SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4leo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		4 / 6 THR C  13
LEU C  44
GLY C  42
TYR C  34
 None
 1.28A 1gtiC-4leoC:
undetectable		 1gtiC-4leoC:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		5 / 12 LEU C 342
LEU C 378
LEU C 411
LEU C 427
ILE C 338
 None
 1.06A 1s9pC-4leoC:
undetectable		 1s9pC-4leoC:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		5 / 12 GLY C 314
GLY C 340
GLY C 376
ASP C 343
SER C 319
 None
 1.11A 1wg8B-4leoC:
undetectable		 1wg8B-4leoC:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		3 / 3 GLY C 376
TYR C 377
SER C 403
 None
 0.69A 2xatA-4leoC:
undetectable		 2xatA-4leoC:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		4 / 8 ILE C 374
SER C 403
GLY C 376
SER C 317
 None
 0.90A 3lslA-4leoC:
undetectable
3lslD-4leoC:
undetectable		 3lslA-4leoC:
17.79
3lslD-4leoC:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		5 / 11 LEU C 117
ILE C  46
VAL C  68
LEU C  44
VAL C  40
 None
 0.99A 3w67A-4leoC:
undetectable		 3w67A-4leoC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		5 / 12 ILE C 399
PHE C 424
ILE C 435
ILE C 437
LEU C 443
 None
 0.95A 3w67B-4leoC:
undetectable		 3w67B-4leoC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		5 / 12 LEU C 117
ILE C  46
VAL C  68
LEU C  44
VAL C  40
 None
 0.97A 3w68A-4leoC:
undetectable		 3w68A-4leoC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		5 / 12 LEU C 117
ILE C  46
VAL C  68
LEU C  44
VAL C  40
 None
 0.98A 3w68D-4leoC:
undetectable		 3w68D-4leoC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		5 / 12 VAL C 392
ILE C 380
ILE C 346
ASN C 350
LEU C 365
 None
 1.31A 4a84A-4leoC:
undetectable		 4a84A-4leoC:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		4 / 7 THR C 280
LEU C 575
LYS C 578
ASN C 256
 None
 1.07A 4ib4A-4leoC:
undetectable		 4ib4A-4leoC:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		4 / 8 VAL C 128
TRP C 144
LEU C  83
LEU C 120
 None
 1.09A 4jtrA-4leoC:
undetectable		 4jtrA-4leoC:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		4 / 8 LEU C 117
VAL C 100
VAL C 128
LEU C  78
 None
 1.02A 4q0bA-4leoC:
undetectable		 4q0bA-4leoC:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		4 / 7 VAL C 128
TRP C 144
ILE C 147
LEU C  78
 None
 1.02A 4xo7B-4leoC:
undetectable		 4xo7B-4leoC:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		4 / 7 VAL C 128
TRP C 144
ILE C 147
LEU C  80
 None
 1.12A 4xo7B-4leoC:
undetectable		 4xo7B-4leoC:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		5 / 12 LEU C  58
LEU C  80
ILE C  61
VAL C  68
VAL C  70
 None
 0.93A 4y0sA-4leoC:
undetectable		 4y0sA-4leoC:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		4 / 8 GLU C  63
GLY C 265
GLY C 264
VAL C  39
 NAG  C 701 ( 4.7A)
None
None
None
 0.79A 5f8yA-4leoC:
undetectable		 5f8yA-4leoC:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		4 / 7 THR C 280
LEU C 575
LYS C 578
ASN C 256
 None
 1.09A 5tudA-4leoC:
undetectable		 5tudA-4leoC:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		5 / 10 VAL C 324
THR C 315
PHE C 368
LEU C 378
ILE C 380
 None
 1.12A 6d9hR-4leoC:
undetectable		 6d9hR-4leoC:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens) 		3 / 3 LEU C 412
ASN C 468
LEU C 422
 None
 0.76A 6exiD-4leoC:
undetectable		 6exiD-4leoC:
7.98