SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ldg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION
(Cryptosporidium
parvum) 		4 / 7 LEU A 141
THR A 140
HIS A 137
GLY A 218
 None
 0.93A 2ddwB-4ldgA:
undetectable		 2ddwB-4ldgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION
(Cryptosporidium
parvum) 		4 / 7 ILE A 267
TYR A 195
PHE A 259
ASP A 260
 None
 1.16A 2qebA-4ldgA:
undetectable		 2qebA-4ldgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION
(Cryptosporidium
parvum) 		4 / 5 LEU A 213
GLN A  21
LEU A  19
GLU A  18
 None
 1.14A 3h5gA-4ldgA:
undetectable
3h5gB-4ldgA:
undetectable		 3h5gA-4ldgA:
9.68
3h5gB-4ldgA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION
(Cryptosporidium
parvum) 		4 / 8 PHE A  34
VAL A 111
ILE A 112
ILE A 251
 None
 0.95A 5hw8H-4ldgA:
undetectable		 5hw8H-4ldgA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION
(Cryptosporidium
parvum) 		5 / 9 TYR A 193
LEU A 220
ASN A 222
HIS A 223
TYR A 261
 None
 1.01A 5tegA-4ldgA:
15.8
5tegD-4ldgA:
undetectable		 5tegA-4ldgA:
30.58
5tegD-4ldgA:
5.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION
(Cryptosporidium
parvum) 		5 / 10 GLY A 149
TYR A 193
LEU A 220
ASN A 222
HIS A 223
 None
 0.92A 5tegB-4ldgA:
15.9
5tegE-4ldgA:
undetectable		 5tegB-4ldgA:
30.58
5tegE-4ldgA:
5.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION
(Cryptosporidium
parvum) 		5 / 10 TYR A 193
LEU A 220
ASN A 222
HIS A 223
TYR A 261
 None
 1.02A 5tegB-4ldgA:
15.9
5tegE-4ldgA:
undetectable		 5tegB-4ldgA:
30.58
5tegE-4ldgA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION
(Cryptosporidium
parvum) 		5 / 11 ALA A 199
ASP A 263
VAL A 164
ILE A 230
ILE A 221
 None
 1.27A 5y80A-4ldgA:
undetectable		 5y80A-4ldgA:
12.55