SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 GLY A 141
SER A 140
MET A 145
LEU A 176
LEU A 136
 None
None
IPE  A 301 ( 4.2A)
None
None
 1.47A 1a8uB-4lfeA:
undetectable		 1a8uB-4lfeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 ILE A 204
LEU A 253
LEU A 281
PHE A 209
ILE A 205
 None
 1.20A 1g5yB-4lfeA:
3.2		 1g5yB-4lfeA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.90A 1rqjA-4lfeA:
34.3		 1rqjA-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.68A 1rqjA-4lfeA:
34.3		 1rqjA-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.43A 1rqjA-4lfeA:
34.3		 1rqjA-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.88A 1rqjB-4lfeA:
34.3		 1rqjB-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.65A 1rqjB-4lfeA:
34.3		 1rqjB-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.41A 1rqjB-4lfeA:
34.3		 1rqjB-4lfeA:
41.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.88A 1yhlA-4lfeA:
25.9		 1yhlA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.69A 1yhlA-4lfeA:
25.9		 1yhlA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.90A 1yq7A-4lfeA:
26.0		 1yq7A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.69A 1yq7A-4lfeA:
26.0		 1yq7A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.50A 1yq7A-4lfeA:
26.0		 1yq7A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.93A 1yv5A-4lfeA:
26.0		 1yv5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.72A 1yv5A-4lfeA:
26.0		 1yv5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 1yv5A-4lfeA:
26.0		 1yv5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.05A 1zw5A-4lfeA:
26.2		 1zw5A-4lfeA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.79A 1zw5A-4lfeA:
26.2		 1zw5A-4lfeA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.56A 1zw5A-4lfeA:
26.2		 1zw5A-4lfeA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.97A 2e91A-4lfeA:
20.1		 2e91A-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.77A 2e91A-4lfeA:
20.1		 2e91A-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.54A 2e91A-4lfeA:
20.1		 2e91A-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.15A 2e91B-4lfeA:
19.4		 2e91B-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.73A 2e91B-4lfeA:
19.4		 2e91B-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 ARG A  89
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 0.90A 2f89F-4lfeA:
26.2		 2f89F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.70A 2f89F-4lfeA:
26.2		 2f89F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.96A 2f8cF-4lfeA:
26.2		 2f8cF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.73A 2f8cF-4lfeA:
26.2		 2f8cF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 2f8cF-4lfeA:
26.2		 2f8cF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.74A 2f8zF-4lfeA:
26.1		 2f8zF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 2f8zF-4lfeA:
26.1		 2f8zF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.81A 2f8zF-4lfeA:
26.1		 2f8zF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.07A 2f94F-4lfeA:
25.9		 2f94F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 12 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.88A 2f94F-4lfeA:
25.9		 2f94F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.94A 2f9kF-4lfeA:
25.9		 2f9kF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.71A 2f9kF-4lfeA:
25.9		 2f9kF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 2f9kF-4lfeA:
25.9		 2f9kF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.85A 2o1oA-4lfeA:
24.8		 2o1oA-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.44A 2o1oA-4lfeA:
24.8		 2o1oA-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.82A 2o1oB-4lfeA:
25.8		 2o1oB-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.58A 2o1oB-4lfeA:
25.8		 2o1oB-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 7 LEU A 264
PHE A 273
ILE A 278
PHE A 181
 None
 0.95A 2opxA-4lfeA:
undetectable		 2opxA-4lfeA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.90A 2q58A-4lfeA:
24.9		 2q58A-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
ASP A 217
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
None
 1.24A 2q58A-4lfeA:
24.9		 2q58A-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.69A 2q58A-4lfeA:
24.9		 2q58A-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.90A 2q58B-4lfeA:
25.3		 2q58B-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.61A 2q58B-4lfeA:
25.3		 2q58B-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.95A 2qisA-4lfeA:
25.9		 2qisA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.70A 2qisA-4lfeA:
25.9		 2qisA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		3 / 3 SER A 138
HIS A  71
ASP A  78
 None
None
MG  A 302 (-2.5A)
 0.74A 2wa2B-4lfeA:
undetectable		 2wa2B-4lfeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 3ez3A-4lfeA:
25.9		 3ez3A-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 3ez3A-4lfeA:
