SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4law'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.56A 1bkfA-4lawA:
19.3		 1bkfA-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 9 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.60A 1bkfA-4lawA:
19.3		 1bkfA-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 12 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 (-4.3A)
 0.50A 1c9hA-4lawA:
18.7		 1c9hA-4lawA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
None
None
DMS  A 304 (-4.3A)
 0.57A 1c9hA-4lawA:
18.7		 1c9hA-4lawA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		10 / 12 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.69A 1fapA-4lawA:
19.4		 1fapA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 12 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
None
DMS  A 304 (-4.3A)
 0.87A 1fapA-4lawA:
19.4		 1fapA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.55A 1fkbA-4lawA:
19.6		 1fkbA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		6 / 12 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A 122
 None
None
None
None
DMS  A 304 (-3.5A)
None
 0.85A 1fkbA-4lawA:
19.6		 1fkbA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.55A 1fkbA-4lawA:
19.6		 1fkbA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.78A 1fkfA-4lawA:
19.3		 1fkfA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.83A 1fkfA-4lawA:
19.3		 1fkfA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.78A 1fkjA-4lawA:
19.4		 1fkjA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.83A 1fkjA-4lawA:
19.4		 1fkjA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.56A 1fklA-4lawA:
19.6		 1fklA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		6 / 12 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A 122
 None
None
None
None
DMS  A 304 (-3.5A)
None
 0.86A 1fklA-4lawA:
19.6		 1fklA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 12 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.57A 1fklA-4lawA:
19.6		 1fklA-4lawA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBK_A_RAPA225_1
(FKBP25)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 12 TYR A  57
ASP A  68
GLY A  82
TRP A  90
PHE A 130
 None
None
None
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.95A 1pbkA-4lawA:
19.2		 1pbkA-4lawA:
33.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBK_A_RAPA225_1
(FKBP25)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
ASP A  68
GLY A  84
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.65A 1pbkA-4lawA:
19.2		 1pbkA-4lawA:
33.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PBK_A_RAPA225_1
(FKBP25)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
GLY A  84
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.50A 1pbkA-4lawA:
19.2		 1pbkA-4lawA:
33.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 9 TYR A  57
ASP A  68
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.70A 1q6iA-4lawA:
16.7		 1q6iA-4lawA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 9 TYR A  57
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.63A 1q6iA-4lawA:
16.7		 1q6iA-4lawA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ASP A  68
ARG A  73
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.75A 1q6iB-4lawA:
16.4		 1q6iB-4lawA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 12 ILE A 122
ILE A  25
ILE A 105
VAL A 129
ILE A  87
 None
None
None
None
DMS  A 304 (-3.8A)
 1.28A 1r5lA-4lawA:
undetectable		 1r5lA-4lawA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.76A 1tcoC-4lawA:
19.1		 1tcoC-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.87A 1tcoC-4lawA:
19.1		 1tcoC-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.74A 1yatA-4lawA:
20.8		 1yatA-4lawA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.80A 1yatA-4lawA:
20.8		 1yatA-4lawA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 11 TYR A  57
ASP A  68
PHE A  77
GLU A  85
ILE A 122
 None
 0.87A 2dg3A-4lawA:
19.3		 2dg3A-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.51A 2dg3A-4lawA:
19.3		 2dg3A-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.55A 2dg3A-4lawA:
19.3		 2dg3A-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 (-4.3A)
 0.56A 2dg4A-4lawA:
18.7		 2dg4A-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		6 / 11 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A 122
 None
None
None
None
DMS  A 304 (-3.5A)
None
 0.84A 2dg4A-4lawA:
18.7		 2dg4A-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
None
DMS  A 304 (-4.3A)
 0.57A 2dg4A-4lawA:
18.7		 2dg4A-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		6 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 (-4.3A)
 0.52A 2dg9A-4lawA:
19.0		 2dg9A-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
None
None
DMS  A 304 (-3.5A)
