SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		3 / 3 TRP A 200
ALA A  30
VAL A 196
 None
 0.87A 1c4dA-4lbwA:
undetectable
1c4dB-4lbwA:
undetectable		 1c4dA-4lbwA:
2.50
1c4dB-4lbwA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 4 ARG A 244
ALA A 305
ALA A 379
GLU A 381
 None
 1.00A 1e7bA-4lbwA:
undetectable		 1e7bA-4lbwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 4 ARG A 244
ALA A 305
ALA A 379
GLU A 381
 None
 1.00A 1e7bB-4lbwA:
undetectable		 1e7bB-4lbwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 5 ARG A 244
ALA A 305
ALA A 379
GLU A 381
 None
 1.00A 1e7cA-4lbwA:
undetectable		 1e7cA-4lbwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 ILE A 131
TYR A 209
LEU A 202
HIS A 119
ILE A 206
 None
 1.11A 1fmlB-4lbwA:
undetectable		 1fmlB-4lbwA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 9 THR A 262
VAL A 303
GLU A 254
ARG A 244
ILE A 310
 None
 1.33A 1nb9A-4lbwA:
1.3		 1nb9A-4lbwA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 7 PHE A 221
VAL A 286
GLY A 287
VAL A 267
 None
 0.94A 1t88A-4lbwA:
undetectable		 1t88A-4lbwA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		3 / 3 ALA A 175
VAL A 196
TRP A 200
 GNP  A 501 (-4.1A)
None
None
 0.81A 1tkqB-4lbwA:
undetectable		 1tkqB-4lbwA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 10 ALA A 387
LEU A 122
GLN A 125
GLU A 162
MET A  99
 None
 1.45A 1wrlC-4lbwA:
undetectable
1wrlD-4lbwA:
undetectable		 1wrlC-4lbwA:
15.34
1wrlD-4lbwA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 TYR A  70
LEU A 203
VAL A  12
HIS A  11
ALA A 102
 None
 1.40A 2g72A-4lbwA:
undetectable		 2g72A-4lbwA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 GLY A  15
VAL A 133
ALA A 123
LEU A 122
MET A  99
 None
 1.06A 2oz7A-4lbwA:
undetectable		 2oz7A-4lbwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 LEU A 203
LEU A 202
ARG A  75
VAL A 105
VAL A  14
 None
 1.29A 2qd4A-4lbwA:
4.1		 2qd4A-4lbwA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 VAL A 105
ASP A  81
HIS A  79
ASN A 136
 None
MG  A 502 ( 4.0A)
None
GNP  A 501 (-3.2A)
 1.16A 2zs9A-4lbwA:
2.5		 2zs9A-4lbwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 THR A 347
VAL A 228
VAL A 293
ILE A 255
THR A 236
 None
 1.15A 3czhA-4lbwA:
undetectable		 3czhA-4lbwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 THR A 347
VAL A 228
VAL A 293
ILE A 255
THR A 236
 None
 1.13A 3dl9A-4lbwA:
undetectable		 3dl9A-4lbwA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 8 ARG A 389
ALA A 387
ILE A 388
PRO A 340
 None
 0.96A 3fxrA-4lbwA:
1.3		 3fxrA-4lbwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 10 GLN A 125
LEU A 374
VAL A 349
VAL A 378
LEU A 380
 None
 0.99A 3gwxA-4lbwA:
undetectable		 3gwxA-4lbwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 PHE A 344
PHE A 316
HIS A 313
VAL A 378
 None
 1.31A 3lb3A-4lbwA:
undetectable		 3lb3A-4lbwA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 PHE A 344
PHE A 316
HIS A 313
VAL A 378
 None
 1.27A 3lb3B-4lbwA:
undetectable		 3lb3B-4lbwA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 8 ARG A   7
VAL A 286
MET A 272
ILE A 242
 None
 1.03A 3remA-4lbwA:
undetectable		 3remA-4lbwA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 8 ARG A   7
VAL A 286
MET A 272
ILE A 242
 None
 1.02A 3remB-4lbwA:
undetectable		 3remB-4lbwA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 9 PHE A 386
