30
LEU A  32
ASP A  55
GLU A  50
 None
 0.84A 4nkxB-4lanA:
undetectable		 4nkxB-4lanA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 7 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-3.4A)
 1.20A 4odjA-4lanA:
undetectable		 4odjA-4lanA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 5 THR A  13
THR A 322
THR A  86
HIS A  82
 None
 1.19A 4pgfB-4lanA:
undetectable		 4pgfB-4lanA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 9 LEU A 373
GLY A 364
VAL A  91
SER A  92
VAL A  93
 None
 1.13A 4qd3A-4lanA:
undetectable		 4qd3A-4lanA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 11 LEU A 169
LEU A 139
LEU A 178
GLU A 183
ALA A 184
 None
 1.14A 4wg0F-4lanA:
undetectable
4wg0G-4lanA:
undetectable
4wg0H-4lanA:
undetectable		 4wg0F-4lanA:
2.93
4wg0G-4lanA:
2.93
4wg0H-4lanA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 9 VAL A 153
LEU A 137
ALA A 136
VAL A 185
ILE A 150
 None
 1.17A 5om2A-4lanA:
undetectable
5om2B-4lanA:
undetectable		 5om2A-4lanA:
12.26
5om2B-4lanA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-3.4A)
 1.18A 5t8sB-4lanA:
undetectable		 5t8sB-4lanA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		3 / 3 GLU A 225
TRP A 100
HIS A 251
 None
 1.07A 5xipA-4lanA:
undetectable		 5xipA-4lanA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		4 / 8 HIS A 251
ASP A 297
PHE A 193
ASP A 323
 None
None
None
ZN  A 401 (-3.4A)
 1.19A 6fbnB-4lanA:
undetectable		 6fbnB-4lanA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 12 HIS A  14
ILE A 163
ALA A 195
HIS A 251
ASP A 323
 ZN  A 401 (-4.0A)
None
ZN  A 401 ( 4.7A)
None
ZN  A 401 (-3.4A)
 0.95A 6n91A-4lanA:
7.6		 6n91A-4lanA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE
(Cordyceps
militaris) 		5 / 12 HIS A  14
ILE A 163
ALA A 195
HIS A 251
ASP A 323
 ZN  A 401 (-4.0A)
None
ZN  A 401 ( 4.7A)
None
ZN  A 401 (-3.4A)
 0.94A 6n91B-4lanA:
7.8		 6n91B-4lanA:
12.27