None
 0.92A 2dg9A-4lawA:
19.0		 2dg9A-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		6 / 11 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
None
DMS  A 304 (-4.3A)
 0.47A 2dg9A-4lawA:
19.0		 2dg9A-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.75A 2fkeA-4lawA:
19.3		 2fkeA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.80A 2fkeA-4lawA:
19.3		 2fkeA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
PHE A  67
ASP A  68
VAL A  86
ILE A  87
TRP A  90
TYR A 113
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
 0.80A 2vcdA-4lawA:
14.0		 2vcdA-4lawA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 11 TYR A  57
PHE A  67
PHE A  77
TRP A  90
TYR A 113
 None
None
None
DMS  A 304 ( 4.0A)
None
 1.29A 2vcdA-4lawA:
14.0		 2vcdA-4lawA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
PHE A  67
ARG A  73
PHE A  77
VAL A  86
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.87A 2vn1A-4lawA:
21.0		 2vn1A-4lawA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
PHE A  67
ASP A  68
ARG A  73
PHE A  77
VAL A  86
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.92A 2vn1A-4lawA:
21.0		 2vn1A-4lawA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.74A 2vn1B-4lawA:
20.9		 2vn1B-4lawA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.75A 2vn1B-4lawA:
20.9		 2vn1B-4lawA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		4 / 7 ARG A 157
GLY A 139
VAL A  53
ASP A 141
 DMS  A 302 (-4.0A)
None
None
None
 0.80A 2y05A-4lawA:
undetectable
2y05B-4lawA:
undetectable		 2y05A-4lawA:
21.62
2y05B-4lawA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		3 / 3 THR A  58
SER A  69
PHE A 135
 None
 0.80A 3d4sA-4lawA:
undetectable		 3d4sA-4lawA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		3 / 3 ALA A  93
THR A  96
CYH A 103
 None
 0.77A 3e4eA-4lawA:
undetectable		 3e4eA-4lawA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.70A 3ihzA-4lawA:
20.8		 3ihzA-4lawA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.77A 3ihzA-4lawA:
20.8		 3ihzA-4lawA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		6 / 8 TYR A  57
ASP A  68
PHE A  77
TRP A  90
TYR A 113
ILE A 122
 None
None
None
DMS  A 304 ( 4.0A)
None
None
 0.46A 3ihzB-4lawA:
21.1		 3ihzB-4lawA:
23.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 10 TYR A  57
ASP A  68
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.66A 3kz7A-4lawA:
19.4		 3kz7A-4lawA:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 10 TYR A  57
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.53A 3kz7A-4lawA:
19.4		 3kz7A-4lawA:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.68A 3o5rA-4lawA:
22.5		 3o5rA-4lawA:
67.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.79A 3o5rA-4lawA:
22.5		 3o5rA-4lawA:
67.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		3 / 3 LYS A 138
ARG A  52
ASP A 147
 None
 1.09A 3o7wA-4lawA:
undetectable		 3o7wA-4lawA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 10 PRO A 201
GLY A 176
TYR A 245
GLY A 228
ALA A 226
 None
 1.29A 3pp7B-4lawA:
undetectable		 3pp7B-4lawA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.71A 3uf8A-4lawA:
19.2		 3uf8A-4lawA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.79A 3uf8A-4lawA:
19.2		 3uf8A-4lawA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.77A 3uqaA-4lawA:
16.0		 3uqaA-4lawA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.86A 3uqaA-4lawA:
16.0		 3uqaA-4lawA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.56A 3uqbA-4lawA:
19.1		 3uqbA-4lawA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.76A 3vawA-4lawA:
15.7		 3vawA-4lawA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.83A 3vawA-4lawA:
15.7		 3vawA-4lawA:
24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.72A 4drhA-4lawA:
21.2		 4drhA-4lawA:
59.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.50A 4drhA-4lawA:
21.2		 4drhA-4lawA:
59.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.65A 4drhD-4lawA:
21.1		 4drhD-4lawA:
59.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.44A 4drhD-4lawA:
21.1		 4drhD-4lawA:
59.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.65A 4driA-4lawA:
23.5		 4driA-4lawA:
59.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.78A 4driA-4lawA:
23.5		 4driA-4lawA:
59.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.62A 4drjA-4lawA:
23.7		 4drjA-4lawA:
87.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.49A 4drjA-4lawA:
23.7		 4drjA-4lawA:
87.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ARG A  73
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.90A 4dz2A-4lawA:
19.1
4dz2B-4lawA:
19.2		 4dz2A-4lawA:
30.73
4dz2B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.68A 4dz2A-4lawA:
19.1
4dz2B-4lawA:
19.2		 4dz2A-4lawA:
30.73
