SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4le1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_A_CTXA11_1 (CES1 PROTEIN)	4le1	TRANSCRIPTIONAL REGULATORY PROTEIN DESR (Bacillus subtilis)	4 / 8	MET A 53 LEU A 17 GLY A 18 LEU A 109	None	0.87A	1ya4A-4le1A: 3.7	1ya4A-4le1A: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD3_A_CHDA501_0 (FERROCHELATASE)	4le1	TRANSCRIPTIONAL REGULATORY PROTEIN DESR (Bacillus subtilis)	5 / 11	LEU A 21 LEU A 109 ILE A 4 THR A 80 VAL A 116	None	1.33A	2qd3A-4le1A: 4.6	2qd3A-4le1A: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZV_A_SAMA1474_0 (WBDD)	4le1	TRANSCRIPTIONAL REGULATORY PROTEIN DESR (Bacillus subtilis)	5 / 12	GLY A 18 ALA A 16 ILE A 4 LEU A 23 ILE A 113	None	0.98A	4azvA-4le1A: 3.3	4azvA-4le1A: 14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GC9_A_ACTA402_0 (DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL)	4le1	TRANSCRIPTIONAL REGULATORY PROTEIN DESR (Bacillus subtilis)	3 / 3	LYS A 97 TYR A 123 ARG A 121	None	1.45A	4gc9A-4le1A: undetectable	4gc9A-4le1A: 19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UW0_A_SAMA1506_0 (WBDD)	4le1	TRANSCRIPTIONAL REGULATORY PROTEIN DESR (Bacillus subtilis)	5 / 12	GLY A 18 ALA A 16 ILE A 4 LEU A 23 ILE A 113	None	1.12A	4uw0A-4le1A: 3.0	4uw0A-4le1A: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y03_A_SALA801_1 (PROTEIN POLYBROMO-1)	4le1	TRANSCRIPTIONAL REGULATORY PROTEIN DESR (Bacillus subtilis)	4 / 7	ILE A 4 LEU A 17 ALA A 110 ILE A 113	None	0.84A	4y03A-4le1A: undetectable	4y03A-4le1A: 23.53

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YA4_A_CTXA11_1","CES1 PROTEIN","4le1","TRANSCRIPTIONAL REGULATORY PROTEIN DESR","Bacillus subtilis",4,"MET A  53;LEU A  17;GLY A  18;LEU A 109","None","0.87A","1ya4A-4le1A:3.7","1ya4A-4le1A:13.94"],["2QD3_A_CHDA501_0","FERROCHELATASE","4le1","TRANSCRIPTIONAL REGULATORY PROTEIN DESR","Bacillus subtilis",5,"LEU A  21;LEU A 109;ILE A   4;THR A  80;VAL A 116","None","1.33A","2qd3A-4le1A:4.6","2qd3A-4le1A:18.28"],["4AZV_A_SAMA1474_0","WBDD","4le1","TRANSCRIPTIONAL REGULATORY PROTEIN DESR","Bacillus subtilis",5,"GLY A  18;ALA A  16;ILE A   4;LEU A  23;ILE A 113","None","0.98A","4azvA-4le1A:3.3","4azvA-4le1A:14.54"],["4GC9_A_ACTA402_0","DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL","4le1","TRANSCRIPTIONAL REGULATORY PROTEIN DESR","Bacillus subtilis",3,"LYS A  97;TYR A 123;ARG A 121","None","1.45A","4gc9A-4le1A:undetectable","4gc9A-4le1A:19.30"],["4UW0_A_SAMA1506_0","WBDD","4le1","TRANSCRIPTIONAL REGULATORY PROTEIN DESR","Bacillus subtilis",5,"GLY A  18;ALA A  16;ILE A   4;LEU A  23;ILE A 113","None","1.12A","4uw0A-4le1A:3.0","4uw0A-4le1A:14.52"],["4Y03_A_SALA801_1","PROTEIN POLYBROMO-1","4le1","TRANSCRIPTIONAL REGULATORY PROTEIN DESR","Bacillus subtilis",4,"ILE A   4;LEU A  17;ALA A 110;ILE A 113","None","0.84A","4y03A-4le1A:undetectable","4y03A-4le1A:23.53"]]