SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4le6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 8 HIS A 139
HIS A 230
LEU A 250
HIS A 294
 ZN  A 405 (-3.3A)
None
None
ZN  A 406 (-3.2A)
 1.01A 1azmA-4le6A:
undetectable		 1azmA-4le6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		3 / 3 TRP A 312
VAL A 313
PRO A 314
 None
 0.72A 1rg1A-4le6A:
undetectable		 1rg1A-4le6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		3 / 3 TRP A 312
VAL A 313
PRO A 314
 None
 0.72A 1rh0A-4le6A:
undetectable		 1rh0A-4le6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 7 PHE A 297
ASN A  90
TYR A  92
VAL A  47
 None
 1.40A 1wu8A-4le6A:
undetectable
1wu8C-4le6A:
undetectable		 1wu8A-4le6A:
21.56
1wu8C-4le6A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 12 THR A 138
LEU A 234
ILE A  94
VAL A  47
ALA A 293
 None
 1.30A 2g72B-4le6A:
undetectable		 2g72B-4le6A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 11 ASP A 143
HIS A 144
ASP A 247
LEU A 250
PHE A 263
 ZN  A 406 (-2.6A)
ZN  A 406 (-3.2A)
ZN  A 406 ( 2.3A)
None
None
 1.17A 2q0jB-4le6A:
12.2		 2q0jB-4le6A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 11 ASP A 143
HIS A 144
HIS A 226
ASP A 247
HIS A 294
 ZN  A 406 (-2.6A)
ZN  A 406 (-3.2A)
ZN  A 405 (-3.1A)
ZN  A 406 ( 2.3A)
ZN  A 406 (-3.2A)
 0.58A 2q0jB-4le6A:
12.2		 2q0jB-4le6A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 11 ASP A 143
HIS A 144
HIS A 226
ASP A 247
PHE A 263
 ZN  A 406 (-2.6A)
ZN  A 406 (-3.2A)
ZN  A 405 (-3.1A)
ZN  A 406 ( 2.3A)
None
 1.04A 2q0jB-4le6A:
12.2		 2q0jB-4le6A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 12 THR A  96
ILE A 103
THR A 105
VAL A 118
LEU A  50
 None
None
None
GOL  A 401 (-3.8A)
None
 1.26A 3a51B-4le6A:
undetectable		 3a51B-4le6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 10 HIS A 139
HIS A 141
ASP A 143
HIS A 226
HIS A 294
 ZN  A 405 (-3.3A)
ZN  A 405 ( 3.1A)
ZN  A 406 (-2.6A)
ZN  A 405 (-3.1A)
ZN  A 406 (-3.2A)
 0.70A 4c1dB-4le6A:
13.2		 4c1dB-4le6A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		6 / 11 VAL A  55
HIS A 139
HIS A 141
ASP A 143
HIS A 226
HIS A 294
 EDO  A 407 ( 4.8A)
ZN  A 405 (-3.3A)
ZN  A 405 ( 3.1A)
ZN  A 406 (-2.6A)
ZN  A 405 (-3.1A)
ZN  A 406 (-3.2A)
 1.34A 4c1fA-4le6A:
4.1
4c1fB-4le6A:
3.1		 4c1fA-4le6A:
21.74
4c1fB-4le6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 9 HIS A 139
HIS A 141
ASP A 143
HIS A 226
HIS A 294
 ZN  A 405 (-3.3A)
ZN  A 405 ( 3.1A)
ZN  A 406 (-2.6A)
ZN  A 405 (-3.1A)
ZN  A 406 (-3.2A)
 0.68A 4c1hA-4le6A:
3.8		 4c1hA-4le6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 10 THR A 231
THR A 134
LEU A 220
LEU A 214
VAL A 101
 EDO  A 403 (-3.2A)
None
EDO  A 403 ( 4.8A)
None
None
 1.18A 4c9nB-4le6A:
undetectable		 4c9nB-4le6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 9 VAL A  55
HIS A 141
ASP A 143
HIS A 226
HIS A 294
 EDO  A 407 ( 4.8A)
ZN  A 405 ( 3.1A)
ZN  A 406 (-2.6A)
ZN  A 405 (-3.1A)
ZN  A 406 (-3.2A)
 0.89A 4exsA-4le6A:
13.0		 4exsA-4le6A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 8 VAL A  55
HIS A 141
ASP A 143
HIS A 226
HIS A 294
 EDO  A 407 ( 4.8A)
ZN  A 405 ( 3.1A)
ZN  A 406 (-2.6A)
ZN  A 405 (-3.1A)
ZN  A 406 (-3.2A)
 0.84A 4exsB-4le6A:
3.4		 4exsB-4le6A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 6 PHE A 263
ASP A 247
HIS A 294
THR A  87
