SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lb8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4lb8 UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 ALA A  90
ASP A  91
GLU A  93
MET A 149
 None
 0.80A 2ouzA-4lb8A:
undetectable		 2ouzA-4lb8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4lb8 UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 SER A 184
VAL A 308
GLY A 202
ILE A 293
VAL A 237
 None
 1.12A 2uxpB-4lb8A:
undetectable		 2uxpB-4lb8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4lb8 UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 291
THR A 290
VAL A 308
ILE A 189
SER A 184
 None
 1.18A 3kpcA-4lb8A:
undetectable		 3kpcA-4lb8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4lb8 UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 291
THR A 290
VAL A 308
ILE A 189
SER A 184
 None
 1.19A 3kpdB-4lb8A:
undetectable		 3kpdB-4lb8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4lb8 UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		6 / 12 PHE A 264
PHE A 216
ALA A 265
ALA A 235
VAL A 308
LEU A 239
 None
 1.43A 4j6dB-4lb8A:
undetectable		 4j6dB-4lb8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 4lb8 UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 168
TYR A 135
THR A 130
ILE A 127
 None
 0.94A 4jx1E-4lb8A:
undetectable		 4jx1E-4lb8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4lb8 UNCHARACTERIZED
PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 214
LEU A 205
ALA A 265
ILE A 266
GLY A 280
 None
None
None
PEG  A 406 (-4.6A)
None
 0.98A 4r3aB-4lb8A:
undetectable		 4r3aB-4lb8A:
23.37