SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ldq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 12 SER A 187
VAL A 184
GLY A 183
TYR A 178
GLY A 147
 None
 1.10A 1fduC-4ldqA:
4.6		 1fduC-4ldqA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		4 / 7 THR A 170
LEU A 211
GLY A 208
LEU A 216
 None
 0.97A 1gtiE-4ldqA:
undetectable		 1gtiE-4ldqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 12 GLY A 144
GLY A 147
ALA A 279
TYR A 178
SER A 187
 None
 0.99A 1ri4A-4ldqA:
6.0		 1ri4A-4ldqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 11 VAL A 184
GLY A 183
ALA A 148
LEU A 151
SER A 241
 None
 1.24A 2bxgA-4ldqA:
2.7		 2bxgA-4ldqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		4 / 6 HIS A 167
ASN A 258
THR A 202
PRO A 204
 None
 1.17A 2ez7A-4ldqA:
undetectable		 2ez7A-4ldqA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		4 / 8 LEU A  53
LEU A  57
ALA A  99
LEU A 103
 None
 0.55A 2vcvP-4ldqA:
undetectable		 2vcvP-4ldqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		4 / 7 ILE A  51
SER A  32
GLU A  38
VAL A  30
 None
 0.88A 3ua5B-4ldqA:
1.7		 3ua5B-4ldqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		4 / 4 ASN A 169
ALA A 174
GLY A 171
THR A 180
 None
 1.04A 4bboC-4ldqA:
undetectable		 4bboC-4ldqA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 12 GLU A 219
GLY A 171
PHE A 214
TYR A  27
TYR A 218
 None
 1.32A 4ffwB-4ldqA:
undetectable		 4ffwB-4ldqA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		6 / 12 VAL A 164
ILE A 143
GLY A 179
ILE A 221
SER A 187
LEU A 194
 None
 1.22A 4iv0A-4ldqA:
4.7		 4iv0A-4ldqA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		4 / 8 ASP A 248
GLU A 298
MET A  96
VAL A  94
 None
 1.03A 4lnwA-4ldqA:
undetectable		 4lnwA-4ldqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		6 / 12 VAL A 164
ILE A 143
GLY A 179
ILE A 221
SER A 187
LEU A 194
 None
 1.21A 4mwzB-4ldqA:
4.5		 4mwzB-4ldqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 9 ILE A 143
VAL A 184
ALA A 181
THR A 166
ALA A 242
 None
 1.31A 4oqrA-4ldqA:
undetectable		 4oqrA-4ldqA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 9 VAL A 155
ILE A 143
ALA A 181
THR A 166
ALA A 242
 None
 1.14A 4oqrA-4ldqA:
undetectable		 4oqrA-4ldqA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 12 ALA A 172
GLY A 171
THR A 170
ALA A 174
THR A 175
 None
 1.20A 4qvyV-4ldqA:
undetectable
4qvyW-4ldqA:
undetectable		 4qvyV-4ldqA:
20.75
4qvyW-4ldqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 11 ALA A 172
GLY A 171
THR A 170
ALA A 174
THR A 175
 None
 1.21A 4qw0H-4ldqA:
undetectable
4qw0I-4ldqA:
undetectable		 4qw0H-4ldqA:
20.75
4qw0I-4ldqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 11 ALA A 172
GLY A 171
THR A 170
ALA A 174
THR A 175
 None
 1.20A 4qw0V-4ldqA:
undetectable
4qw0W-4ldqA:
undetectable		 4qw0V-4ldqA:
20.75
4qw0W-4ldqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 11 ALA A 172
GLY A 171
THR A 170
ALA A 174
THR A 175
 None
 1.20A 5bxnH-4ldqA:
undetectable
5bxnI-4ldqA:
undetectable		 5bxnH-4ldqA:
19.73
5bxnI-4ldqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		4 / 6 HIS A 196
LEU A 194
CYH A 199
LEU A 216
 None
 0.96A 5hrqD-4ldqA:
undetectable
5hrqG-4ldqA:
undetectable
5hrqH-4ldqA:
undetectable		 5hrqD-4ldqA:
6.54
5hrqG-4ldqA:
5.82
5hrqH-4ldqA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 12 ALA A 172
GLY A 171
THR A 170
ALA A 174
THR A 175
 None
 1.22A 5l5fH-4ldqA:
undetectable
5l5fI-4ldqA:
undetectable		 5l5fH-4ldqA:
20.75
5l5fI-4ldqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 12 ALA A 172
GLY A 171
THR A 170
ALA A 174
THR A 175
 None
 1.22A 5l5fV-4ldqA:
undetectable
5l5fW-4ldqA:
undetectable		 5l5fV-4ldqA:
20.75
5l5fW-4ldqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 12 ALA A 172
GLY A 171
THR A 170
ALA A 174
THR A 175
 None
 1.22A 5l66H-4ldqA:
undetectable
5l66I-4ldqA:
undetectable		 5l66H-4ldqA:
20.75
5l66I-4ldqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		5 / 12 GLN A 207
ALA A 172
GLY A 171
THR A 170
ALA A 174
 None
 1.28A 5l66H-4ldqA:
undetectable
5l66I-4ldqA:
undetectable		 5l66H-4ldqA:
20.75
5l66I-4ldqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens) 		4 / 8 VAL A 250
THR A 170
ALA A 181
THR A 180
 None
 0.77A 5og9A-4ldqA:
1.5		 5og9A-4ldqA:
21.69