SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lcb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		4 / 6 HIS A 313
ILE A 331
LYS A 337
VAL A 288
 None
 0.99A 1hk1A-4lcbA:
2.6		 1hk1A-4lcbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		5 / 11 LEU A 133
ALA A 149
ALA A 145
VAL A 264
LEU A 102
 None
 1.08A 1rlbF-4lcbA:
undetectable		 1rlbF-4lcbA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		3 / 3 ASP A 227
PHE A 180
ASN A 220
 None
 0.75A 1sg9B-4lcbA:
undetectable		 1sg9B-4lcbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		3 / 3 PRO A 247
GLU A 356
TYR A 355
 None
 0.77A 2zmbA-4lcbA:
undetectable		 2zmbA-4lcbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		5 / 12 LEU A 133
ALA A 108
PRO A 265
VAL A 264
ILE A 262
 None
 1.04A 3cyxA-4lcbA:
undetectable		 3cyxA-4lcbA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		3 / 3 SER A 303
GLY A 138
SER A 346
 None
CL  A 401 (-4.0A)
None
 0.68A 3loqA-4lcbA:
undetectable		 3loqA-4lcbA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		4 / 8 PHE A  96
ILE A  99
ALA A 145
VAL A 264
 None
 0.82A 3me6B-4lcbA:
undetectable		 3me6B-4lcbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		5 / 11 LEU A 133
ALA A 108
PRO A 265
VAL A 264
ILE A 262
 None
 1.21A 3oxxB-4lcbA:
undetectable		 3oxxB-4lcbA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		5 / 12 SER A 301
THR A 280
PHE A 336
ILE A 308
PHE A 276
 None
 1.46A 4c49B-4lcbA:
undetectable		 4c49B-4lcbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		4 / 8 ILE A 195
ILE A 131
ALA A 112
VAL A 148
 None
 0.79A 4jltA-4lcbA:
undetectable		 4jltA-4lcbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		5 / 12 LEU A 266
SER A 346
VAL A 347
PRO A 136
GLY A 242
 None
 1.32A 5f9zB-4lcbA:
undetectable		 5f9zB-4lcbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		5 / 12 LEU A 133
ALA A 108
PRO A 265
VAL A 264
ILE A 262
 None
 1.11A 5kqyA-4lcbA:
undetectable		 5kqyA-4lcbA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		5 / 12 LEU A 109
ILE A 131
GLY A 242
ILE A 195
LEU A 204
 None
 0.90A 5ycnA-4lcbA:
undetectable		 5ycnA-4lcbA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		5 / 12 LEU A 109
ILE A 131
GLY A 242
LEU A 223
LEU A 204
 None
 0.98A 5ycnA-4lcbA:
undetectable		 5ycnA-4lcbA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 4lcb CELL DIVISION
PROTEIN CDVC, VPS4
(Acidianus
hospitalis) 		5 / 12 ARG A 184
VAL A 238
ILE A 196
VAL A 176
ILE A 179
 None
 1.26A 6gsdA-4lcbA:
undetectable		 6gsdA-4lcbA:
13.08