4dz2B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.53A 4dz2A-4lawA:
19.1
4dz2B-4lawA:
19.2		 4dz2A-4lawA:
30.73
4dz2B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ARG A  73
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.87A 4dz2A-4lawA:
19.1
4dz2B-4lawA:
19.2		 4dz2A-4lawA:
30.73
4dz2B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.68A 4dz2A-4lawA:
19.1
4dz2B-4lawA:
19.2		 4dz2A-4lawA:
30.73
4dz2B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.53A 4dz2A-4lawA:
19.1
4dz2B-4lawA:
19.2		 4dz2A-4lawA:
30.73
4dz2B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ARG A  73
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.83A 4dz3A-4lawA:
19.3		 4dz3A-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ASP A  68
ARG A  73
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.95A 4dz3A-4lawA:
19.3		 4dz3A-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.68A 4dz3A-4lawA:
19.3		 4dz3A-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.52A 4dz3A-4lawA:
19.3		 4dz3A-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ARG A  73
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.72A 4dz3B-4lawA:
19.3		 4dz3B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ASP A  68
ARG A  73
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.85A 4dz3B-4lawA:
19.3		 4dz3B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.70A 4dz3B-4lawA:
19.3		 4dz3B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.55A 4dz3B-4lawA:
19.3		 4dz3B-4lawA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.63A 4laxA-4lawA:
33.0		 4laxA-4lawA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.48A 4laxA-4lawA:
33.0		 4laxA-4lawA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.65A 4nnrA-4lawA:
15.8
4nnrB-4lawA:
15.8		 4nnrA-4lawA:
32.62
4nnrB-4lawA:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.51A 4nnrA-4lawA:
15.8
4nnrB-4lawA:
15.8		 4nnrA-4lawA:
32.62
4nnrB-4lawA:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.71A 4nnrB-4lawA:
15.8		 4nnrB-4lawA:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.54A 4nnrB-4lawA:
15.8		 4nnrB-4lawA:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 12 TYR A  57
ASP A  68
ILE A  87
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.8A)
None
DMS  A 304 (-4.3A)
 0.72A 4odrA-4lawA:
12.5
4odrB-4lawA:
12.6		 4odrA-4lawA:
17.95
4odrB-4lawA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 12 TYR A  57
ILE A  87
TYR A 113
ILE A 122
PHE A 130
 None
DMS  A 304 (-3.8A)
None
None
DMS  A 304 (-4.3A)
 0.53A 4odrA-4lawA:
12.5
4odrB-4lawA:
12.6		 4odrA-4lawA:
17.95
4odrB-4lawA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.52A 4qt2A-4lawA:
21.1		 4qt2A-4lawA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.48A 4qt2A-4lawA:
21.1		 4qt2A-4lawA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.64A 4qt3A-4lawA:
19.9		 4qt3A-4lawA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.53A 4qt3A-4lawA:
19.9		 4qt3A-4lawA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 12 ILE A 192
ALA A 168
ALA A 162
ASN A 165
PHE A 190
 None
 1.48A 4zo1X-4lawA:
undetectable		 4zo1X-4lawA:
23.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 12 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.79A 5b8iC-4lawA:
18.3		 5b8iC-4lawA:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 12 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.90A 5b8iC-4lawA:
18.3		 5b8iC-4lawA:
30.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
ASP A  68
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.62A 5d75A-4lawA:
19.2		 5d75A-4lawA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.58A 5d75A-4lawA:
19.2		 5d75A-4lawA:
27.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
ASP A  68
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.66A 5gpgA-4lawA:
20.0		 5gpgA-4lawA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.49A 5gpgA-4lawA:
20.0		 5gpgA-4lawA:
33.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 12 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 (-4.3A)
 0.53A 5hkgA-4lawA:
19.1		 5hkgA-4lawA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 12 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
None
None
DMS  A 304 (-4.3A)
 0.57A 5hkgA-4lawA:
19.1		 5hkgA-4lawA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.72A 5huaA-4lawA:
21.0		 5huaA-4lawA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.80A 5huaA-4lawA:
21.0		 5huaA-4lawA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
 0.92A 5hw8A-4lawA:
17.7
5hw8D-4lawA:
18.0		 5hw8A-4lawA:
27.18
5hw8D-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
 0.74A 5hw8A-4lawA:
17.7
5hw8D-4lawA:
18.0		 5hw8A-4lawA:
27.18
5hw8D-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.92A 5hw8B-4lawA:
17.7		 5hw8B-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
