SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lcc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
5 / 11 LEU C  63
ILE C 125
LEU C 123
PHE C  61
GLN C   2
None
1.43A 1tw4A-4lccC:
undetectable
1tw4A-4lccC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 PRO C 345
GLY C 347
GLY C 349
TYR C 351
None
0.73A 1usqB-4lccC:
undetectable
1usqB-4lccC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 PRO C 345
GLY C 347
GLY C 349
TYR C 351
None
0.72A 1usqC-4lccC:
undetectable
1usqC-4lccC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 PRO C 345
GLY C 347
GLY C 349
TYR C 351
None
0.74A 1usqD-4lccC:
undetectable
1usqD-4lccC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 PRO C 345
GLY C 347
GLY C 349
TYR C 351
None
0.74A 1usqE-4lccC:
undetectable
1usqE-4lccC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 7 LEU C 193
LEU C 190
SER C 151
TYR C 225
None
1.11A 2hc4A-4lccC:
undetectable
2hc4A-4lccC:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 PRO C 345
GLY C 347
GLY C 349
TYR C 351
None
0.70A 2jkjA-4lccC:
undetectable
2jkjA-4lccC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 PRO C 345
GLY C 347
GLY C 349
TYR C 351
None
0.71A 2jkjB-4lccC:
undetectable
2jkjB-4lccC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 PRO C 345
GLY C 347
GLY C 349
TYR C 351
None
0.71A 2jkjC-4lccC:
undetectable
2jkjC-4lccC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 PRO C 345
GLY C 347
GLY C 349
TYR C 351
None
0.75A 2jklB-4lccC:
undetectable
2jklB-4lccC:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 8 PHE C 318
HIS C 373
GLU C 372
ILE C 325
None
1.15A 4cx7A-4lccC:
undetectable
4cx7B-4lccC:
undetectable
4cx7A-4lccC:
20.34
4cx7B-4lccC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
3 / 3 PRO C 294
VAL C 371
HIS C 370
None
0.81A 4pevC-4lccC:
undetectable
4pevC-4lccC:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 7 LEU C  64
TYR C  28
PRO C 345
TYR C  10
None
0.90A 4z4fA-4lccC:
undetectable
4z4fA-4lccC:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 LEU C  64
TYR C  28
PRO C 345
TYR C  10
None
0.90A 4z4gA-4lccC:
undetectable
4z4gA-4lccC:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
4 / 6 GLY C 349
THR C 350
SER C 346
GLY C 317
None
0.92A 5k4pA-4lccC:
undetectable
5k4pA-4lccC:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
3 / 3 LYS C  57
TRP C  59
SER C  56
None
1.37A 5nwwA-4lccC:
undetectable
5nwwA-4lccC:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos
taurus)
5 / 12 SER C 137
ILE C 136
LEU C 167
PHE C  55
TYR C 120
1XL  C 401 (-2.9A)
None
None
None
1XL  C 401 (-3.9A)
1.08A 6a93A-4lccC:
undetectable
6a93A-4lccC:
21.10