SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 10 LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
 None
 1.43A 1fk9A-4lecA:
undetectable		 1fk9A-4lecA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 9 LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
 None
 1.32A 1ikvA-4lecA:
undetectable		 1ikvA-4lecA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 10 LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
 None
 1.42A 1ikwA-4lecA:
undetectable		 1ikwA-4lecA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 12 ALA A 143
ILE A 206
ILE A 140
ALA A  83
VAL A  79
 SAH  A 301 (-3.6A)
None
None
None
None
 0.87A 2b7zA-4lecA:
undetectable		 2b7zA-4lecA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 12 ALA A  74
ASP A  94
VAL A 120
ILE A  33
ILE A  92
 None
SAH  A 301 (-2.9A)
None
None
None
 0.93A 2z54B-4lecA:
undetectable		 2z54B-4lecA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 10 ALA A  83
LEU A 141
VAL A  62
ALA A 172
ILE A 206
 None
 1.13A 3fl9F-4lecA:
undetectable		 3fl9F-4lecA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 9 LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
 None
 1.49A 3lp0A-4lecA:
undetectable		 3lp0A-4lecA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 10 LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
 None
 1.46A 3lp1A-4lecA:
undetectable		 3lp1A-4lecA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 12 GLU A  71
GLY A  73
GLY A  75
THR A  76
LEU A  78
 SAH  A 301 ( 4.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.3A)
None
None
 0.62A 3sglA-4lecA:
9.4		 3sglA-4lecA:
14.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		6 / 12 TRP A  47
ALA A  49
GLY A  73
TRP A 125
ALA A 143
TYR A 147
 SAH  A 301 (-4.6A)
SAH  A 301 ( 4.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
 1.41A 4lg1A-4lecA:
25.1		 4lg1A-4lecA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		8 / 12 TRP A  47
ALA A  50
GLY A  73
GLY A  75
ASP A  94
TRP A 125
ALA A 143
TYR A 147
 SAH  A 301 (-4.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
 0.32A 4lg1A-4lecA:
25.1		 4lg1A-4lecA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		6 / 12 TRP A  47
ALA A  49
GLY A  73
TRP A 125
ALA A 143
TYR A 147
 SAH  A 301 (-4.6A)
SAH  A 301 ( 4.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
 1.39A 4lg1B-4lecA:
25.4		 4lg1B-4lecA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		7 / 12 TRP A  47
ALA A  50
GLY A  73
GLY A  75
TRP A 125
ALA A 143
TYR A 147
 SAH  A 301 (-4.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
 0.38A 4lg1B-4lecA:
25.4		 4lg1B-4lecA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		6 / 12 TRP A  47
ALA A  49
GLY A  73
TRP A 125
ALA A 143
TYR A 147
 SAH  A 301 (-4.6A)
SAH  A 301 ( 4.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
 1.43A 4lg1C-4lecA:
25.2		 4lg1C-4lecA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		8 / 12 TRP A  47
ALA A  50
GLY A  73
GLY A  75
ASP A  94
TRP A 125
ALA A 143
TYR A 147
 SAH  A 301 (-4.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
 0.26A 4lg1C-4lecA:
25.2		 4lg1C-4lecA:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 11 ASP A  94
ALA A  98
TYR A 147
GLY A  77
GLY A 142
 SAH  A 301 (-2.9A)
SAH  A 301 ( 4.0A)
SAH  A 301 (-4.4A)
None
None
 1.04A 4xp4A-4lecA:
undetectable		 4xp4A-4lecA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		3 / 3 ASP A 180
ARG A 176
TYR A 177
 None
 0.92A 5a7mA-4lecA:
2.3		 5a7mA-4lecA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		3 / 3 ASP A 180
ARG A 176
TYR A 177
 None
 0.91A 5a7mB-4lecA:
2.9		 5a7mB-4lecA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 12 VAL A  90
GLU A  71
LEU A  86
ALA A  83
LEU A 170
 None
SAH  A 301 ( 4.7A)
None
None
None
 1.10A 5nd7B-4lecA:
undetectable		 5nd7B-4lecA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		5 / 10 LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
 None
 1.49A 6bsiA-4lecA:
undetectable		 6bsiA-4lecA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens) 		4 / 4 VAL A  52
ALA A  50
PHE A  26
PHE A  24
 None
SAH  A 301 (-3.3A)
None
None
 1.43A 6cbdA-4lecA:
2.3		 6cbdA-4lecA:
13.41