SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		5 / 12 ILE A 290
TRP A 291
PHE A 280
LEU A 314
ILE A 335
 None
 1.08A 1rb2B-4lg8A:
undetectable		 1rb2B-4lg8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		5 / 12 ILE A 290
TRP A 291
PHE A 280
LEU A 314
ILE A 335
 None
 1.00A 1rd7A-4lg8A:
undetectable		 1rd7A-4lg8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1502_0
(RAS-RELATED PROTEIN
RAB-9A)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 4 HIS A 273
ILE A 290
GLN A 336
PHE A 280
 None
 1.24A 1s8fA-4lg8A:
0.0
1s8fB-4lg8A:
0.0		 1s8fA-4lg8A:
20.12
1s8fB-4lg8A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		5 / 12 LEU A 238
LEU A 257
VAL A 293
HIS A 217
ILE A 224
 None
 1.15A 1s9pA-4lg8A:
undetectable		 1s9pA-4lg8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		5 / 12 HIS A 217
VAL A 279
VAL A 267
LEU A 260
THR A 259
 None
 1.09A 1z9yA-4lg8A:
undetectable		 1z9yA-4lg8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 8 HIS A 217
ALA A 258
LEU A 238
THR A 239
 None
 0.80A 2it4A-4lg8A:
undetectable		 2it4A-4lg8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 6 GLY A 240
THR A 239
LEU A 216
ASP A 243
 None
 0.96A 3ps9A-4lg8A:
undetectable		 3ps9A-4lg8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 7 ASP A 233
GLN A 276
ASN A 235
ILE A 237
 None
 1.16A 4ii8A-4lg8A:
undetectable		 4ii8A-4lg8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		5 / 12 ILE A 290
TRP A 291
PHE A 280
LEU A 314
ILE A 335
 None
 1.01A 4kjkA-4lg8A:
undetectable		 4kjkA-4lg8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		5 / 12 ILE A 290
TRP A 291
PHE A 280
LEU A 314
ILE A 335
 None
 1.04A 4kjlA-4lg8A:
undetectable		 4kjlA-4lg8A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		5 / 12 ILE A 290
TRP A 291
PHE A 280
LEU A 314
ILE A 335
 None
 1.04A 4p3qA-4lg8A:
undetectable		 4p3qA-4lg8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		5 / 12 ILE A 290
TRP A 291
PHE A 280
LEU A 314
ILE A 335
 None
 1.03A 4p3rA-4lg8A:
undetectable		 4p3rA-4lg8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		3 / 3 SER A 492
TYR A 502
ASP A 496
 None
 0.67A 4rp8C-4lg8A:
undetectable		 4rp8C-4lg8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 4 LEU A 452
ILE A 459
GLY A 453
ILE A 490
 None
 0.79A 5dzk3-4lg8A:
undetectable
5dzkm-4lg8A:
undetectable		 5dzk3-4lg8A:
0.56
5dzkm-4lg8A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 5 ILE A 459
GLY A 453
ILE A 490
LEU A 452
 None
 0.66A 5dzkB-4lg8A:
undetectable
5dzkI-4lg8A:
undetectable
5dzkW-4lg8A:
undetectable		 5dzkB-4lg8A:
21.11
5dzkI-4lg8A:
20.50
5dzkW-4lg8A:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 5 ILE A 459
GLY A 453
ILE A 490
LEU A 452
 None
 0.72A 5dzki-4lg8A:
undetectable
5dzkj-4lg8A:
undetectable
5dzkx-4lg8A:
undetectable		 5dzki-4lg8A:
20.50
5dzkj-4lg8A:
20.50
5dzkx-4lg8A:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 5 ILE A 459
GLY A 453
ILE A 490
LEU A 452
 None
 0.70A 5dzkd-4lg8A:
undetectable
5dzkk-4lg8A:
undetectable
5dzky-4lg8A:
undetectable		 5dzkd-4lg8A:
21.11
5dzkk-4lg8A:
20.50
5dzky-4lg8A:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 4 ILE A 459
GLY A 453
ILE A 490
LEU A 452
 None
 0.63A 5dzkl-4lg8A:
undetectable
5dzkz-4lg8A:
undetectable		 5dzkl-4lg8A:
20.50
5dzkz-4lg8A:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 6 SER A 492
SER A 498
ALA A 211
SER A 212
 None
 1.03A 6bocA-4lg8A:
undetectable
6bocB-4lg8A:
undetectable
6bocC-4lg8A:
undetectable
6bocD-4lg8A:
undetectable		 6bocA-4lg8A:
6.86
6bocB-4lg8A:
6.86
6bocC-4lg8A:
6.86
6bocD-4lg8A:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 8 LEU A 238
LEU A 257
HIS A 217
LEU A 216
 None
 0.91A 6cbzA-4lg8A:
undetectable		 6cbzA-4lg8A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		4 / 6 GLY A 368
THR A 367
SER A 325
SER A 324
 None
 1.08A 6jogA-4lg8A:
undetectable		 6jogA-4lg8A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens) 		5 / 12 ILE A 290
TRP A 291
PHE A 280
LEU A 314
ILE A 335
 None
 1.09A 7dfrA-4lg8A:
undetectable		 7dfrA-4lg8A:
18.38