SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ld7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		4 / 6 TYR A  79
GLY A 107
PHE A 103
SER A 104
 None
 0.84A 2a3cA-4ld7A:
undetectable		 2a3cA-4ld7A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		4 / 6 TYR A  79
GLY A 107
PHE A 103
SER A 104
 None
 0.81A 2a3cB-4ld7A:
undetectable		 2a3cB-4ld7A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_2
(MINERALOCORTICOID
RECEPTOR)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		4 / 4 LEU A 337
TRP A 319
LEU A 358
MET A 368
 None
 1.34A 2oaxE-4ld7A:
0.0		 2oaxE-4ld7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		4 / 8 PHE A  78
LEU A 150
VAL A 149
LEU A 153
 None
 0.78A 2w98B-4ld7A:
undetectable		 2w98B-4ld7A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		4 / 5 GLU A  48
LEU A 437
HIS A  80
GLY A  37
 None
 1.20A 3pp1A-4ld7A:
undetectable		 3pp1A-4ld7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		4 / 7 ILE A 266
PHE A 103
MET A 110
GLY A 126
 None
 1.24A 3sj0X-4ld7A:
undetectable		 3sj0X-4ld7A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		4 / 5 LEU A  87
GLY A  88
PHE A 103
ASN A 142
 None
 1.15A 3uq6B-4ld7A:
undetectable		 3uq6B-4ld7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		3 / 3 GLU A 344
ILE A 206
ALA A 268
 None
 0.64A 4wnwB-4ld7A:
undetectable		 4wnwB-4ld7A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		3 / 3 THR A 404
THR A 406
PHE A 427
 None
 0.88A 5cxvA-4ld7A:
undetectable		 5cxvA-4ld7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		3 / 3 PRO A 243
LEU A 281
SER A 346
 None
 0.72A 5fsaB-4ld7A:
undetectable		 5fsaB-4ld7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		4 / 5 LEU A 360
LEU A 318
THR A 424
PRO A 354
 NA  A 502 (-4.5A)
None
None
None
 1.10A 6ew0F-4ld7A:
undetectable		 6ew0F-4ld7A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE
(Aspergillus
fischeri) 		4 / 6 LEU A 360
LEU A 318
THR A 424
PRO A 354
 NA  A 502 (-4.5A)
None
None
None
 1.10A 6ew0G-4ld7A:
undetectable		 6ew0G-4ld7A:
11.11