SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lf0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4lf0 ALIPHATIC AMIDASE
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 GLY A  64
ALA A  76
ALA A  77
PHE A  57
LEU A 102
 None
 0.98A 3mteB-4lf0A:
undetectable		 3mteB-4lf0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4lf0 ALIPHATIC AMIDASE
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 GLY A  64
ALA A  76
ALA A  77
PHE A  57
LEU A 102
 None
 0.99A 3p2kC-4lf0A:
undetectable		 3p2kC-4lf0A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4lf0 ALIPHATIC AMIDASE
(Bacillus
sp.
(in:
Bacteria)) 		3 / 3 THR A  12
SER A 259
ARG A   2
 None
 0.82A 3phnA-4lf0A:
undetectable		 3phnA-4lf0A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4lf0 ALIPHATIC AMIDASE
(Bacillus
sp.
(in:
Bacteria)) 		5 / 12 ALA A 256
ARG A   2
SER A   8
TYR A 255
VAL A  17
 None
 1.32A 3qxvE-4lf0A:
undetectable		 3qxvE-4lf0A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4lf0 ALIPHATIC AMIDASE
(Bacillus
sp.
(in:
Bacteria)) 		5 / 11 ILE A 186
LEU A 121
ALA A 183
ILE A 263
VAL A 258
 None
 1.04A 4h1nA-4lf0A:
undetectable		 4h1nA-4lf0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4lf0 ALIPHATIC AMIDASE
(Bacillus
sp.
(in:
Bacteria)) 		4 / 5 ILE A 122
LYS A  36
ILE A  38
VAL A  42
 None
 0.99A 5jmnA-4lf0A:
undetectable		 5jmnA-4lf0A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4lf0 ALIPHATIC AMIDASE
(Bacillus
sp.
(in:
Bacteria)) 		3 / 3 GLN A 190
TYR A 192
ASN A 219
 None
 1.01A 6dwdC-4lf0A:
undetectable		 6dwdC-4lf0A:
20.65