SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lg9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		4 / 7 THR A 229
VAL A 286
GLY A 285
ASP A 246
 None
 0.69A 2a1mA-4lg9A:
undetectable		 2a1mA-4lg9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		4 / 8 VAL A 498
VAL A 489
LEU A 510
HIS A 467
 None
 1.00A 2ddwA-4lg9A:
undetectable		 2ddwA-4lg9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 VAL A 228
GLY A 247
TYR A 245
GLN A 303
HIS A 265
 None
None
None
UNX  A 604 ( 4.4A)
None
 1.37A 3bwyA-4lg9A:
undetectable		 3bwyA-4lg9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 ALA A 241
ALA A 176
PHE A 173
ILE A 269
ALA A 271
 None
 1.07A 3jb1A-4lg9A:
undetectable		 3jb1A-4lg9A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 GLY A 243
GLY A 247
ALA A 241
PHE A 270
LEU A 272
 None
 1.04A 3mteB-4lg9A:
undetectable		 3mteB-4lg9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 GLY A 243
GLY A 247
ALA A 241
PHE A 270
LEU A 272
 None
 0.91A 3p2kA-4lg9A:
undetectable		 3p2kA-4lg9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 GLY A 243
GLY A 247
ALA A 241
PHE A 270
LEU A 272
 None
 0.98A 3p2kC-4lg9A:
undetectable		 3p2kC-4lg9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		4 / 6 THR A 290
GLN A 302
ILE A 292
SER A 324
 None
 1.27A 3peoG-4lg9A:
undetectable		 3peoG-4lg9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 GLN A 208
HIS A 168
ASP A 190
SER A 186
ALA A 502
 None
 1.13A 3sueB-4lg9A:
undetectable		 3sueB-4lg9A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		3 / 3 ASP A 182
ARG A 513
LYS A 497
 UNX  A 616 ( 3.3A)
None
None
 1.07A 3wipG-4lg9A:
undetectable		 3wipG-4lg9A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 GLY A 460
ALA A 418
VAL A 466
HIS A 467
ILE A 468
 None
 1.13A 4rvdA-4lg9A:
undetectable		 4rvdA-4lg9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 GLY A 460
ALA A 418
VAL A 466
HIS A 467
ILE A 468
 None
 1.15A 4rvgA-4lg9A:
undetectable		 4rvgA-4lg9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		4 / 5 SER A 417
ALA A 416
HIS A 390
LEU A 373
 None
 1.45A 5dzkb-4lg9A:
undetectable
5dzkp-4lg9A:
undetectable		 5dzkb-4lg9A:
20.10
5dzkp-4lg9A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		4 / 5 SER A 417
ALA A 416
HIS A 390
LEU A 373
 None
 1.46A 5dzkc-4lg9A:
undetectable
5dzkq-4lg9A:
undetectable		 5dzkc-4lg9A:
20.10
5dzkq-4lg9A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		3 / 3 PRO A 179
LEU A 231
SER A 235
 None
 0.77A 5fsaB-4lg9A:
undetectable		 5fsaB-4lg9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 VAL A 352
ASP A 369
LEU A 415
ALA A 354
ARG A 425
 None
 1.32A 5hnzB-4lg9A:
undetectable		 5hnzB-4lg9A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 ASP A 246
HIS A 213
SER A 230
GLY A 263
LEU A 262
 None
 1.44A 5m50B-4lg9A:
undetectable		 5m50B-4lg9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		4 / 6 THR A 423
ARG A 425
ILE A 394
GLU A 393
 None
 1.15A 5uigA-4lg9A:
undetectable		 5uigA-4lg9A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		5 / 12 SER A 447
GLY A 485
SER A 479
CYH A 490
GLU A 488
 None
 1.47A 5wbvA-4lg9A:
undetectable		 5wbvA-4lg9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens) 		3 / 3 LYS A 335
ASN A 320
SER A 318
 UNX  A 605 ( 4.6A)
UNX  A 613 ( 4.5A)
UNX  A 605 ( 3.3A)
 1.22A 5yw0A-4lg9A:
undetectable		 5yw0A-4lg9A:
19.36