25.9		 3ez3A-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.82A 3ez3A-4lfeA:
25.9		 3ez3A-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.99A 3ez3B-4lfeA:
25.9		 3ez3B-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.75A 3ez3B-4lfeA:
25.9		 3ez3B-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.49A 3ez3B-4lfeA:
25.9		 3ez3B-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.78A 3ez3C-4lfeA:
26.0		 3ez3C-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.54A 3ez3C-4lfeA:
26.0		 3ez3C-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.87A 3ez3C-4lfeA:
26.0		 3ez3C-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.92A 3ez3D-4lfeA:
25.7		 3ez3D-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.72A 3ez3D-4lfeA:
25.7		 3ez3D-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 3ez3D-4lfeA:
25.7		 3ez3D-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.84A 3ibaA-4lfeA:
25.8		 3ibaA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.68A 3ibaA-4lfeA:
25.8		 3ibaA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.45A 3ibaA-4lfeA:
25.8		 3ibaA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.94A 3ldwA-4lfeA:
25.9		 3ldwA-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 3ldwA-4lfeA:
25.9		 3ldwA-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 3ldwA-4lfeA:
25.9		 3ldwA-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.02A 3ldwB-4lfeA:
25.9		 3ldwB-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 3ldwB-4lfeA:
25.9		 3ldwB-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.98A 3ldwC-4lfeA:
26.0		 3ldwC-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.78A 3ldwC-4lfeA:
26.0		 3ldwC-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.56A 3ldwC-4lfeA:
26.0		 3ldwC-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.01A 3ldwD-4lfeA:
25.6		 3ldwD-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 3ldwD-4lfeA:
25.6		 3ldwD-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.53A 3ldwD-4lfeA:
25.6		 3ldwD-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.94A 3n45F-4lfeA:
25.9		 3n45F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.73A 3n45F-4lfeA:
25.9		 3n45F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 3n45F-4lfeA:
25.9		 3n45F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.96A 3n46F-4lfeA:
26.0		 3n46F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 3n46F-4lfeA:
26.0		 3n46F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.53A 3n46F-4lfeA:
26.0		 3n46F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 ASP A  78
GLY A  37
PHE A 209
ILE A  11
THR A  72
 MG  A 302 (-2.5A)
None
None
None
None
 1.07A 3pwwA-4lfeA:
undetectable		 3pwwA-4lfeA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 GLY A 117
ALA A 115
HIS A  12
GLU A  17
CYH A  16
 None
 1.40A 3s8pA-4lfeA:
undetectable		 3s8pA-4lfeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 GLY A 117
ALA A 115
HIS A  12
GLU A  17
CYH A  16
 None
 1.41A 3s8pB-4lfeA:
2.3		 3s8pB-4lfeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 6 LEU A   4
ALA A  65
THR A  10
LEU A  46
 None
 0.96A 3t3zA-4lfeA:
undetectable		 3t3zA-4lfeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 6 LEU A   4
ALA A  65
THR A  10
LEU A  46
 None
 0.94A 3t3zB-4lfeA:
undetectable		 3t3zB-4lfeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 6 LEU A   4
ALA A  65
THR A  10
LEU A  46
 None
 0.97A 3t3zD-4lfeA:
undetectable		 3t3zD-4lfeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 GLY A 117
ALA A 115
HIS A  12
GLU A  17
CYH A  16
 None
 1.38A 4bupA-4lfeA:
undetectable		 4bupA-4lfeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 GLY A 117
ALA A 115
HIS A  12
GLU A  17
CYH A  16
 None
 1.40A 4bupB-4lfeA:
undetectable		 4bupB-4lfeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.69A 4kfaA-4lfeA:
25.8		 4kfaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.44A 4kfaA-4lfeA:
25.8		 4kfaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 LEU A  75
GLN A 149
LYS A 172
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.88A 4kfaA-4lfeA:
25.8		 4kfaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.68A 4kpdA-4lfeA:
25.9		 4kpdA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.46A 4kpdA-4lfeA:
25.9		 4kpdA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.83A 4kpdA-4lfeA:
25.9		 4kpdA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ARG A  89
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 0.97A 4kpjA-4lfeA:
25.8		 4kpjA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ARG A  89
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.74A 4kpjA-4lfeA:
25.8		 4kpjA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
 0.53A 4kpjA-4lfeA:
25.8		 4kpjA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.74A 4kq5A-4lfeA:
25.9		 4kq5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 4kq5A-4lfeA:
