SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ld6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4ld6 PWWP
DOMAIN-CONTAINING
PROTEIN 2B
(Homo
sapiens) 		3 / 3 ARG A 554
VAL A 488
THR A 482
 None
 0.78A 2nmzA-4ld6A:
undetectable		 2nmzA-4ld6A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4ld6 PWWP
DOMAIN-CONTAINING
PROTEIN 2B
(Homo
sapiens) 		3 / 3 ARG A 554
VAL A 488
THR A 482
 None
 0.74A 3k4vD-4ld6A:
undetectable		 3k4vD-4ld6A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4ld6 PWWP
DOMAIN-CONTAINING
PROTEIN 2B
(Homo
sapiens) 		3 / 3 ARG A 554
VAL A 488
THR A 482
 None
 0.56A 3ndtA-4ld6A:
undetectable		 3ndtA-4ld6A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4ld6 PWWP
DOMAIN-CONTAINING
PROTEIN 2B
(Homo
sapiens) 		6 / 12 GLY A 496
ILE A 541
ARG A 554
VAL A 488
ILE A 511
THR A 482
 None
 1.01A 4q5mA-4ld6A:
undetectable		 4q5mA-4ld6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4ld6 PWWP
DOMAIN-CONTAINING
PROTEIN 2B
(Homo
sapiens) 		5 / 12 PHE A 547
LEU A 585
ALA A 571
PRO A 505
ARG A 564
 None
 1.30A 5ljbA-4ld6A:
undetectable		 5ljbA-4ld6A:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4ld6 PWWP
DOMAIN-CONTAINING
PROTEIN 2B
(Homo
sapiens) 		4 / 7 ILE A 498
PHE A 501
TRP A 504
TRP A 530
 GOL  A3001 (-4.7A)
GOL  A3001 (-3.2A)
GOL  A3001 (-3.6A)
GOL  A3001 (-3.4A)
 0.27A 5nr3A-4ld6A:
10.3		 5nr3A-4ld6A:
32.89