SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 ALA A  71
TYR A  67
ALA A  11
TYR A   9
 None
 1.05A 1xl6A-4lcyA:
3.3
1xl6B-4lcyA:
3.3		 1xl6A-4lcyA:
21.02
1xl6B-4lcyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 TRP A 167
GLU A  63
TYR A  59
 None
 1.02A 2a3aA-4lcyA:
undetectable		 2a3aA-4lcyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 ALA A  71
TYR A  67
ALA A  11
TYR A   9
 None
 1.00A 2wlkA-4lcyA:
undetectable
2wlkB-4lcyA:
undetectable		 2wlkA-4lcyA:
21.02
2wlkB-4lcyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
 None
 1.38A 2wuzA-4lcyA:
undetectable		 2wuzA-4lcyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
 None
 1.35A 2wuzB-4lcyA:
undetectable		 2wuzB-4lcyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 ASP A  74
SER A  77
TYR A  85
TYR A 123
 None
 1.35A 2xz5A-4lcyA:
undetectable
2xz5C-4lcyA:
undetectable		 2xz5A-4lcyA:
20.49
2xz5C-4lcyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 ARG A  48
VAL A  25
ARG A  35
ILE A  23
 None
 0.86A 2yfbA-4lcyA:
undetectable		 2yfbA-4lcyA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 ARG A  48
VAL A  25
ARG A  35
ILE A  23
 None
 0.90A 2yfbB-4lcyA:
undetectable		 2yfbB-4lcyA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.95A 2zm8A-4lcyA:
undetectable		 2zm8A-4lcyA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.01A 2zmaA-4lcyA:
undetectable		 2zmaA-4lcyA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 ASP A  74
SER A  77
TRP A 156
TYR A  99
 None
 1.18A 3havA-4lcyA:
undetectable		 3havA-4lcyA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		6 / 10 TYR A   9
TYR A  99
ASP A 114
TYR A 123
ILE A 124
TRP A 147
 None
 0.36A 3uprA-4lcyA:
34.2		 3uprA-4lcyA:
93.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		6 / 10 TYR A   9
TYR A  99
ASP A 114
TYR A 123
ILE A 124
TRP A 147
 None
 0.36A 3uprC-4lcyA:
34.2		 3uprC-4lcyA:
93.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		6 / 10 TYR A   9
TYR A  99
ASP A 114
TYR A 123
ILE A 124
TRP A 147
 None
 0.29A 3vriA-4lcyA:
34.5
3vriC-4lcyA:
undetectable		 3vriA-4lcyA:
93.43
3vriC-4lcyA:
4.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		6 / 10 TYR A  99
ASP A 114
SER A 116
TYR A 123
ILE A 124
TRP A 147
 None
 0.73A 3vriA-4lcyA:
34.5
3vriC-4lcyA:
undetectable		 3vriA-4lcyA:
93.43
3vriC-4lcyA:
4.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 ASP A 114
SER A 116
TYR A 123
ILE A 124
TRP A 147
 None
 0.78A 3vrjA-4lcyA:
34.5
3vrjC-4lcyA:
undetectable		 3vrjA-4lcyA:
93.43
3vrjC-4lcyA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		6 / 12 TYR A   9
TYR A  99
ASP A 114
TYR A 123
ILE A 124
TRP A 147
 None
 0.23A 3vrjA-4lcyA:
34.5
3vrjC-4lcyA:
undetectable		 3vrjA-4lcyA:
93.43
3vrjC-4lcyA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
None
NA  A 301 (-2.9A)
None
 1.39A 4lvcA-4lcyA:
undetectable		 4lvcA-4lcyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
None
NA  A 301 (-2.9A)
None
 1.38A 4lvcC-4lcyA:
undetectable		 4lvcC-4lcyA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 PRO A  47
ARG A  48
GLU A  53
 None
 0.59A 5j6hA-4lcyA:
33.5		 5j6hA-4lcyA:
76.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
None
NA  A 301 (-2.9A)
None
 1.39A 5m5kA-4lcyA:
undetectable		 5m5kA-4lcyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
None
NA  A 301 (-2.9A)
None
 1.41A 5m5kC-4lcyA:
undetectable		 5m5kC-4lcyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
None
NA  A 301 (-2.9A)
None
 1.37A 5m66B-4lcyA:
undetectable		 5m66B-4lcyA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 ASP A 114
SER A 116
TYR A 123
ILE A 124
TRP A 147
 None
 0.84A 5u98A-4lcyA:
34.8		 5u98A-4lcyA:
93.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		6 / 10 TYR A   9
TYR A  99
ASP A 114
TYR A 123
ILE A 124
TRP A 147
 None
 0.36A 5u98A-4lcyA:
34.8		 5u98A-4lcyA:
93.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		6 / 10 TYR A   9
TYR A  99
ASP A 114
TYR A 123
ILE A 124
TRP A 147
 None
 0.34A 5u98D-4lcyA:
34.6		 5u98D-4lcyA:
93.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 PHE A  36
ARG A  35
ALA A  71
GLN A  72
 None
 1.08A 6b89A-4lcyA:
undetectable		 6b89A-4lcyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
None
NA  A 301 (-2.9A)
None
 1.37A 6f3mB-4lcyA:
undetectable		 6f3mB-4lcyA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 ALA A 135
TYR A 123
GLN A 141
ILE A 142
 None
 1.36A 6f6sA-4lcyA:
undetectable
6f6sB-4lcyA:
0.0		 6f6sA-4lcyA:
15.85
6f6sB-4lcyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
None
NA  A 301 (-2.9A)
None
 1.40A 6gbnA-4lcyA:
undetectable		 6gbnA-4lcyA:
19.73