None
None
DMS  A 304 (-3.5A)
None
 1.12A 5hw8B-4lawA:
17.7		 5hw8B-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.69A 5hw8B-4lawA:
17.7		 5hw8B-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ARG A  73
VAL A  86
ILE A  87
TRP A  90
TYR A 113
LEU A 128
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.83A 5hw8C-4lawA:
17.6
5hw8H-4lawA:
14.8		 5hw8C-4lawA:
27.18
5hw8H-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 10 TYR A  57
ASP A  68
ARG A  73
VAL A  86
ILE A  87
TRP A  90
LEU A 128
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.84A 5hw8C-4lawA:
17.6
5hw8H-4lawA:
14.8		 5hw8C-4lawA:
27.18
5hw8H-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.70A 5hw8D-4lawA:
18.0		 5hw8D-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.77A 5hw8D-4lawA:
18.0		 5hw8D-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
None
None
DMS  A 304 (-3.5A)
None
 1.07A 5hw8D-4lawA:
18.0		 5hw8D-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
ARG A  73
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.82A 5hw8E-4lawA:
18.1		 5hw8E-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
ASP A  68
ARG A  73
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.96A 5hw8E-4lawA:
18.1		 5hw8E-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.66A 5hw8E-4lawA:
18.1		 5hw8E-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
None
None
DMS  A 304 (-3.5A)
None
 1.13A 5hw8E-4lawA:
18.1		 5hw8E-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
 1.42A 5hw8E-4lawA:
18.1		 5hw8E-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.56A 5hw8E-4lawA:
18.1		 5hw8E-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 12 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.61A 5hw8B-4lawA:
17.7
5hw8F-4lawA:
14.9
5hw8G-4lawA:
17.3		 5hw8B-4lawA:
27.18
5hw8F-4lawA:
27.18
5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		5 / 12 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
None
None
DMS  A 304 (-3.5A)
None
 1.12A 5hw8B-4lawA:
17.7
5hw8F-4lawA:
14.9
5hw8G-4lawA:
17.3		 5hw8B-4lawA:
27.18
5hw8F-4lawA:
27.18
5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 12 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.44A 5hw8B-4lawA:
17.7
5hw8F-4lawA:
14.9
5hw8G-4lawA:
17.3		 5hw8B-4lawA:
27.18
5hw8F-4lawA:
27.18
5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		6 / 12 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TYR A 113
ILE A 122
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
None
None
 1.43A 5hw8B-4lawA:
17.7
5hw8F-4lawA:
14.9
5hw8G-4lawA:
17.3		 5hw8B-4lawA:
27.18
5hw8F-4lawA:
27.18
5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.71A 5hw8G-4lawA:
17.3		 5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 11 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
 1.36A 5hw8G-4lawA:
17.3		 5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		8 / 11 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.59A 5hw8G-4lawA:
17.3		 5hw8G-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		4 / 8 TYR A  57
ASP A  68
PHE A  77
ILE A 122
 None
 0.94A 5hw8H-4lawA:
14.8		 5hw8H-4lawA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		7 / 8 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.69A 5hw8H-4lawA:
14.8		 5hw8H-4lawA:
27.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
ARG A  73
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.84A 5hwcA-4lawA:
19.1		 5hwcA-4lawA:
31.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 11 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.59A 5hwcA-4lawA:
19.1		 5hwcA-4lawA:
31.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 12 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.72A 6mkeA-4lawA:
21.2
6mkeD-4lawA:
21.2		 6mkeA-4lawA:
16.06
6mkeD-4lawA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 12 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.77A 6mkeA-4lawA:
21.2
6mkeD-4lawA:
21.2		 6mkeA-4lawA:
16.06
6mkeD-4lawA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 12 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.76A 6mkeB-4lawA:
21.0
6mkeC-4lawA:
20.9		 6mkeB-4lawA:
16.06
6mkeC-4lawA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 12 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.81A 6mkeB-4lawA:
21.0
6mkeC-4lawA:
20.9		 6mkeB-4lawA:
16.06
6mkeC-4lawA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.74A 6mkeC-4lawA:
20.9		 6mkeC-4lawA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.81A 6mkeC-4lawA:
20.9		 6mkeC-4lawA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
 0.74A 6mkeD-4lawA:
21.2		 6mkeD-4lawA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens) 		9 / 10 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.80A 6mkeD-4lawA:
21.2		 6mkeD-4lawA:
16.06