SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4le7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 248
TYR A  91
PHE A 103
ASP A 105
 None
EDO  A 303 (-4.7A)
None
None
 1.13A 2qebA-4le7A:
undetectable		 2qebA-4le7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 248
TYR A  91
PHE A 103
ASP A 105
 None
EDO  A 303 (-4.7A)
None
None
 1.08A 2qebB-4le7A:
undetectable		 2qebB-4le7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 7 GLN A   9
SER A   4
LEU A  36
ILE A  11
 EDO  A 302 ( 3.7A)
EDO  A 302 (-2.4A)
None
None
 1.08A 3ln1C-4le7A:
undetectable		 3ln1C-4le7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 8 SER A   3
ILE A 248
PRO A 127
ILE A 125
 None
 0.88A 4dtaB-4le7A:
undetectable		 4dtaB-4le7A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 8 ASN A  93
PHE A 100
ILE A  17
ALA A   6
 None
None
None
EDO  A 301 ( 4.1A)
 1.02A 4eyzA-4le7A:
undetectable		 4eyzA-4le7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 8 ASN A  93
PHE A 100
ILE A  17
ALA A   6
 None
None
None
EDO  A 301 ( 4.1A)
 1.02A 4eyzB-4le7A:
undetectable		 4eyzB-4le7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 6 GLY A  22
PRO A  20
ASN A  21
GLY A 241
 None
EDO  A 305 ( 4.5A)
None
None
 0.91A 4fjpA-4le7A:
undetectable		 4fjpA-4le7A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		3 / 3 VAL A  50
LEU A   5
MET A  58
 EDO  A 318 (-4.2A)
None
None
 0.71A 5ikrA-4le7A:
undetectable		 5ikrA-4le7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		3 / 3 VAL A  50
LEU A  92
MET A  58
 EDO  A 318 (-4.2A)
None
None
 0.78A 5ikrA-4le7A:
undetectable		 5ikrA-4le7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 137
THR A 136
THR A 167
LEU A 213
 None
 1.44A 5v96A-4le7A:
undetectable		 5v96A-4le7A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 137
THR A 136
THR A 167
LEU A 213
 None
 1.44A 5v96B-4le7A:
undetectable		 5v96B-4le7A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 137
THR A 136
THR A 167
LEU A 213
 None
 1.44A 5v96C-4le7A:
undetectable		 5v96C-4le7A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 137
THR A 136
THR A 167
LEU A 213
 None
 1.43A 5v96D-4le7A:
undetectable		 5v96D-4le7A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 6 GLN A 161
VAL A 163
ALA A 166
THR A 167
 None
 1.01A 6cduB-4le7A:
undetectable
6cduC-4le7A:
undetectable		 6cduB-4le7A:
22.90
6cduC-4le7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		5 / 12 TRP A 251
SER A 250
ILE A 248
VAL A 235
LEU A  26
 None
EDO  A 305 (-3.9A)
None
None
None
 1.34A 6djzB-4le7A:
undetectable		 6djzB-4le7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4le7 PYOCIN L1
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 185
THR A 169
THR A 195
LEU A 213
 None
 1.10A 6f3mD-4le7A:
undetectable		 6f3mD-4le7A:
18.44