SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4leh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		4 / 6 TYR A 147
PHE A  34
TYR A  33
LEU A 107
 SO4  A 203 (-4.7A)
None
None
None
 1.17A 2w98A-4lehA:
undetectable
2w98B-4lehA:
undetectable		 2w98A-4lehA:
19.34
2w98B-4lehA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		5 / 12 ILE A 161
GLY A 122
ASN A 124
ARG A 149
ILE A 112
 None
 1.47A 4djfA-4lehA:
undetectable		 4djfA-4lehA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		4 / 5 ILE A  53
LEU A  49
ASP A 131
GLU A 134
 None
 0.81A 4nkxB-4lehA:
undetectable		 4nkxB-4lehA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		3 / 3 ASP A  38
LEU A  37
PHE A  34
 None
 0.67A 4pthA-4lehA:
undetectable		 4pthA-4lehA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		3 / 3 LEU A 111
PHE A 155
ILE A 112
 None
 0.69A 5dzk1-4lehA:
undetectable
5dzkF-4lehA:
undetectable
5dzkM-4lehA:
undetectable		 5dzk1-4lehA:
3.28
5dzkF-4lehA:
19.82
5dzkM-4lehA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		3 / 3 THR A  55
SER A  56
TYR A  57
 None
None
SO4  A 203 (-4.6A)
 0.85A 5jsdA-4lehA:
undetectable		 5jsdA-4lehA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		3 / 3 THR A  55
SER A  56
TYR A  57
 None
None
SO4  A 203 (-4.6A)
 0.86A 5jsdB-4lehA:
undetectable		 5jsdB-4lehA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		3 / 3 THR A  55
SER A  56
TYR A  57
 None
None
SO4  A 203 (-4.6A)
 0.85A 5jsdC-4lehA:
undetectable		 5jsdC-4lehA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		3 / 3 THR A  55
SER A  56
TYR A  57
 None
None
SO4  A 203 (-4.6A)
 0.86A 5jseA-4lehA:
undetectable		 5jseA-4lehA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		3 / 3 THR A  55
SER A  56
TYR A  57
 None
None
SO4  A 203 (-4.6A)
 0.85A 5jseB-4lehA:
undetectable		 5jseB-4lehA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		3 / 3 THR A  55
SER A  56
TYR A  57
 None
None
SO4  A 203 (-4.6A)
 0.85A 5jseC-4lehA:
undetectable		 5jseC-4lehA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		5 / 9 TYR A  57
LEU A  37
LEU A  29
THR A  71
VAL A  70
 SO4  A 203 (-4.6A)
None
None
None
None
 1.17A 5mxbA-4lehA:
undetectable		 5mxbA-4lehA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE
([Clostridium]
scindens) 		5 / 11 TYR A  33
LEU A  45
TYR A 129
ASP A  38
THR A 145
 None
 1.38A 6dk1C-4lehA:
undetectable		 6dk1C-4lehA:
18.10