SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ld8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4ld8 MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		5 / 12 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.07A 1tw4A-4ld8A:
undetectable		 1tw4A-4ld8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4ld8 MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		3 / 3 ALA A  70
THR A 190
PHE A  73
 None
 0.58A 2c6nB-4ld8A:
undetectable		 2c6nB-4ld8A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4ld8 MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		5 / 12 ILE A 115
THR A 112
ASP A  56
ILE A 258
LEU A 288
 None
 1.15A 2jn3A-4ld8A:
undetectable		 2jn3A-4ld8A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4ld8 MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		5 / 12 ILE A 142
LEU A 150
GLY A 153
ARG A  52
ALA A 114
 None
 0.95A 2oc8A-4ld8A:
undetectable		 2oc8A-4ld8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4ld8 MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		4 / 6 ILE A 285
ARG A 204
ILE A 240
PHE A 247
 None
 0.99A 2q72A-4ld8A:
undetectable		 2q72A-4ld8A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ld8 MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		5 / 11 GLY A 206
ILE A 307
GLY A 220
ILE A 240
PHE A 247
 None
 1.12A 4qoiA-4ld8A:
undetectable
4qoiB-4ld8A:
undetectable		 4qoiA-4ld8A:
23.15
4qoiB-4ld8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 4ld8 MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		5 / 12 ILE A 285
LEU A 186
LEU A 218
THR A 272
LEU A 271
 None
 1.26A 6b54A-4ld8A:
undetectable		 6b54A-4ld8A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4ld8 MATRIX PROTEIN VP40
(Sudan
ebolavirus) 		4 / 6 ARG A 137
ALA A 118
LEU A 117
ALA A 113
 None
 1.21A 6fosB-4ld8A:
undetectable		 6fosB-4ld8A:
15.44