SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ler'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 12 ASN A 192
TRP A 187
ILE A 179
GLY A 234
ASN A 186
 None
 1.08A 1g60B-4lerA:
undetectable		 1g60B-4lerA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		4 / 4 ALA A 193
ARG A 197
GLN A 344
GLU A 343
 None
 0.91A 1lqtB-4lerA:
undetectable		 1lqtB-4lerA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		4 / 6 ALA A  50
LEU A 109
LEU A 190
LEU A 160
 None
 0.95A 1mt1D-4lerA:
undetectable
1mt1E-4lerA:
undetectable		 1mt1D-4lerA:
13.62
1mt1E-4lerA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		3 / 3 PHE A 217
LEU A 348
MET A 227
 None
 0.80A 1mx1D-4lerA:
undetectable		 1mx1D-4lerA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 9 ILE A 416
ILE A 413
LYS A 420
GLU A 436
ILE A 417
 None
 1.18A 2j9dA-4lerA:
undetectable
2j9dB-4lerA:
undetectable
2j9dC-4lerA:
undetectable		 2j9dA-4lerA:
13.19
2j9dB-4lerA:
13.19
2j9dC-4lerA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 10 LYS A 420
GLU A 436
ILE A 417
ILE A 416
ILE A 413
 None
 1.19A 2j9dD-4lerA:
undetectable
2j9dE-4lerA:
undetectable
2j9dF-4lerA:
undetectable		 2j9dD-4lerA:
13.19
2j9dE-4lerA:
12.98
2j9dF-4lerA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		4 / 6 ASP A 232
TYR A 341
TYR A 180
LEU A 338
 None
 1.03A 2w98A-4lerA:
undetectable
2w98B-4lerA:
undetectable		 2w98A-4lerA:
20.97
2w98B-4lerA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 11 SER A 321
THR A 281
GLN A 282
ALA A 315
GLY A 318
 None
 1.10A 3mg0H-4lerA:
undetectable
3mg0I-4lerA:
undetectable		 3mg0H-4lerA:
21.32
3mg0I-4lerA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		3 / 3 TYR A 434
ASP A 124
ASP A  85
 None
 0.86A 3ou6B-4lerA:
undetectable		 3ou6B-4lerA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 11 SER A 104
GLU A 102
LEU A  42
VAL A  93
THR A  94
 CL  A 501 ( 4.2A)
None
None
None
None
 1.24A 3tbgA-4lerA:
undetectable		 3tbgA-4lerA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 9 VAL A  93
GLU A  99
GLY A  45
SER A  49
ALA A  50
 None
 1.18A 4fwdA-4lerA:
undetectable		 4fwdA-4lerA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 9 VAL A 311
GLU A  71
ILE A  66
GLY A 257
ALA A 315
 None
 1.12A 4fwdA-4lerA:
undetectable		 4fwdA-4lerA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 11 SER A 321
THR A 281
GLN A 282
ALA A 315
GLY A 318
 None
 1.21A 5bxnV-4lerA:
undetectable
5bxnW-4lerA:
undetectable		 5bxnV-4lerA:
21.15
5bxnW-4lerA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 12 SER A 321
THR A 281
GLN A 282
ALA A 315
GLY A 318
 None
 1.15A 5l5zH-4lerA:
undetectable
5l5zI-4lerA:
undetectable		 5l5zH-4lerA:
21.59
5l5zI-4lerA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		5 / 12 SER A 321
THR A 281
GLN A 282
ALA A 315
GLY A 318
 None
 1.18A 5l5zV-4lerA:
undetectable
5l5zW-4lerA:
undetectable		 5l5zV-4lerA:
21.59
5l5zW-4lerA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		4 / 4 GLN A 282
THR A 283
LEU A 268
LEU A 276
 None
 1.29A 5m5kB-4lerA:
undetectable		 5m5kB-4lerA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		4 / 6 MET A 227
ALA A 193
LEU A 196
ILE A 220
 None
 0.82A 5mvmB-4lerA:
2.5
5mvmC-4lerA:
2.5		 5mvmB-4lerA:
11.34
5mvmC-4lerA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		4 / 6 PRO A 433
PRO A 423
LEU A 422
PHE A 425
 None
 1.06A 5tl8A-4lerA:
undetectable		 5tl8A-4lerA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		4 / 4 LEU A 387
ASP A 273
PRO A 274
ARG A 275
 None
 0.92A 6fgdA-4lerA:
undetectable		 6fgdA-4lerA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING
(Bacteroides
vulgatus) 		4 / 4 ASP A 124
ILE A 128
PRO A 129
LEU A 121
 None
 1.48A 6mkeB-4lerA:
undetectable		 6mkeB-4lerA:
11.05