SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lgm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		4 / 8 LEU A 207
ASP A 257
LEU A 261
LEU A 256
 None
 1.08A 1e7cA-4lgmA:
undetectable		 1e7cA-4lgmA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A 273
PRO A 143
GLY A 144
CYH A 145
 None
None
CL  A 401 ( 4.4A)
None
 0.75A 1h4oB-4lgmA:
undetectable		 1h4oB-4lgmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A 273
PRO A 143
GLY A 144
CYH A 145
 None
None
CL  A 401 ( 4.4A)
None
 0.72A 1h4oG-4lgmA:
undetectable		 1h4oG-4lgmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A 273
PRO A 143
GLY A 144
CYH A 145
 None
None
CL  A 401 ( 4.4A)
None
 0.75A 1oc3A-4lgmA:
undetectable		 1oc3A-4lgmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		4 / 7 LEU A 115
ILE A 119
ALA A 151
ILE A 204
 None
 0.91A 1oniB-4lgmA:
undetectable
1oniC-4lgmA:
undetectable		 1oniB-4lgmA:
19.59
1oniC-4lgmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		4 / 7 PHE A 203
ALA A 249
ILE A 150
ILE A 268
 None
 0.91A 1oniD-4lgmA:
undetectable
1oniF-4lgmA:
undetectable		 1oniD-4lgmA:
19.59
1oniF-4lgmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A 139
ALA A 155
ALA A 151
VAL A 270
LEU A 108
 None
 1.16A 1rlbF-4lgmA:
undetectable		 1rlbF-4lgmA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 233
PHE A 186
ASN A 226
 None
 0.73A 1sg9B-4lgmA:
2.6		 1sg9B-4lgmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A 201
ILE A 137
ALA A 118
VAL A 154
 None
 0.73A 4jltA-4lgmA:
undetectable		 4jltA-4lgmA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 112
ASP A 110
ILE A 119
 None
 0.85A 5kc4E-4lgmA:
undetectable		 5kc4E-4lgmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lgm VPS4 AAA ATPASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A 115
ILE A 137
GLY A 248
ILE A 201
LEU A 229
LEU A 210
 None
 1.28A 5ycnA-4lgmA:
undetectable		 5ycnA-4lgmA:
23.49