SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lej'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4lej VICILIN
(Pinus
koraiensis) 		3 / 3 VAL A 196
ALA A 197
HIS A 232
 None
 0.69A 1q23C-4lejA:
undetectable		 1q23C-4lejA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4lej VICILIN
(Pinus
koraiensis) 		3 / 3 VAL A 196
ALA A 197
HIS A 232
 None
 0.66A 1q23H-4lejA:
undetectable		 1q23H-4lejA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4lej VICILIN
(Pinus
koraiensis) 		3 / 3 VAL A 196
ALA A 197
HIS A 232
 None
 0.61A 1q23G-4lejA:
undetectable		 1q23G-4lejA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4lej VICILIN
(Pinus
koraiensis) 		3 / 3 VAL A 196
ALA A 197
HIS A 232
 None
 0.77A 1q23L-4lejA:
undetectable		 1q23L-4lejA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4lej VICILIN
(Pinus
koraiensis) 		3 / 3 VAL A 196
ALA A 197
HIS A 232
 None
 0.64A 1q23J-4lejA:
undetectable		 1q23J-4lejA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4lej VICILIN
(Pinus
koraiensis) 		4 / 8 ILE A 324
SER A 323
ASP A 397
LEU A 180
 None
PO4  A 502 (-3.6A)
None
None
 0.87A 2cdqA-4lejA:
undetectable		 2cdqA-4lejA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lej VICILIN
(Pinus
koraiensis) 		4 / 6 ILE A 177
TYR A 195
LEU A 175
MET A 117
 None
None
None
GOL  A 503 ( 4.9A)
 0.73A 3adsA-4lejA:
undetectable		 3adsA-4lejA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4lej VICILIN
(Pinus
koraiensis) 		3 / 3 LYS A 125
ARG A 103
LYS A 320
 None
 1.13A 3okxA-4lejA:
undetectable		 3okxA-4lejA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4lej VICILIN
(Pinus
koraiensis) 		5 / 11 THR A 285
PHE A 304
LEU A 270
VAL A 155
LEU A 394
 None
 1.08A 4g1bB-4lejA:
undetectable		 4g1bB-4lejA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 4lej VICILIN
(Pinus
koraiensis) 		5 / 9 THR A 285
PHE A 304
LEU A 270
VAL A 155
LEU A 394
 None
 1.06A 4g1bC-4lejA:
undetectable		 4g1bC-4lejA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4lej VICILIN
(Pinus
koraiensis) 		5 / 12 THR A 285
PHE A 304
LEU A 270
VAL A 155
LEU A 394
 None
 1.10A 4g1bD-4lejA:
undetectable		 4g1bD-4lejA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4lej VICILIN
(Pinus
koraiensis) 		5 / 12 ILE A 122
TYR A 139
VAL A 146
LEU A 150
LEU A 128
 GOL  A 503 ( 4.6A)
None
None
None
None
 1.31A 4qztA-4lejA:
undetectable		 4qztA-4lejA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4lej VICILIN
(Pinus
koraiensis) 		3 / 4 ARG A 431
GLY A 432
GLU A 434
 None
 0.65A 4z2dB-4lejA:
undetectable
4z2dC-4lejA:
undetectable		 4z2dB-4lejA:
22.44
4z2dC-4lejA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4lej VICILIN
(Pinus
koraiensis) 		3 / 3 ARG A 286
THR A 400
ASP A 397
 None
 0.80A 5g5gA-4lejA:
undetectable
5g5gB-4lejA:
undetectable		 5g5gA-4lejA:
18.98
5g5gB-4lejA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4lej VICILIN
(Pinus
koraiensis) 		4 / 5 PHE A 156
ILE A 137
GLN A 264
ARG A 148
 None
 1.49A 5jm4A-4lejA:
undetectable		 5jm4A-4lejA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4lej VICILIN
(Pinus
koraiensis) 		4 / 4 PHE A 156
ILE A 137
GLN A 264
ARG A 148
 None
 1.36A 5jm4B-4lejA:
undetectable		 5jm4B-4lejA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4lej VICILIN
(Pinus
koraiensis) 		3 / 3 VAL A 196
HIS A 162
VAL A 140
 None
 0.59A 5jmnC-4lejA:
undetectable		 5jmnC-4lejA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4lej VICILIN
(Pinus
koraiensis) 		4 / 6 ASN A 403
ASN A 318
ARG A 286
GLU A 406
 None
PO4  A 502 ( 4.8A)
None
None
 0.96A 5uigA-4lejA:
undetectable		 5uigA-4lejA:
21.07