SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lfy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		4 / 5 HIS A  31
HIS A 154
HIS A 192
ASP A 268
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
ZN  A 401 (-2.7A)
 0.59A 1e9yB-4lfyA:
17.8		 1e9yB-4lfyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		5 / 6 HIS A  31
HIS A  33
HIS A 154
HIS A 192
ASP A 268
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
ZN  A 401 (-2.7A)
 0.64A 1fweC-4lfyA:
5.8		 1fweC-4lfyA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		4 / 6 PHE A 183
GLN A 145
LYS A 187
VAL A 188
 None
None
EDO  A 403 (-2.8A)
None
 1.27A 1l2iB-4lfyA:
undetectable		 1l2iB-4lfyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 252
PHE A 264
GLY A 266
ILE A  55
PHE A 320
 None
 1.25A 2zznB-4lfyA:
undetectable		 2zznB-4lfyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		5 / 12 ASP A 268
HIS A  31
HIS A  33
ALA A 284
CYH A 239
 ZN  A 401 (-2.7A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
None
None
 1.09A 3r2jC-4lfyA:
undetectable		 3r2jC-4lfyA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		4 / 5 HIS A  31
HIS A 154
HIS A 192
ASP A 268
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
ZN  A 401 (-2.7A)
 0.57A 4h9mA-4lfyA:
5.4		 4h9mA-4lfyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		5 / 6 HIS A  31
HIS A  33
HIS A 154
HIS A 192
ASP A 268
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
ZN  A 401 (-2.7A)
 0.47A 4ubpC-4lfyA:
18.7		 4ubpC-4lfyA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A 211
ARG A 262
ARG A 180
 None
 0.67A 4yiaB-4lfyA:
undetectable		 4yiaB-4lfyA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A 151
THR A 140
LEU A 141
THR A  99
 None
 0.80A 4z90A-4lfyA:
undetectable
4z90B-4lfyA:
undetectable
4z90C-4lfyA:
undetectable
4z90D-4lfyA:
undetectable
4z90E-4lfyA:
undetectable		 4z90A-4lfyA:
23.82
4z90B-4lfyA:
23.82
4z90C-4lfyA:
23.82
4z90D-4lfyA:
23.82
4z90E-4lfyA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		4 / 8 THR A 140
LEU A 141
LEU A 118
LEU A 151
 None
None
KCX  A 117 ( 4.5A)
None
 0.64A 4z90F-4lfyA:
undetectable
4z90G-4lfyA:
undetectable
4z90H-4lfyA:
undetectable
4z90I-4lfyA:
undetectable
4z90J-4lfyA:
undetectable		 4z90F-4lfyA:
23.82
4z90G-4lfyA:
23.82
4z90H-4lfyA:
23.82
4z90I-4lfyA:
23.82
4z90J-4lfyA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		5 / 11 HIS A 291
THR A 217
SER A 269
TYR A 223
LEU A 339
 None
 1.25A 5albH-4lfyA:
undetectable		 5albH-4lfyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A 240
HIS A 192
THR A 194
CYH A 239
 None
ZN  A 402 (-3.2A)
None
None
 1.46A 5eu8A-4lfyA:
undetectable		 5eu8A-4lfyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 228
LEU A 164
GLY A 285
ALA A 284
LEU A 240
 None
 1.12A 5jvzB-4lfyA:
undetectable		 5jvzB-4lfyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A 188
ARG A 167
PRO A 120
 None
 0.80A 5koxA-4lfyA:
undetectable		 5koxA-4lfyA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		5 / 8 ASP A 268
HIS A 192
HIS A 154
PRO A 241
HIS A  33
 ZN  A 401 (-2.7A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
None
ZN  A 401 (-3.3A)
 1.42A 5nekB-4lfyA:
3.5		 5nekB-4lfyA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A  93
VAL A 116
MET A 144
CYH A 137
 None
KCX  A 117 ( 3.0A)
None
None
 1.07A 5te0A-4lfyA:
undetectable		 5te0A-4lfyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		4 / 6 PHE A 183
PRO A 184
GLY A 185
LYS A 187
 None
None
None
EDO  A 403 (-2.8A)
 0.97A 5x24A-4lfyA:
undetectable		 5x24A-4lfyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		4 / 6 GLU A 294
LEU A 295
LEU A 290
LEU A 339
 None
 1.17A 5yvnA-4lfyA:
undetectable		 5yvnA-4lfyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4lfy DIHYDROOROTASE
(Burkholderia
cenocepacia) 		3 / 3 ALA A 313
PHE A  51
GLN A  50
 None
 0.84A 6eceA-4lfyA:
undetectable		 6eceA-4lfyA:
25.20