SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 8 GLY A 284
GLY A  28
SER A 263
GLY A  24
 None
 0.72A 1d0vA-4ldsA:
undetectable		 1d0vA-4ldsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 LEU A 307
LEU A 306
GLY A 309
MET A 314
ALA A 414
 None
 1.13A 1gs4A-4ldsA:
undetectable		 1gs4A-4ldsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 8 GLY A 284
GLY A  28
SER A 263
GLY A  24
 None
 0.74A 1jhaA-4ldsA:
undetectable		 1jhaA-4ldsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 GLY A  20
GLY A 143
LEU A  17
VAL A 109
ILE A 105
 None
 0.91A 1zq9B-4ldsA:
undetectable		 1zq9B-4ldsA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 ILE A 248
ALA A 247
SER A 376
ILE A  56
PHE A 252
 None
 1.08A 2h77A-4ldsA:
undetectable		 2h77A-4ldsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 8 LEU A 422
ARG A 303
SER A 376
VAL A 358
 None
 1.07A 2qd2A-4ldsA:
undetectable		 2qd2A-4ldsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 7 TYR A 261
SER A 264
ILE A 337
SER A 395
 None
 1.09A 2xz5A-4ldsA:
undetectable
2xz5B-4ldsA:
undetectable		 2xz5A-4ldsA:
20.25
2xz5B-4ldsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 8 TYR A 261
SER A 264
ILE A 337
SER A 395
 None
 1.09A 2xz5B-4ldsA:
undetectable
2xz5E-4ldsA:
undetectable		 2xz5B-4ldsA:
20.25
2xz5E-4ldsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 THR A 373
GLN A 250
ALA A 247
ASN A 381
ILE A 382
 None
 1.18A 3ddyA-4ldsA:
undetectable		 3ddyA-4ldsA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 ILE A 315
GLY A 313
ILE A 350
ALA A 316
LEU A 343
 None
 0.82A 3fpjA-4ldsA:
undetectable		 3fpjA-4ldsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		3 / 3 ARG A 367
THR A 373
THR A 126
 None
 0.67A 3k2hB-4ldsA:
undetectable		 3k2hB-4ldsA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 GLY A  63
GLY A 111
GLY A  70
LEU A  77
ILE A  78
 None
 0.95A 3ku1G-4ldsA:
undetectable		 3ku1G-4ldsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 8 SER A 262
ASN A 256
ILE A 144
SER A  27
GLY A  24
 None
 1.45A 3lslA-4ldsA:
undetectable
3lslD-4ldsA:
undetectable		 3lslA-4ldsA:
20.36
3lslD-4ldsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 LEU A 356
LEU A 360
LEU A 380
ILE A 253
GLY A 254
 None
 1.02A 3q95B-4ldsA:
undetectable		 3q95B-4ldsA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 ILE A  46
GLY A  45
ILE A  26
VAL A  25
LEU A  52
 None
 1.18A 4a81A-4ldsA:
undetectable		 4a81A-4ldsA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 8 ASN A 151
ALA A  29
SER A  27
ARG A 102
 None
 1.18A 4ijiF-4ldsA:
undetectable		 4ijiF-4ldsA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 7 LEU A 422
ARG A 303
SER A 376
VAL A 358
 None
 1.17A 4klrA-4ldsA:
undetectable		 4klrA-4ldsA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 10 PRO A 125
MET A 201
LYS A 212
GLU A 216
LEU A 189
 None
 1.44A 4la0A-4ldsA:
undetectable		 4la0A-4ldsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 ILE A 248
ALA A 247
SER A 376
ILE A  56
PHE A 252
 None
 1.12A 4lnwA-4ldsA:
undetectable		 4lnwA-4ldsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 ILE A 248
ALA A 247
SER A 376
ILE A  56
PHE A 252
 None
 1.13A 4lnxA-4ldsA:
undetectable		 4lnxA-4ldsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 GLY A  58
GLY A 106
ILE A  56
MET A  51
ILE A  78
 None
 1.13A 4qtuB-4ldsA:
undetectable		 4qtuB-4ldsA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 GLY A  58
GLY A 106
ILE A  56
MET A  51
ILE A  78
 None
 1.09A 4qtuD-4ldsA:
undetectable		 4qtuD-4ldsA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 7 MET A 366
GLU A 216
GLU A 213
ARG A 186
 None
 1.43A 4r87J-4ldsA:
undetectable
4r87L-4ldsA:
undetectable		 4r87J-4ldsA:
16.81
4r87L-4ldsA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 8 GLU A 122
VAL A 118
GLY A  70
LEU A  74
 None
 0.71A 5sxqA-4ldsA:
undetectable		 5sxqA-4ldsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 8 GLU A 122
VAL A 118
GLY A  70
LEU A  74
 None
 0.71A 5sxqB-4ldsA:
undetectable		 5sxqB-4ldsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		4 / 8 GLU A 122
VAL A 118
GLY A  70
LEU A  74
 None
 0.72A 5syjA-4ldsA:
0.9		 5syjA-4ldsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 12 TRP A 160
ALA A 108
GLY A 101
GLY A  85
SER A  92
 None
 1.18A 6clxA-4ldsA:
undetectable		 6clxA-4ldsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB
(Staphylococcus
epidermidis) 		5 / 10 THR A 141
GLY A 349
GLY A 353
GLN A 137
ASN A 287
 None
 1.02A 6nqaK-4ldsA:
undetectable		 6nqaK-4ldsA:
21.62