SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 5 SER A 206
SER A 209
PHE A  19
PHE A 264
 None
 1.26A 1oipA-4lgcA:
undetectable		 1oipA-4lgcA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 6 PRO A 114
MET A 115
ALA A 119
GLU A 123
 None
 1.38A 1qhyA-4lgcA:
undetectable		 1qhyA-4lgcA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 8 PHE A 237
ILE A 202
GLY A 212
TYR A 317
 None
 0.71A 1rtsA-4lgcA:
undetectable		 1rtsA-4lgcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 8 LEU A  36
GLN A  35
PHE A 103
LEU A  66
 None
 0.76A 1v54C-4lgcA:
undetectable
1v54J-4lgcA:
undetectable		 1v54C-4lgcA:
18.48
1v54J-4lgcA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 8 LEU A  36
GLN A  35
PHE A 103
LEU A  66
 None
 0.81A 1v54P-4lgcA:
undetectable
1v54W-4lgcA:
undetectable		 1v54P-4lgcA:
18.48
1v54W-4lgcA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		5 / 11 ILE A  99
ILE A 100
GLY A 235
LEU A  36
PHE A 103
 None
 1.15A 2azyA-4lgcA:
undetectable		 2azyA-4lgcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 8 LEU A  36
GLN A  35
PHE A 103
LEU A  66
 None
 0.75A 2dyrC-4lgcA:
undetectable
2dyrJ-4lgcA:
undetectable		 2dyrC-4lgcA:
18.48
2dyrJ-4lgcA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 8 LEU A  36
GLN A  35
PHE A 103
LEU A  66
 None
 0.78A 2dyrP-4lgcA:
undetectable
2dyrW-4lgcA:
undetectable		 2dyrP-4lgcA:
18.48
2dyrW-4lgcA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 7 LEU A  36
TRP A  63
ALA A  48
PHE A 103
 None
 0.96A 2wq5A-4lgcA:
undetectable		 2wq5A-4lgcA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		5 / 12 PHE A 264
GLN A 217
LEU A 275
LEU A 311
LEU A 219
 None
 1.43A 3adxA-4lgcA:
undetectable		 3adxA-4lgcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 8 LEU A  36
GLN A  35
PHE A 103
LEU A  66
 None
 0.84A 3ag4C-4lgcA:
undetectable
3ag4J-4lgcA:
undetectable		 3ag4C-4lgcA:
18.48
3ag4J-4lgcA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 7 LEU A  36
GLN A  35
PHE A 103
LEU A  66
 None
 0.82A 3asnC-4lgcA:
undetectable
3asnJ-4lgcA:
undetectable		 3asnC-4lgcA:
18.48
3asnJ-4lgcA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		3 / 3 ASN A  23
MET A 211
PHE A 237
 None
 1.15A 3g4lD-4lgcA:
undetectable		 3g4lD-4lgcA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		3 / 3 HIS A 294
GLY A 333
ILE A 316
 None
 0.60A 4k50A-4lgcA:
undetectable		 4k50A-4lgcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		3 / 3 HIS A 294
GLY A 333
ILE A 316
 None
 0.61A 4k50I-4lgcA:
undetectable		 4k50I-4lgcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 7 PHE A 237
ILE A 202
GLY A 212
TYR A 317
 None
 0.76A 5h3aA-4lgcA:
undetectable		 5h3aA-4lgcA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 7 PHE A 237
ILE A 202
GLY A 212
TYR A 317
 None
 0.67A 5h3aB-4lgcA:
undetectable		 5h3aB-4lgcA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 7 PHE A 237
ILE A 202
GLY A 212
TYR A 317
 None
 0.80A 5x5qC-4lgcA:
undetectable		 5x5qC-4lgcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 8 PHE A 237
ILE A 202
GLY A 212
TYR A 317
 None
 0.78A 5x5qD-4lgcA:
undetectable		 5x5qD-4lgcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 6 PHE A 237
ILE A 202
GLY A 212
TYR A 317
 None
 0.79A 5x5qE-4lgcA:
undetectable		 5x5qE-4lgcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 8 PHE A 237
ILE A 202
GLY A 212
TYR A 317
 None
 0.76A 5x5qF-4lgcA:
undetectable		 5x5qF-4lgcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4lgc BILE ACID-COENZYME A
LIGASE
([Clostridium]
scindens) 		4 / 7 LEU A  36
GLN A  35
PHE A 103
LEU A  66
 None
 0.92A 5zcoC-4lgcA:
undetectable
5zcoJ-4lgcA:
undetectable		 5zcoC-4lgcA:
18.48
5zcoJ-4lgcA:
7.86