SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  69
LEU A  65
SER A 180
SER A  86
VAL A  80
 None
None
None
EDO  A 403 (-2.8A)
None
 1.27A 1db1A-4lc3A:
undetectable		 1db1A-4lc3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A 171
LEU A 250
LEU A  46
ALA A 196
PHE A 183
 None
 1.08A 1gseB-4lc3A:
undetectable		 1gseB-4lc3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  69
LEU A  65
SER A 180
SER A  86
VAL A  80
 None
None
None
EDO  A 403 (-2.8A)
None
 1.33A 1ie9A-4lc3A:
undetectable		 1ie9A-4lc3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 THR A  64
VAL A  93
GLU A  66
SER A 180
ASP A 158
 None
None
None
None
EDO  A 403 (-3.6A)
 1.20A 1jdvE-4lc3A:
undetectable
1jdvF-4lc3A:
undetectable		 1jdvE-4lc3A:
18.53
1jdvF-4lc3A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 ASN A 375
LEU A 276
LEU A 297
MET A 313
LEU A 356
 None
 1.39A 2aa6B-4lc3A:
undetectable		 2aa6B-4lc3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 10 ARG A 171
LEU A 247
LEU A  46
ALA A  45
VAL A  55
 None
 0.98A 2bxgB-4lc3A:
undetectable		 2bxgB-4lc3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 ASN A 375
LEU A 276
LEU A 297
MET A 313
LEU A 356
 None
 1.35A 2oaxD-4lc3A:
undetectable		 2oaxD-4lc3A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 ASN A 375
LEU A 276
LEU A 297
MET A 313
LEU A 356
 None
 1.33A 2oaxE-4lc3A:
undetectable		 2oaxE-4lc3A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		3 / 3 TYR A 324
ASP A 158
HIS A 184
 EDO  A 403 ( 4.0A)
EDO  A 403 (-3.6A)
CIT  A 401 (-4.0A)
 0.89A 3e23A-4lc3A:
1.9		 3e23A-4lc3A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 6 THR A  97
ARG A  70
LEU A  69
GLY A  68
ALA A  99
 None
 1.39A 3huoA-4lc3A:
undetectable		 3huoA-4lc3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		3 / 3 SER A  60
GLY A  61
THR A  62
 CIT  A 401 (-3.8A)
CIT  A 401 (-3.5A)
CIT  A 401 ( 3.7A)
 0.22A 3k9wA-4lc3A:
undetectable		 3k9wA-4lc3A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 9 LEU A  65
GLY A 176
PRO A 131
ILE A 130
ILE A 156
 None
 1.01A 3s56B-4lc3A:
undetectable		 3s56B-4lc3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 10 VAL A 179
ILE A 172
GLY A 164
ALA A 196
VAL A 198
 None
 0.98A 3t3cB-4lc3A:
undetectable		 3t3cB-4lc3A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 11 THR A  83
ALA A 104
LEU A 118
VAL A  74
ILE A  94
 None
 1.42A 4claA-4lc3A:
undetectable		 4claA-4lc3A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 SER A  60
GLY A  68
ASP A 158
ALA A 128
VAL A  80
 CIT  A 401 (-3.8A)
None
EDO  A 403 (-3.6A)
None
None
 0.98A 4dx5B-4lc3A:
undetectable		 4dx5B-4lc3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A 371
TYR A 264
ALA A 267
 None
 0.40A 4ybnA-4lc3A:
undetectable		 4ybnA-4lc3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 6 ILE A 156
ARG A 154
ILE A  71
GLU A 204
 None
 1.35A 4zzcB-4lc3A:
undetectable
4zzcC-4lc3A:
undetectable		 4zzcB-4lc3A:
23.89
4zzcC-4lc3A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 5 GLU A  66
THR A  97
THR A  82
HIS A 328
 None
 1.27A 5axaA-4lc3A:
2.5		 5axaA-4lc3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 5 GLU A  66
THR A  97
THR A  82
HIS A 328
 None
 1.30A 5axaC-4lc3A:
undetectable		 5axaC-4lc3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 4 TYR A 324
GLY A 136
SER A 135
LEU A 134
 EDO  A 403 ( 4.0A)
None
None
None
 1.40A 5bphC-4lc3A:
undetectable		 5bphC-4lc3A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		3 / 3 PHE A 253
ARG A 257
GLN A 256
 None
 1.18A 6g1pB-4lc3A:
undetectable		 6g1pB-4lc3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 6 ASP A 116
ASP A 114
ARG A 143
GLN A 120
 None
None
EDO  A 404 (-4.6A)
None
 1.42A 6g31L-4lc3A:
undetectable		 6g31L-4lc3A:
12.62