 None
ZN  A 406 ( 2.3A)
ZN  A 406 (-3.2A)
None
 1.28A 4paeA-4le6A:
undetectable		 4paeA-4le6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		3 / 3 PRO A  58
LEU A  57
HIS A 141
 None
None
ZN  A 405 ( 3.1A)
 0.68A 4pevA-4le6A:
undetectable		 4pevA-4le6A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		3 / 3 ASP A 266
LYS A  63
LEU A  70
 None
 0.94A 4ptjA-4le6A:
undetectable		 4ptjA-4le6A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 12 GLY A 116
LEU A 115
ALA A  91
ASP A 104
PHE A 111
 GOL  A 401 (-3.6A)
None
None
None
GOL  A 402 (-3.8A)
 1.05A 4wnwB-4le6A:
undetectable		 4wnwB-4le6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 8 HIS A 141
ASP A 143
HIS A 226
HIS A 294
 ZN  A 405 ( 3.1A)
ZN  A 406 (-2.6A)
ZN  A 405 (-3.1A)
ZN  A 406 (-3.2A)
 0.73A 5a5zA-4le6A:
12.9		 5a5zA-4le6A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 8 VAL A  55
HIS A 141
ASP A 143
HIS A 226
 EDO  A 407 ( 4.8A)
ZN  A 405 ( 3.1A)
ZN  A 406 (-2.6A)
ZN  A 405 (-3.1A)
 0.76A 5a5zA-4le6A:
12.9		 5a5zA-4le6A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		6 / 11 HIS A 139
HIS A 141
ASP A 143
HIS A 144
HIS A 226
HIS A 294
 ZN  A 405 (-3.3A)
ZN  A 405 ( 3.1A)
ZN  A 406 (-2.6A)
ZN  A 406 (-3.2A)
ZN  A 405 (-3.1A)
ZN  A 406 (-3.2A)
 0.42A 5ayaA-4le6A:
12.9		 5ayaA-4le6A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 12 LEU A 242
PHE A 235
LEU A 100
ALA A  91
LEU A 122
 None
 1.39A 5ienA-4le6A:
undetectable		 5ienA-4le6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 5 LEU A  93
TYR A  37
LEU A 122
TYR A 127
 None
 1.41A 5ki6A-4le6A:
undetectable		 5ki6A-4le6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 8 HIS A 294
SER A 223
HIS A 226
HIS A 139
 ZN  A 406 (-3.2A)
EDO  A 403 ( 4.7A)
ZN  A 405 (-3.1A)
ZN  A 405 (-3.3A)
 0.92A 5m8rB-4le6A:
undetectable		 5m8rB-4le6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 8 HIS A 294
SER A 223
HIS A 226
HIS A 139
 ZN  A 406 (-3.2A)
EDO  A 403 ( 4.7A)
ZN  A 405 (-3.1A)
ZN  A 405 (-3.3A)
 0.92A 5m8rD-4le6A:
undetectable		 5m8rD-4le6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 6 ASP A 247
HIS A 226
HIS A 139
HIS A 294
 ZN  A 406 ( 2.3A)
ZN  A 405 (-3.1A)
ZN  A 405 (-3.3A)
ZN  A 406 (-3.2A)
 0.92A 5ncdA-4le6A:
undetectable
5ncdD-4le6A:
undetectable		 5ncdA-4le6A:
22.55
5ncdD-4le6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 6 ASP A 247
HIS A 226
HIS A 139
HIS A 294
 ZN  A 406 ( 2.3A)
ZN  A 405 (-3.1A)
ZN  A 405 (-3.3A)
ZN  A 406 (-3.2A)
 0.90A 5ncdB-4le6A:
undetectable
5ncdC-4le6A:
undetectable		 5ncdB-4le6A:
22.55
5ncdC-4le6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 8 ASP A 247
HIS A 226
HIS A 139
HIS A 294
 ZN  A 406 ( 2.3A)
ZN  A 405 (-3.1A)
ZN  A 405 (-3.3A)
ZN  A 406 (-3.2A)
 0.82A 5nekD-4le6A:
undetectable		 5nekD-4le6A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		5 / 10 HIS A 139
HIS A 141
HIS A 144
HIS A 226
ASP A 247
 ZN  A 405 (-3.3A)
ZN  A 405 ( 3.1A)
ZN  A 406 (-3.2A)
ZN  A 405 (-3.1A)
ZN  A 406 ( 2.3A)
 0.34A 5nzwA-4le6A:
2.4		 5nzwA-4le6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 4le6 ORGANOPHOSPHORUS
HYDROLASE
(Pseudomonas
pseudoalcaligene
s) 		4 / 8 HIS A 141
ASP A 143
HIS A 226
HIS A 294
 ZN  A 405 ( 3.1A)
ZN  A 406 (-2.6A)
ZN  A 405 (-3.1A)
ZN  A 406 (-3.2A)
 0.70A 5zj8A-4le6A:
13.5		 5zj8A-4le6A:
23.43