GLY A 329
GLY A 396
LEU A 323
GLU A 327
 None
 1.34A 4l8wI-4lbwA:
4.9		 4l8wI-4lbwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 ALA A  29
ASP A  81
LEU A 179
SER A 174
 None
MG  A 502 ( 4.0A)
None
GNP  A 501 (-2.7A)
 1.15A 4ot2A-4lbwA:
undetectable		 4ot2A-4lbwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 9 ALA A 123
GLY A  15
ALA A 102
ILE A 120
VAL A 105
 None
 1.06A 4r21B-4lbwA:
undetectable		 4r21B-4lbwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 ASP A  51
ALA A  66
THR A  25
THR A  28
 MG  A 502 (-4.0A)
NH4  A 503 ( 4.0A)
MG  A 502 ( 3.1A)
None
 1.46A 4w5qA-4lbwA:
5.3		 4w5qA-4lbwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 ASP A  51
ALA A  66
THR A  25
THR A  28
 MG  A 502 (-4.0A)
NH4  A 503 ( 4.0A)
MG  A 502 ( 3.1A)
None
 1.49A 4w5rA-4lbwA:
5.3		 4w5rA-4lbwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 ASP A  51
ALA A  66
THR A  25
THR A  28
 MG  A 502 (-4.0A)
NH4  A 503 ( 4.0A)
MG  A 502 ( 3.1A)
None
 1.50A 4w5tA-4lbwA:
5.3		 4w5tA-4lbwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 LEU A 122
LEU A 158
VAL A 133
VAL A 128
PHE A 163
 None
 1.11A 4wnwA-4lbwA:
undetectable		 4wnwA-4lbwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 ASN A 136
ASP A  21
THR A  16
VAL A 105
 GNP  A 501 (-3.2A)
GNP  A 501 (-3.4A)
None
None
 1.14A 4yoaA-4lbwA:
undetectable		 4yoaA-4lbwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 ASP A  51
ALA A  66
THR A  25
THR A  28
 MG  A 502 (-4.0A)
NH4  A 503 ( 4.0A)
MG  A 502 ( 3.1A)
None
 1.46A 4z4fA-4lbwA:
5.2		 4z4fA-4lbwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 5 ASP A  51
ALA A  66
THR A  25
THR A  28
 MG  A 502 (-4.0A)
NH4  A 503 ( 4.0A)
MG  A 502 ( 3.1A)
None
 1.50A 4z4gA-4lbwA:
undetectable		 4z4gA-4lbwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 9 PHE A 221
VAL A 288
GLY A 287
THR A 239
VAL A 225
 None
 1.31A 5cp4A-4lbwA:
undetectable		 5cp4A-4lbwA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 ILE A 131
GLY A 165
ARG A 155
GLU A 327
LEU A 157
 None
 1.14A 5fhzD-4lbwA:
undetectable		 5fhzD-4lbwA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 GLN A  98
ALA A 102
VAL A 128
LEU A  31
ILE A  50
 None
 1.17A 5hv1A-4lbwA:
undetectable		 5hv1A-4lbwA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 8 HIS A 273
HIS A  76
HIS A  11
GLY A 283
 SO4  A 505 (-4.0A)
None
None
None
 0.88A 5m8rC-4lbwA:
undetectable		 5m8rC-4lbwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 9 PRO A 169
TYR A 209
ILE A 210
ILE A 206
ILE A 103
 None
 1.31A 5mzrD-4lbwA:
undetectable		 5mzrD-4lbwA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 GLY A 351
PHE A 342
VAL A 359
VAL A 320
ILE A 388
 None
 1.38A 5tuiB-4lbwA:
undetectable		 5tuiB-4lbwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		3 / 3 ASP A 100
ASN A  13
ASP A 284
 None
 0.86A 5vopA-4lbwA:
2.6		 5vopA-4lbwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		3 / 3 ASP A 100
ASN A  13
ASP A 284
 None
 0.84A 5vopB-4lbwA:
3.1		 5vopB-4lbwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 HIS A  11
VAL A  80
LEU A 304
PHE A 221
GLY A 283
 None
 1.40A 6brdA-4lbwA:
undetectable		 6brdA-4lbwA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		5 / 12 ASP A 227
GLU A 226
GLN A  98
ILE A  50
THR A  62
 None
None
None
None
MG  A 502 (-2.9A)
 1.49A 6fzbB-4lbwA:
undetectable		 6fzbB-4lbwA:
12.85