25.9		 4kq5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.86A 4kq5A-4lfeA:
25.9		 4kq5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.70A 4kqsA-4lfeA:
26.0		 4kqsA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.49A 4kqsA-4lfeA:
26.0		 4kqsA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.83A 4kqsA-4lfeA:
26.0		 4kqsA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ARG A  89
GLN A 149
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
None
None
 0.98A 4n9uA-4lfeA:
25.7		 4n9uA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
None
 0.77A 4n9uA-4lfeA:
25.7		 4n9uA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 0.53A 4n9uA-4lfeA:
25.7		 4n9uA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 12 LEU A  75
ASP A  78
ARG A  89
GLN A 149
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
None
 0.94A 4ng6A-4lfeA:
25.9		 4ng6A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 12 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 0.79A 4ng6A-4lfeA:
25.9		 4ng6A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 LEU A  75
GLN A 149
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
None
None
None
 1.06A 4ng6A-4lfeA:
25.9		 4ng6A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.96A 4nkeA-4lfeA:
25.8		 4nkeA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.73A 4nkeA-4lfeA:
25.8		 4nkeA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 4nkeA-4lfeA:
25.8		 4nkeA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ARG A  89
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 0.87A 4nkfA-4lfeA:
25.7		 4nkfA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ARG A  89
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.68A 4nkfA-4lfeA:
25.7		 4nkfA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
 0.52A 4nkfA-4lfeA:
25.7		 4nkfA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.94A 4nuaA-4lfeA:
25.9		 4nuaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.72A 4nuaA-4lfeA:
25.9		 4nuaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 4nuaA-4lfeA:
25.9		 4nuaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ARG A  89
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 0.93A 4oguA-4lfeA:
25.7		 4oguA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ARG A  89
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.73A 4oguA-4lfeA:
25.7		 4oguA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
 0.54A 4oguA-4lfeA:
25.7		 4oguA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.01A 4p0vA-4lfeA:
26.0		 4p0vA-4lfeA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 4p0vA-4lfeA:
26.0		 4p0vA-4lfeA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 4p0vA-4lfeA:
26.0		 4p0vA-4lfeA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.74A 4p0wA-4lfeA:
25.9		 4p0wA-4lfeA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 4p0wA-4lfeA:
25.9		 4p0wA-4lfeA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 11 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.86A 4p0wA-4lfeA:
25.9		 4p0wA-4lfeA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 ILE A 204
ALA A 208
ILE A 278
LEU A 264
ILE A 201
 None
 1.04A 4p3rA-4lfeA:
undetectable		 4p3rA-4lfeA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 ILE A 204
ALA A 208
ILE A 278
LEU A 264
ILE A 201
 None
 1.05A 4pthA-4lfeA:
undetectable		 4pthA-4lfeA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.99A 4q23A-4lfeA:
25.4		 4q23A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.73A 4q23A-4lfeA:
25.4		 4q23A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.48A 4q23A-4lfeA:
25.4		 4q23A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.90A 4rxdA-4lfeA:
25.0		 4rxdA-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.70A 4rxdA-4lfeA:
25.0		 4rxdA-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 4rxdA-4lfeA:
25.0		 4rxdA-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.88A 4rxdB-4lfeA:
25.3		 4rxdB-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.67A 4rxdB-4lfeA:
25.3		 4rxdB-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 4rxdB-4lfeA:
25.3		 4rxdB-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.89A 4rxdC-4lfeA:
25.0		 4rxdC-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.69A 4rxdC-4lfeA:
25.0		 4rxdC-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 4rxdC-4lfeA:
25.0		 4rxdC-4lfeA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 8 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.74A 4umjA-4lfeA:
33.0		 4umjA-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 8 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
MET A 145
LYS A 172
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 4.2A)
IPE  A 301 (-3.0A)
 0.78A 4umjA-4lfeA:
33.0		 4umjA-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 9 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.54A 4umjB-4lfeA:
33.5		 4umjB-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 9 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
MET A 145
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 4.2A)
IPE  A 301 (-3.0A)
None
 0.70A 4umjB-4lfeA:
33.5		 4umjB-4lfeA:
40.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 11 LEU A  80
PHE A  99
GLY A  73
LEU A 111
SER A  32
 None
 1.34A 4wnuC-4lfeA:
undetectable		 4wnuC-4lfeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 6 HIS A  71
GLY A  37
GLU A  68
ARG A  39
 None
 1.10A 4zbqA-4lfeA:
3.5		 4zbqA-4lfeA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.91A 5cg5A-4lfeA:
25.4		 5cg5A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.69A 5cg5A-4lfeA:
25.4		 5cg5A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.49A 5cg5A-4lfeA:
25.4		 5cg5A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.95A 5cg6A-4lfeA:
25.9		 5cg6A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.71A 5cg6A-4lfeA:
25.9		 5cg6A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.47A 5cg6A-4lfeA:
25.9		 5cg6A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 GLY A 117
ALA A 115
HIS A  12
GLU A  17
CYH A  16
 None
 1.47A 5cprB-4lfeA:
undetectable		 5cprB-4lfeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 LEU A  75
ARG A  89
LYS A 172
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.93A 5eroA-4lfeA:
24.4		 5eroA-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
LYS A 172
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
 0.76A 5eroA-4lfeA:
24.4		 5eroA-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 ARG A  89
LYS A 172
GLN A 210
ASP A 213
ASP A 214
 IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 1.16A 5eroB-4lfeA:
24.0		 5eroB-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 ARG A  89
LYS A 172
GLN A 210
ASP A 213
ASP A 214
 IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 1.12A 5eroC-4lfeA:
24.4		 5eroC-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 ASP A  78
ASP A  79
ASP A  84
ARG A  89
LYS A 172
 MG  A 302 (-2.5A)
None
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
 0.84A 5eroC-4lfeA:
24.4		 5eroC-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 7 GLY A  73
ALA A 104
ASP A 109
PHE A 112
 None
 0.86A 5mvsA-4lfeA:
undetectable		 5mvsA-4lfeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 8 GLY A  73
ALA A 104
ASP A 109
PHE A 112
 None
 0.82A 5mvsB-4lfeA:
undetectable		 5mvsB-4lfeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 GLY A 117
ALA A 115
HIS A  12
GLU A  17
CYH A  16
 None
 1.36A 5wbvA-4lfeA:
undetectable		 5wbvA-4lfeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 GLY A 117
ALA A 115
HIS A  12
GLU A  17
CYH A  16
 None
 1.36A 5wbvB-4lfeA:
2.3		 5wbvB-4lfeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 8 ILE A  40
LEU A 285
ALA A 260
LEU A 264
 None
 0.77A 5y7pE-4lfeA:
undetectable		 5y7pE-4lfeA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 ASP A  78
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 1.20A 6g31A-4lfeA:
23.3		 6g31A-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.88A 6g31A-4lfeA:
23.3		 6g31A-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 6 ASP A  78
ASP A  84
ARG A  89
GLN A 149
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 0.88A 6g31B-4lfeA:
23.5		 6g31B-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 5 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 1.04A 6g31C-4lfeA:
23.2		 6g31C-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 LEU A  75
ASP A  78
ARG A  89
GLN A 149
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 0.82A 6g31D-4lfeA:
22.6		 6g31D-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 0.71A 6g31D-4lfeA:
22.6		 6g31D-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 4 LEU A  75
ASP A  78
ASP A  84
ARG A  89
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
 0.45A 6g31E-4lfeA:
17.4		 6g31E-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 ASP A  78
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.87A 6g31G-4lfeA:
22.4		 6g31G-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.70A 6g31G-4lfeA:
22.4		 6g31G-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 6 LEU A  75
ASP A  78
ARG A  89
GLN A 149
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 1.02A 6g31J-4lfeA:
23.5		 6g31J-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 6 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 1.01A 6g31J-4lfeA:
23.5		 6g31J-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 4 ASP A  78
ASP A  84
ARG A  89
GLN A 149
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 0.63A 6g31K-4lfeA:
21.8		 6g31K-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 6 ASP A  78
ASP A  84
ARG A  89
GLN A 149
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 0.74A 6g31L-4lfeA:
23.3		 6g31L-4lfeA:
13.24