SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		5 / 12 ALA A  46
GLY A  75
GLY A  79
LEU A  97
LEU A 100
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.8A)
 0.78A 1ej0A-4lg1A:
10.4		 1ej0A-4lg1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		4 / 5 LYS A 125
LEU A  97
GLU A 128
LEU A 100
 UNX  A 306 (-4.2A)
SAM  A 301 (-4.4A)
None
SAM  A 301 ( 4.8A)
 1.19A 1eta2-4lg1A:
undetectable		 1eta2-4lg1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		4 / 6 LYS A 125
LEU A  97
GLU A 128
THR A 158
 UNX  A 306 (-4.2A)
SAM  A 301 (-4.4A)
None
None
 1.13A 1etb2-4lg1A:
undetectable		 1etb2-4lg1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		5 / 12 LEU A  20
CYH A 172
ASP A  44
ALA A  45
ALA A 143
 None
None
UNX  A 311 ( 3.8A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
 1.13A 2br4A-4lg1A:
7.9		 2br4A-4lg1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		5 / 12 TYR A 210
CYH A 172
ASP A  44
ALA A  45
ALA A 143
 None
None
UNX  A 311 ( 3.8A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
 1.10A 2br4A-4lg1A:
7.9		 2br4A-4lg1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		5 / 12 TYR A 210
CYH A 172
ASP A  44
ALA A  45
ALA A 143
 None
None
UNX  A 311 ( 3.8A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
 1.11A 2br4B-4lg1A:
8.5		 2br4B-4lg1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		5 / 11 LEU A  53
PHE A  58
TYR A 219
LEU A 141
ILE A 170
 None
 1.43A 3o94C-4lg1A:
3.4		 3o94C-4lg1A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		5 / 11 LEU A  53
PHE A  58
TYR A 219
LEU A 141
ILE A 170
 None
 1.42A 3o94D-4lg1A:
3.2		 3o94D-4lg1A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		5 / 12 GLY A  82
GLY A  79
THR A  78
ASN A 111
VAL A  71
 None
 1.08A 3sglA-4lg1A:
8.4		 3sglA-4lg1A:
15.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		6 / 12 GLY A  75
ASP A  96
LEU A  97
LEU A 100
TRP A 126
TYR A 148
 SAM  A 301 (-3.5A)
SAM  A 301 (-2.9A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.6A)
 1.09A 4lg1A-4lg1A:
42.9		 4lg1A-4lg1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		8 / 12 TRP A  43
ALA A  45
GLY A  75
LEU A  97
TRP A 126
ALA A 143
TYR A 148
GLU A 150
 SAM  A 301 (-3.6A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.6A)
SAM  A 301 ( 4.8A)
 1.34A 4lg1A-4lg1A:
42.9		 4lg1A-4lg1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		11 / 12 TRP A  43
ALA A  46
GLY A  75
GLY A  77
ASP A  96
LEU A  97
LEU A 100
TRP A 126
ALA A 143
TYR A 148
GLU A 150
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.3A)
SAM  A 301 (-2.9A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.6A)
SAM  A 301 ( 4.8A)
 0.02A 4lg1A-4lg1A:
42.9		 4lg1A-4lg1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		5 / 12 GLY A  75
LEU A  97
LEU A 100
TRP A 126
TYR A 148
 SAM  A 301 (-3.5A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.6A)
 1.14A 4lg1B-4lg1A:
39.7		 4lg1B-4lg1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		9 / 12 TRP A  43
ALA A  45
GLY A  75
LEU A  97
LYS A 125
TRP A 126
ALA A 143
TYR A 148
GLU A 150
 SAM  A 301 (-3.6A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.4A)
UNX  A 306 (-4.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.6A)
SAM  A 301 ( 4.8A)
 1.27A 4lg1B-4lg1A:
39.7		 4lg1B-4lg1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		11 / 12 TRP A  43
ALA A  46
GLY A  75
GLY A  77
LEU A  97
LEU A 100
LYS A 125
TRP A 126
ALA A 143
TYR A 148
GLU A 150
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.8A)
UNX  A 306 (-4.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.6A)
SAM  A 301 ( 4.8A)
 0.22A 4lg1B-4lg1A:
39.7		 4lg1B-4lg1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		6 / 12 CYH A  40
ALA A  80
GLY A  75
GLY A  77
LEU A  97
TRP A 126
 SAM  A 301 ( 4.0A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.4A)
 1.38A 4lg1C-4lg1A:
14.4		 4lg1C-4lg1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		11 / 12 CYH A  40
TRP A  43
ALA A  46
GLY A  75
GLY A  77
ASP A  96
LEU A  97
LEU A 100
TRP A 126
ALA A 143
TYR A 148
 SAM  A 301 ( 4.0A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.3A)
SAM  A 301 (-2.9A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.6A)
 0.20A 4lg1C-4lg1A:
14.4		 4lg1C-4lg1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		6 / 12 GLY A  75
ASP A  96
LEU A  97
LEU A 100
TRP A 126
TYR A 148
 SAM  A 301 (-3.5A)
SAM  A 301 (-2.9A)
SAM  A 301 (-4.4A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.6A)
 1.12A 4lg1C-4lg1A:
14.4		 4lg1C-4lg1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		7 / 12 TRP A  43
ALA A  45
GLY A  75
LEU A  97
TRP A 126
ALA A 143
TYR A 148
 SAM  A 301 (-3.6A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.6A)
 1.43A 4lg1C-4lg1A:
14.4		 4lg1C-4lg1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		5 / 12 LEU A  74
GLY A  75
LEU A 104
VAL A 123
VAL A  38
 None
SAM  A 301 (-3.5A)
None
None
None
 1.03A 4okxA-4lg1A:
undetectable		 4okxA-4lg1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D
(Homo
sapiens) 		4 / 5 GLU A  73
VAL A  81
LEU A  53
HIS A  64
 SAM  A 301 ( 4.9A)
None
None
None
 1.45A 6dyoA-4lg1A:
undetectable		 6dyoA-4lg1A:
20.21