SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		4 / 6 VAL A 292
VAL A 252
ILE A 325
ILE A 187
 None
 0.77A 1uwhA-4lctA:
2.1		 1uwhA-4lctA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		4 / 6 LEU A 322
ASP A 336
TYR A 335
LYS A 318
 None
 1.25A 2dpzA-4lctA:
undetectable		 2dpzA-4lctA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.23A 2hrcA-4lctA:
undetectable		 2hrcA-4lctA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.22A 2hrcB-4lctA:
undetectable		 2hrcB-4lctA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		5 / 11 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.25A 2po5B-4lctA:
undetectable		 2po5B-4lctA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.22A 2po7A-4lctA:
undetectable		 2po7A-4lctA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.21A 2po7B-4lctA:
undetectable		 2po7B-4lctA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		5 / 12 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.30A 2qd4A-4lctA:
undetectable		 2qd4A-4lctA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		4 / 5 LEU A 228
GLN A 191
THR A 193
HIS A 330
 None
 1.30A 2zj0C-4lctA:
undetectable		 2zj0C-4lctA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		4 / 5 LEU A 228
GLN A 191
THR A 193
HIS A 330
 None
 1.39A 3n58C-4lctA:
undetectable		 3n58C-4lctA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		5 / 12 TYR A 261
ASP A 329
GLU A 227
PHE A  54
HIS A  58
 None
 1.49A 4b9zA-4lctA:
undetectable		 4b9zA-4lctA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		5 / 12 ILE A 175
GLN A 204
LEU A 217
LEU A 209
ILE A 176
 None
 1.02A 4m2xC-4lctA:
undetectable		 4m2xC-4lctA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		3 / 3 SER A 186
MET A 189
ASP A 147
 None
 0.87A 4mm4B-4lctA:
undetectable		 4mm4B-4lctA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		4 / 5 ASN A 320
LEU A 321
SER A 316
LEU A 298
 None
 1.14A 4n09C-4lctA:
undetectable		 4n09C-4lctA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		4 / 5 TYR A 168
GLY A 141
ASP A 144
VAL A 185
 None
 1.11A 4nkvD-4lctA:
undetectable		 4nkvD-4lctA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		5 / 12 PHE A 302
ALA A 342
ARG A 339
TYR A 335
LEU A 314
 None
 1.15A 4qztC-4lctA:
undetectable		 4qztC-4lctA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		4 / 6 VAL A 252
VAL A 195
ILE A 163
PHE A 159
 None
 1.07A 5jw1B-4lctA:
undetectable		 5jw1B-4lctA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		4 / 6 ILE A 187
ALA A 220
LEU A 223
ILE A 253
 None
 0.82A 5mvmB-4lctA:
2.9
5mvmC-4lctA:
2.8		 5mvmB-4lctA:
16.05
5mvmC-4lctA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		3 / 3 GLU A 251
TYR A  43
ARG A  51
 None
 0.82A 5uunB-4lctA:
undetectable		 5uunB-4lctA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		3 / 3 ILE A 176
ASN A 214
CYH A 219
 None
 0.89A 6bp4A-4lctA:
undetectable		 6bp4A-4lctA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1
(Arabidopsis
thaliana) 		3 / 3 HIS A 326
ARG A  51
ILE A 325
 None
 0.76A 6fgdA-4lctA:
undetectable		 6fgdA-4lctA:
23.44