SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		4 / 8 LEU A 198
ASP A 107
LEU A 108
LEU A 105
 None
 0.92A 1e7cA-4lcmA:
undetectable		 1e7cA-4lcmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 12 GLY A 342
LEU A  80
TYR A 279
PHE A 303
VAL A 282
 None
 0.99A 1fduC-4lcmA:
undetectable		 1fduC-4lcmA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 12 GLY A 343
LEU A  80
TYR A 279
PHE A 303
VAL A 282
 None
 1.07A 1fduC-4lcmA:
undetectable		 1fduC-4lcmA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 11 LEU A 286
ALA A  77
VAL A 299
LEU A  87
GLN A  88
 None
 1.25A 1kt6A-4lcmA:
undetectable		 1kt6A-4lcmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 9 VAL A  95
LEU A 207
TYR A 210
GLY A 196
ALA A 195
 None
 1.22A 1pxxB-4lcmA:
undetectable		 1pxxB-4lcmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 10 VAL A  95
LEU A 207
TYR A 210
GLY A 196
ALA A 195
 None
 1.21A 1pxxD-4lcmA:
undetectable		 1pxxD-4lcmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 11 LEU A 286
ALA A  77
VAL A 299
LEU A  87
GLN A  88
 None
 1.12A 1rlbF-4lcmA:
undetectable		 1rlbF-4lcmA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 12 MET A 224
LEU A  81
ILE A 369
PHE A 384
MET A  36
 None
 1.34A 1xmuB-4lcmA:
undetectable		 1xmuB-4lcmA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		4 / 4 GLY A 277
SER A 274
VAL A 282
LEU A 382
 None
 1.34A 1yajB-4lcmA:
undetectable		 1yajB-4lcmA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		4 / 6 LEU A  81
LEU A  80
LEU A 293
CYH A 216
 None
 0.82A 2ab2A-4lcmA:
undetectable		 2ab2A-4lcmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		4 / 5 LEU A  81
LEU A  80
LEU A 293
CYH A 216
 None
 0.84A 2ab2B-4lcmA:
undetectable		 2ab2B-4lcmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IT4_B_ACTB601_0
(ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN
ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ BETA CHAIN)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		4 / 4 ASN A 316
ARG A 337
LEU A 347
MET A 331
 None
 1.42A 3it4B-4lcmA:
0.0
3it4C-4lcmA:
0.0		 3it4B-4lcmA:
22.30
3it4C-4lcmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 10 ILE A 215
PHE A 384
ARG A  73
ALA A  75
LEU A  74
 None
 1.26A 3lw5B-4lcmA:
undetectable		 3lw5B-4lcmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 12 THR A 139
ASP A  98
LEU A 301
LEU A 341
GLY A 340
 None
 1.42A 3n58C-4lcmA:
undetectable		 3n58C-4lcmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 12 THR A 141
GLY A 143
GLY A 189
HIS A 140
ASP A 181
 None
 1.13A 3tkaA-4lcmA:
undetectable		 3tkaA-4lcmA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		4 / 8 PHE A 384
ARG A  73
ALA A  75
LEU A  74
 None
 1.03A 4rkuA-4lcmA:
undetectable
4rkuJ-4lcmA:
undetectable		 4rkuA-4lcmA:
20.43
4rkuJ-4lcmA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		4 / 5 LEU A  97
ASP A  98
LEU A 301
THR A 139
 None
 1.24A 4wozF-4lcmA:
undetectable
4wozH-4lcmA:
undetectable		 4wozF-4lcmA:
21.34
4wozH-4lcmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		4 / 7 PHE A 384
ARG A  73
ALA A  75
LEU A  74
 None
 1.03A 4xk8A-4lcmA:
undetectable		 4xk8A-4lcmA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		3 / 3 LEU A 149
TYR A 327
SER A 322
 None
 0.84A 5iktA-4lcmA:
undetectable		 5iktA-4lcmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		4 / 6 ARG A  73
GLY A 271
THR A  78
SER A  76
 None
 0.98A 5ny7A-4lcmA:
undetectable		 5ny7A-4lcmA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 12 LEU A 138
GLY A 340
ILE A 192
GLY A 343
GLY A 342
 None
 1.01A 5wyqB-4lcmA:
undetectable		 5wyqB-4lcmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4lcm TRANSESTERASE
(Aspergillus
terreus) 		5 / 12 SER A  76
LYS A  79
TYR A 146
PHE A 148
TYR A 188
 None
 0.75A 5zwrB-4lcmA:
37.1		 5zwrB-4lcmA:
26.47