SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4laq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		5 / 12 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.33A 1e7wA-4laqH:
undetectable		 1e7wA-4laqH:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 8 ARG H  66
LYS H  82
LEU H  82
GLN H  81
 None
 0.87A 1v54C-4laqH:
undetectable
1v54J-4laqH:
undetectable		 1v54C-4laqH:
19.77
1v54J-4laqH:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 8 ARG H  66
LYS H  82
LEU H  82
GLN H  81
 None
 0.87A 2dyrC-4laqH:
undetectable
2dyrJ-4laqH:
undetectable		 2dyrC-4laqH:
19.77
2dyrJ-4laqH:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		5 / 7 TYR H  94
GLY H  26
THR H  25
TYR H 102
ASP H  27
 None
 1.48A 2g70B-4laqH:
undetectable		 2g70B-4laqH:
16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GKZ_A_B40A500_1
(ANTI-METHAMPHETAMINE
SINGLE CHAIN FV)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		6 / 11 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
 None
 0.67A 3gkzA-4laqH:
17.1		 3gkzA-4laqH:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GM0_A_B41A600_1
(ANTI-METHAMPHETAMINE
SINGLE CHAIN FV)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		6 / 11 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
 None
 0.68A 3gm0A-4laqH:
16.9		 3gm0A-4laqH:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GQP_H_B40H1201_1
(ANTI-METH SCFV)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		6 / 11 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
 None
 0.67A 4gqpH-4laqH:
17.2		 4gqpH-4laqH:
99.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LAR_L_1WEL300_1
(SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		6 / 10 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
 None
 0.69A 4larH-4laqH:
17.0
4larL-4laqH:
10.4		 4larH-4laqH:
100.00
4larL-4laqH:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 4 TYR H  59
THR H  57
GLY H  49
LEU H  80
 None
 1.36A 4w5nA-4laqH:
undetectable		 4w5nA-4laqH:
7.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 7 TYR H  94
SER H  35
TYR H  47
TYR H  33
 None
 0.95A 5aclA-4laqH:
12.1		 5aclA-4laqH:
34.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 5 GLY H  32
ARG H  71
ASP H  96
MET H 100
 None
 1.46A 5ubbA-4laqH:
undetectable		 5ubbA-4laqH:
19.31