SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lcv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4lcv DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA
(Rattus
norvegicus) 		3 / 3 HIS A 242
ASP A 137
ASN A 141
 None
 0.83A 1wg8B-4lcvA:
undetectable		 1wg8B-4lcvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4lcv DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA
(Rattus
norvegicus) 		4 / 7 LYS A 221
ASN A 225
ARG A 181
HIS A 169
 None
None
BME  A 302 (-4.5A)
SO4  A 301 (-4.4A)
 1.19A 3frqB-4lcvA:
undetectable		 3frqB-4lcvA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4lcv DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA
(Rattus
norvegicus) 		4 / 6 LEU A 235
CYH A 145
HIS A 144
LEU A 134
 None
 1.18A 5hpuC-4lcvA:
undetectable
5hpuD-4lcvA:
undetectable		 5hpuC-4lcvA:
6.52
5hpuD-4lcvA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4lcv DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA
(Rattus
norvegicus) 		4 / 6 LEU A 238
CYH A 145
HIS A 144
LEU A 134
 None
 1.20A 5hpuC-4lcvA:
undetectable
5hpuD-4lcvA:
undetectable		 5hpuC-4lcvA:
6.52
5hpuD-4lcvA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lcv DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA
(Rattus
norvegicus) 		3 / 3 THR A 188
THR A 182
LEU A 130
 None
 0.70A 5m66D-4lcvA:
undetectable		 5m66D-4lcvA:
15.50