SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ldp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 12 ASN A 230
GLY A 332
THR A 339
ALA A 340
VAL A 345
 None
 1.06A 1jg4A-4ldpA:
2.9		 1jg4A-4ldpA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 5 ALA A 204
TYR A 221
ILE A 222
ASP A 155
 None
 1.17A 1upfC-4ldpA:
undetectable		 1upfC-4ldpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 10 LEU A 151
GLN A 337
LEU A 363
TYR A 221
THR A 205
 None
 1.47A 1zucA-4ldpA:
undetectable		 1zucA-4ldpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		6 / 12 ALA A 361
GLY A 370
ASN A 399
LEU A 371
GLY A 332
ASP A 366
 None
 1.33A 2f8lA-4ldpA:
3.8		 2f8lA-4ldpA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 12 LEU A 151
ALA A 153
LEU A 215
LEU A 363
THR A 341
 None
 1.46A 2oaxF-4ldpA:
undetectable		 2oaxF-4ldpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 12 GLY A 144
ALA A 145
ASP A 125
THR A   6
VAL A 127
 None
 0.89A 3el4A-4ldpA:
undetectable		 3el4A-4ldpA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 5 LEU A   8
LEU A  59
MET A  39
THR A 255
 None
 1.40A 4do3A-4ldpA:
2.0		 4do3A-4ldpA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		3 / 3 ASP A 114
LEU A 115
PHE A 118
 None
 0.67A 4pthA-4ldpA:
undetectable		 4pthA-4ldpA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 12 PRO A   9
ALA A  10
ARG A 149
VAL A 133
HIS A 105
 None
 1.11A 4rvdA-4ldpA:
4.5		 4rvdA-4ldpA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 12 THR A 294
THR A 336
GLY A 231
PRO A 232
ALA A 233
 None
 1.23A 4ypmA-4ldpA:
undetectable		 4ypmA-4ldpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		3 / 3 TRP A 129
ARG A 149
LEU A 184
 None
 0.91A 5dbyA-4ldpA:
undetectable		 5dbyA-4ldpA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 11 GLN A 347
VAL A 248
THR A 251
PRO A 246
LEU A 391
 None
 1.36A 5jh7B-4ldpA:
4.5		 5jh7B-4ldpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		3 / 3 VAL A  53
ARG A 149
PRO A 137
 None
 0.67A 5koxA-4ldpA:
undetectable		 5koxA-4ldpA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		5 / 11 GLU A 290
GLY A 283
ALA A 285
ILE A 329
VAL A 383
 None
 1.05A 5yk2A-4ldpA:
undetectable		 5yk2A-4ldpA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4ldp NDP-FOROSAMYLTRANSFE
RASE
(Saccharopolyspor
a
spinosa) 		4 / 6 VAL A  53
LEU A 184
ARG A 149
PRO A 137
 None
 1.33A 6brdB-4ldpA:
undetectable		 6brdB-4ldpA:
11.42